Results 11 to 20 of about 514,665 (154)
Zhongshan Daxue xuebao. Yixue kexue ban, 2012 摘要：【目的】 局部免疫法治疗重型斑秃在国外的使用历史已逾30年，但国内尚未广泛开展，本研究旨在分析该法治疗中国重型斑秃患者的疗效及初步探讨作用机制。【方法】 对63例斑秃患者进行二苯环丙烯酮局部免疫治疗。治疗前进行皮肤镜、实验室、病理检查，治疗过程中对血常规、总IgE进行监测并复查部分患者头皮病理。同时检测21名患者治疗前后血清细胞因子浓度，并征集正常对照13人，年龄性别与斑秃组相匹配。【结果】 本组患者总有效率为61.0%，疗效仅与脱发面积成负相关，即面积越小，疗效越好，而与其它临床资料无相关关系 ...
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Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】探讨强化免疫抑制治疗儿童再生障碍性贫血的疗效及毒副作用的防治。【方法】总结我科1996—2003年儿童再障32例,均采用强化免疫抑制治疗(IIST),根据免疫抑制药物的不同组合分为2组:4种药物联合组和2～3种药物联合组。【结果】总有效率为71.88%,4种药物联合组、2～3种药物联合组有效率分别为72.2%及71.33%,差别无显著性。治疗过程中,致命的合并症为败血症,尤其潜伏病毒激活及深部真菌感染。随访中没有病例发展为阵发性睡眠性血红蛋白尿(PNH),骨髓异常增生综合征(MDS ...
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重组干扰素治疗慢性丙型肝炎的临床及肝组织学疗效评价 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 1994 报告８４例慢性丙型肝炎（ＣＨＣ）患者，通过临床、血清学、肝组织学、分子生物学和免疫组织化学等方法，观察应用重组α－干扰素加传统护肝治疗的效果，疗程２４周，并与单用传统护肝治疗的对照组治疗前后各项指标变化比较。疗程结束时结果显示：治疗组６４例中，血清ＡＬＴ复常率为７０．３％，ＨＣＶ－ＲＮＡ阴转率为６７．２％，肝组织学好转率为６５．６％，肝组织内ＨＣＶ－ＲＮＡ阴转率为５１．５％，肝组织内ＨＣＶ－Ａｇ抗原的免疫组化检出率从治疗前的１５．６％减至治疗后的６．３％，分别显著高于对照组（Ｐ＜０．０５ ...
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Zhongshan Daxue xuebao. Yixue kexue ban, 1990 用戊二醛使野苋菜花粉变应原聚合,再用凝胶层析法将大分子聚合变应原析出。免疫学实验表明该聚合变应原免疫原性不变而变应原性减低。28例支气管哮喘的临床对照研究表明,聚合变应原免疫治疗起效快,疗效好,可能减低气道的非特异反应性,未发现全身副反应。
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Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Bone restoration is often hindered by the spatiotemporal dysregulation of immune and regenerative signals. Conventional bio‐inert implants, providing only passive support, fail to modulate this microenvironment, leading to infections and poor healing.
Zhizhong Sun +8 more
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Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang +6 more
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, 2006 激光免疫疗法是一种新型肿瘤治疗方法,治疗过程中包括三个基本要素：激光、光敏剂(光吸收剂)和免疫佐剂。该疗法可通过光化学作用在一定范围内破坏肿瘤组织；免疫佐剂还能诱导机体产生免疫反应,杀灭原发肿瘤和转移瘤,并产生肿瘤特异性免疫力,表现出很好的远期疗效。目前应用于激光免疫治疗的有630、652、671、690和810nm波长激光,光敏剂(光吸收剂)有吲哚菁绿、血卟啉衍生物及酞氰类化合物等,免疫佐剂有糖基化聚氨基葡糖、OK-432、MCWE ...
罗芳洪, 黄萍, 曾超英
core
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma +6 more
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Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment.
Xuan Li +7 more
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Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is often limited, whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy. To address this challenge, this study developed a reactive oxygen species (ROS)‐responsive and mitochondria‐targeted nanomicelle (POM@CTT ...
Qingqing Dou +6 more
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