Results 21 to 30 of about 14,135 (164)
Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
Nursing of a patient with Sintilimab-induced autoimmune myocarditis (1例信迪利单抗治疗后出现免疫性心肌炎患者的护理)
中西医结合护理, 2023 This paper summarized the nursing management for a patient with autoimmune myocarditis after 2 courses of Sintilimab. The patient received hormonotherapy, immunoregulation and other drug treatment.
HUANG Wenyi (黄雯薏) +4 more
doaj +1 more source
Involvement of Abnormal MicroRNA Expression in the Mechanism of Drug Resistance with Acute Myeloid Leukemia [PDF]
, 2016 目的：分析miRNA-98的表达异常在急性髓系白血病化疗耐药机制的作用，通过靶向过表达miRNA-98的表达水平探讨以miRNA-98为靶点增加化疗药物敏感性的可能性并分析其可能作用的机制。评价异常表达的血清miRNA-155是否可作为急性髓系白血病的预后标志。 方法：离体实验中，采用qRT-PCR方法检测K562和其耐药株K562/A02中miR-98、E2F1基因表达情况。通过瞬时转染miR-98mimic处理耐药细胞K562/A0248h后，通过qRT-PCR法检测miR-98表达情况；通过qRT-
黄英丹
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Research of Glycoprobe Based Cancer Immunotherapy [PDF]
, 2017 随着癌症发病率和死亡率的不断升高，有效的治疗方法具有重要的临床价值。传统治疗方法如放疗和化疗，虽在治疗初期有一定效果，但治疗后期肿瘤容易复发。机体免疫系统本身具有抗肿瘤潜力，但肿瘤细胞会通过改变表面结构逃避免疫识别，为了使免疫系统识别、杀灭自身肿瘤，人们发展了肿瘤免疫疗法。常用策略是通过基因工程的方法改造免疫细胞，使其识别肿瘤。但该方法技术难度大，成本高周期长，限制了其广泛应用。在此我们拟发展一种改变肿瘤细胞结构，引发免疫识别的新型免疫疗法。由于肿瘤细胞表面唾液酸的结构与丰度直接影响了免疫识别过程 ...
林碧娟
core
Progress in targeting tumor-associated macrophages in cancer immunotherapy [PDF]
As the member of immune cells, macrophages are necessary to fight against pathogenic invasion and activate T cell-mediated adaptive immune responses.
ZHANG Siyu, ZHOU Qiong
core +1 more source
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2016 免疫抑制是肿瘤患者治疗疗效差、预后不理想的重要原因之一。肿瘤免疫抑制不仅与恶性肿瘤的发生、发展有关,而且与肿瘤免疫治疗疗效不佳及治疗后复发密切相关。因而改善或逆转免疫抑制对成功治疗肿瘤具有十分重要的意义。多种免疫细胞成分,如髓源抑制性细胞（myeloid-derived suppressor cells,MDSCs）、肿瘤相关巨噬细胞（tumor-associated macrophage,TAM）、调节性T细胞(regulatory T cells,
朱晓青, 苏龙, 高素君
doaj
Application and prospect of targeted therapy and immunotherapy in radioiodine-refractory differentiated thyroid cancer [PDF]
Thyroid cancer (TC) is a common malignant tumor of the endocrine system, with differentiated TC (DTC) accounting for more than 90%. Most patients usually have a good overall prognosis after receiving radioactive iodine (RAI) treatment, however some ...
LIN Qiuyu, WANG Yuxin, LIN Chenghe
core +1 more source
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source