[Research Progress on Predictive Biomarkers of Immunotherapy Efficacy in Non-small Cell Lung Cancer]. [PDF]
Zhongguo Fei Ai Za Zhi肺癌是世界上最常见的恶性肿瘤之一，其中非小细胞肺癌（non-small cell lung cancer, NSCLC）占大多数。免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）的出现极大地改变了NSCLC的治疗策略，并改善了患者预后，然而现实中只有少部分患者能够获得长期受益。因此，确定可靠的预测生物标志物对选择治疗方式至关重要。随着近年来分子生物学、基因组测序技术的发展以及对肿瘤及其宿主免疫微环境的认识不断深入，生物标志物的研究层出不穷 ...
Sun T, Chen Z, Wei K, Tang H.
europepmc +2 more sources
[Analysis of the Correlation between Immune Cell Subsets in Bronchoalveolar Lavage Fluid and the Efficacy of First-line Use of Immunotherapy in Advanced Non-small Cell Lung Cancer: A Case-control Study]. [PDF]
Zhongguo Fei Ai Za Zhi背景与目的 免疫治疗已成为晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）患者的标准治疗，但对于接受免疫治疗的晚期NSCLC患者仍缺乏特异性的疗效预测生物标志物，本研究通过探索支气管肺泡灌洗液（bronchoalveolar lavage fluid, BALF）中淋巴细胞亚群情况，并结合NSCLC患者的临床和实验室检查指标，探索潜在的免疫治疗相关性生物标志物。 方法 ...
Zhang K +5 more
europepmc +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban, 1990 用戊二醛使野苋菜花粉变应原聚合,再用凝胶层析法将大分子聚合变应原析出。免疫学实验表明该聚合变应原免疫原性不变而变应原性减低。28例支气管哮喘的临床对照研究表明,聚合变应原免疫治疗起效快,疗效好,可能减低气道的非特异反应性,未发现全身副反应。
doaj +2 more sources
Clinical analysis of anti-N-methyl-D-aspartate receptor encephalitis patients with cerebellar ataxia [PDF]
, 2021 摘要： 目的:分析总结合并小脑共济失调的抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎患者的临床特点。方法:回顾分析北京协和医院2011—2019年诊治的抗NMDAR脑炎患者中合并小脑共济失调患者的临床表现、实验室检查结果、治疗与预后。结果:347例抗NMDAR脑炎患者中共有15例（4.3%）合并小脑共济失调，其中1例患者合并卵巢畸胎瘤，男性7例，女性8例，中位年龄28岁，从脑炎发病到出现小脑症状平均病程30.8 d，极期改良Rankin量表（mRS）评分平均3.73分 ...
任海涛 +7 more
core +1 more source
Chinese expert consensus on immunotherapy for gynecological malignant tumors (2023 edition) [PDF]
, 2023 Immunotherapy, as the fourth largest anti-tumor treatment method, has made breakthrough progress in the field of cancer treatment. Checkpoint inhibitors have been widely used in the treatment of various malignant tumors, and a lot of clinical evidence ...
Society of Onco-Endocrinology of Chinese Anti-Cancer Association
core +1 more source
珠三角地区变应性鼻炎和/或支气管哮喘患者皮下特异性免疫治疗依从性的真实世界研究 [PDF]
, 2022 目的了解珠三角地区变应性鼻炎（AR）和/或支气管哮喘患者（BA）中止皮下变应原免疫治疗（SCIT）的原因，为提高患者SCIT的依从性提供参考依据。方法本研究是一项回顾性、多中心、大样本的真实世界研究，收集和分析2015年1月到2020年12月在珠三角地区6家三甲医院接受SCIT的AR和/或BA患者的临床资料，并对中止治疗患者的进行电话随访。结果纳入1 244例接受SCIT的患者，中止治疗427例（脱落率为34.3%）；儿童、已婚、过敏家族史阳性、总IgE （tIgE）>200 U ...
唐隽 +7 more
core +1 more source
Advances in immunotherapy of advanced non-small cell lung cancer with EGFR mutation [PDF]
, 2023 The incidence of epidermal growth factor receptor (EGFR) mutation in non-small cell lung cancer (NSCLC) in Asians is significantly higher than that in Westerners. For the past few years, immune checkpoint inhibitors (ICIs) that target the programmed cell
HUANG Huayan +4 more
core +1 more source
Evaluation of medication treatment for Alzheimer's disease on clinical evidence [PDF]
, 2014 Objective To formulate the best treatment plan for Alzheimer's disease patients by evaluating the therapeutic efficacy and side effect of various evidence-based programs.
Ling LIU +3 more
core +2 more sources
The Anatomical Record, Volume 306, Issue 12, Page 3214-3228, December 2023., 2023 Abstract The effectiveness and safety of electroacupuncture (EA) for constipation have been confirmed by numerous clinical studies and experiments, and there are also studies on the efficacy of EA for Parkinson's disease (PD) motor symptoms. However, there are few researches on EA for PD constipation.
Li‐Zhe‐Xiong Song +8 more
wiley +1 more source
Important clinical research progress in lung cancer in 2022 [PDF]
, 2023 Lung cancer remains the malignant tumor with the highest morbidity and mortality in China, among which non-small cell lung cancer (NSCLC) accounts for more than 80%.
SU Chunxia, ZHOU Caicun
core +1 more source