Nursing of a patient with Sintilimab-induced autoimmune myocarditis (1例信迪利单抗治疗后出现免疫性心肌炎患者的护理)
中西医结合护理, 2023 This paper summarized the nursing management for a patient with autoimmune myocarditis after 2 courses of Sintilimab. The patient received hormonotherapy, immunoregulation and other drug treatment.
HUANG Wenyi (黄雯薏) +4 more
doaj +1 more source
Preparation of monoclonal antibodies against mouse alpha-fetoprotein and preliminary study on their application [PDF]
, 2016 原发性肝癌是我国高发的恶性肿瘤之一，每年新发和死亡患者均占全球总数的一半以上。根据全国肿瘤登记中心最新公布的2015年《肿瘤登记年报》数据，我国肝癌新增病例为46.61万，占所有恶性肿瘤的第4位（10.86%），而死亡病例为42.21万，占所有癌症死亡的第3位（15.00%），仅次于肺癌和胃癌。尽管近年来肝癌的诊断和治疗有了一定的进展，其预后仍然不理想，五年生存率极低。究其原因，大部分肝癌患者往往在疾病的晚期才被诊断出来，有些甚至发生了远端转移，因而错过了最佳治疗时机；此外 ...
潘海娇
core
Recent Advances and Hot Spots of Neoadjuvant Immunotherapy Combined with Chemotherapy for Esophageal Carcinoma [PDF]
Surgery-based multidisciplinary comprehensive treatment is the preferred treatment strategy for local advanced esophageal cancer. Neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy have been recommended by the Chinese Society of Clinical Oncology
Chunyue GAI +8 more
core +1 more source
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
Research of Glycoprobe Based Cancer Immunotherapy [PDF]
, 2017 随着癌症发病率和死亡率的不断升高，有效的治疗方法具有重要的临床价值。传统治疗方法如放疗和化疗，虽在治疗初期有一定效果，但治疗后期肿瘤容易复发。机体免疫系统本身具有抗肿瘤潜力，但肿瘤细胞会通过改变表面结构逃避免疫识别，为了使免疫系统识别、杀灭自身肿瘤，人们发展了肿瘤免疫疗法。常用策略是通过基因工程的方法改造免疫细胞，使其识别肿瘤。但该方法技术难度大，成本高周期长，限制了其广泛应用。在此我们拟发展一种改变肿瘤细胞结构，引发免疫识别的新型免疫疗法。由于肿瘤细胞表面唾液酸的结构与丰度直接影响了免疫识别过程 ...
林碧娟
core
Advances in Research on Lactate Metabolism Disorders and Their Effect on Immunotherapy in Lung Adenocarcinoma [PDF]
Recent studies have identified that metabolic reprogramming in lung adenocarcinoma cells, particularly lactate metabolism disorders, plays a crucial role in tumor development and immune therapy response.
Cixiang CHEN +6 more
core +1 more source
New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu +8 more
wiley +1 more source
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2016 免疫抑制是肿瘤患者治疗疗效差、预后不理想的重要原因之一。肿瘤免疫抑制不仅与恶性肿瘤的发生、发展有关,而且与肿瘤免疫治疗疗效不佳及治疗后复发密切相关。因而改善或逆转免疫抑制对成功治疗肿瘤具有十分重要的意义。多种免疫细胞成分,如髓源抑制性细胞（myeloid-derived suppressor cells,MDSCs）、肿瘤相关巨噬细胞（tumor-associated macrophage,TAM）、调节性T细胞(regulatory T cells,
朱晓青, 苏龙, 高素君
doaj
Involvement of Abnormal MicroRNA Expression in the Mechanism of Drug Resistance with Acute Myeloid Leukemia [PDF]
, 2016 目的：分析miRNA-98的表达异常在急性髓系白血病化疗耐药机制的作用，通过靶向过表达miRNA-98的表达水平探讨以miRNA-98为靶点增加化疗药物敏感性的可能性并分析其可能作用的机制。评价异常表达的血清miRNA-155是否可作为急性髓系白血病的预后标志。 方法：离体实验中，采用qRT-PCR方法检测K562和其耐药株K562/A02中miR-98、E2F1基因表达情况。通过瞬时转染miR-98mimic处理耐药细胞K562/A0248h后，通过qRT-PCR法检测miR-98表达情况；通过qRT-
黄英丹
core