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Veterinary Dermatology, Volume 35, Issue 4, Page 375-385, August 2024.Background – Perianal fistulas are painful ulcers or sinus tracts that disproportionately affect German shepherd dogs and are proposed as a spontaneous animal model of fistulising Crohn's disease. Objectives – To characterise the rectal and cutaneous microbiota in German shepherd dogs with perianal fistulas and to investigate longitudinal shifts with ...
Christine L. Cain +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2014 化疗是卵巢癌综合治疗的一个重要组成部分,是晚期和复发性卵巢癌的主要治疗手段,在控制腹水和预防复发的同时也会对机体产生一些不良反应,如骨髓及免疫功能抑制等,影响了患者治疗的依从性。本文通过观察43例卵巢上皮性癌患者首次化疗期间机体免疫功能的变化 ...
杨均
doaj
Treatment Strategy and Research Progress of Immune Microenvironment for Liver Metastasis of Non-small Cell Lung Cancer [PDF]
Liver is the common site for metastasis and spread of non-small cell lung cancer (NSCLC). Lung cancer patients with liver metastasis have poor prognosis, which may be related to liver-specific microenvironment composition.
SUN Jiaqi, WANG Yudong
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Pharmacology of drugs used in autoimmune dermatopathies in cats and dogs: A narrative review
Veterinary Dermatology, Volume 35, Issue 4, Page 453-476, August 2024.Immunosuppressive drugs are the mainstay of treatment for many feline and canine autoimmune skin diseases, either as monotherapy or in combination with other drugs. Treatment with these drugs is often lifelong and may have long‐term consequences on the affected animal's overall quality of life.
Heng L. Tham, Jennifer L. Davis
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2017 目的研究异体CIK联合血浆置换临床治疗肝癌的效应和机制。方法分离健康人外周血单个核细胞（PBMC）,加入细胞因子诱导成CIK细胞,体外培养扩增。病例均给予内科综合支持治疗情况下,随机分为异体CIK细胞治疗组和异体CIK+血浆置换治疗组。应用ELISA法比较二组治疗前后血浆中IFN-γ、IL-4、IL-10、TGF-β、VEGF的浓度变化;流式细胞术检测二组治疗前后患者外周血中CD3+和CD4+细胞比例、CD4+/CD8+比值、CD8+细胞比例;比较二组患者的生存质量、无进展生存期（PFS）、总生存期 ...
侯俊杰 +7 more
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Update on the role of cytokines and chemokines in canine atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 1, Page 25-39, February 2024.Background – Cytokines and chemokines play central roles in the pathogenesis of canine atopic dermatitis (cAD). Numerous studies have been published and provide new insights into their roles in cAD. Objectives – To summarise the research updates on the role of cytokines and chemokines in the pathogenesis of cAD since the last review by the ...
Chie Tamamoto‐Mochizuki +6 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 中枢神经自身免疫病是自身免疫异常导致神经系统损害的疾病。这类疾病发病机制不明，临床表现多样，治疗手段单一，最终结局各异，目前诊治面临巨大挑战。随着大数据技术、基因、蛋白组学及影像学新技术的发展，对特定疾病寻找个体化生物标记，寻找治疗新靶点，最终实现精确诊断和个体化治疗逐渐成为可能。本文将结合课题组已开展的工作，探讨中枢神经自身免疫病的精确诊断和治疗。
邱伟
doaj
浙江大学学报. 医学版由于缺乏有效的治疗手段，复发转移仍然是乳腺癌患者死亡的主要原因。在转移发生之前，远处器官内已经形成了适合乳腺癌细胞生长的微环境——转移前生态位（PMN）。髓源性抑制细胞（MDSC）是一类具有免疫抑制作用的异质性未成熟髓系细胞群，可在乳腺癌患者体内大量扩增，参与PMN的形成。MDSC不仅支持乳腺癌细胞免疫逃逸，而且还可通过重塑肺血管内皮细胞外基质、招募癌症干细胞来促进乳腺癌转移的发生。此外，MDSC还能通过削弱免疫疗法的抗肿瘤效率来降低药物的治疗效果。因此 ...
杜 楠楠 +4 more
doaj +1 more source
Progress in the development of mRNA vaccine and its delivery systems for anti-tumor immunotherapy [PDF]
Due to the drawbacks of low specificity and high risk of side effects of traditional anti-tumor treatments in clinical practice, novel anti-tumor immunotherapy has received attention and has been gradually applied.
XIN Meiyi, LIN Yuhong, ZHAO Kai
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, 2018 近年来,随着肝细胞癌基础研究不断深入,分子靶向药物及免疫治疗药物的临床开发及应用为肝细胞癌的治疗带来了新的突破。肝细胞癌的靶向治疗药物具有较高的特异性,能够选择性地杀伤肿瘤细胞,尽可能减少对正常组织的损伤。目前,这些靶向治疗药物主要分为小分子靶向药物、肝细胞癌抗原特异性靶向药物和免疫检验点靶向药物3类 ...
邱盛萍, 黄承浩
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