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Biomimetic Metallopeptidases for Biomedical Applications: From Modular Design to Disease Treatment
Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT Biomimetic metallopeptidases, as an emerging class of artificial enzyme systems, have demonstrated tremendous application potential in the biomedical field in recent years. Their core design principle is to rationally control amino acid composition and three‐dimensional conformation so that programmable peptide sequences can efficiently ...
Ke Ma, Ke‐Zheng Chen, Sheng‐Lin Qiao
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2016 免疫抑制是肿瘤患者治疗疗效差、预后不理想的重要原因之一。肿瘤免疫抑制不仅与恶性肿瘤的发生、发展有关,而且与肿瘤免疫治疗疗效不佳及治疗后复发密切相关。因而改善或逆转免疫抑制对成功治疗肿瘤具有十分重要的意义。多种免疫细胞成分,如髓源抑制性细胞（myeloid-derived suppressor cells,MDSCs）、肿瘤相关巨噬细胞（tumor-associated macrophage,TAM）、调节性T细胞(regulatory T cells,
朱晓青, 苏龙, 高素君
doaj
Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng +8 more
wiley +1 more source
, 2021 内淋巴注射药物的治疗效果基于三种作用机制:由于抗生素对淋巴管的趋向性,在生物体液、淋巴结和炎症焦点中产生最大长期治疗浓度的药物。系统,它们与淋巴结淋巴细胞接触的能力;在微血管和间质中生物体液循环水平上使微循环系统正常化;免疫调节作用,表现为免疫调节剂与淋巴结免疫活性细胞的直接接触。一种有希望的治疗效果是免疫调节剂的内淋巴给药方法,因为后者对淋巴结的 T 和 B 淋巴细胞的某些亚群有直接影响。临床数据分析表明 ...
Akhmedov M.D +4 more
core +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 4, Page 455-460, April 2026.ABSTRACT Objective To estimate the residual risk of maternal–fetal transmission after primary cytomegalovirus (CMV) infection in the periconceptional period or the first trimester in women treated with valacyclovir, and to assess whether the presence of glycoprotein B2 (gB2)‐specific immunoglobulin (Ig)‐G antibodies on immunoblot analysis refines fetal
K. O. Kagan +6 more
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中西医结合护理, 2022 Objective To observe the effect of Tonifying deficiency and Zhengqi porridge on immune function reconstruction of HIV/AIDS patients with Qi deficiency.
WEI Yan (魏艳) +5 more
doaj +1 more source
Thoracic Cancer, Volume 17, Issue 8, April 2026.Short videos on Chinese social media have become a primary source of lung cancer information for patients and caregivers. This cross‐sectional study analyzed 300 lung cancer treatment videos from TikTok, Bilibili, and Kwai (2020–2025). Overall quality was alarmingly low: only 6% of videos met high‐quality criteria (GQS ≥ 4), and 5% met DISCERN ≥ 4 ...
Zengrui Wang +5 more
wiley +1 more source
Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2020 目的探讨自身免疫病病人外周血NK(CD3-CD16+CD56+)细胞在自身免疫病发病机制中的作用。方法用流式细胞术检测29例自身免疫病病人和18例健康对照者外周血NK(CD3-CD16+CD56+)细胞数,同时检测NK细胞的胞膜活化性受体NKG2D(CD314)和抑制性受体NKG2A(CD159)以及穿孔素、颗粒酶-β的表达。结果自身免疫病病人外周血NK细胞数与健康对照组无明显差别。自身免疫病病人NK细胞膜活化性受体NKG2D和颗粒酶-β的表达在治疗前和治疗后均低于正常对照组 ...
陈琳 +7 more
doaj
Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source