Results 11 to 20 of about 26,143 (169)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

Rare Metals, EarlyView.
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan, Shengjie Xue, Junyi Yin, Shaolei Wang, Yunlei Zhou, Jieyue Liao   +5 more
wiley   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Colorimetric and Photothermal Hollow Nanocomposite Based on Silver‐Seeded Prussian Blue Analog for Dopamine Monitoring and Photothermal Sterilization

Rare Metals, EarlyView.
ABSTRACT Multi‐element Prussian blue analog (PBA) nanocomposites have attracted wide attention for their superior characteristics to single‐functional nanomaterials in extensive applications of diagnosis and therapy. In this study, a novel hollow nanocomposite was designed and fabricated by embedding S2− and Ag nanoparticles into a NiCuMnFe (PBA).
Tao Ji, Ze Xu, Ying Wang, Xingchen Lu, Yuqian Zhu, Qingli Huang, Quanshuang Li, Shibao Li   +7 more
wiley   +1 more source

An Ultrasmall Strontium‐Loaded Polydopamine Nanoformulation for Near‐Infrared‐Enhanced Periodontitis Therapy via Photodynamic Gas‐Promoted Antibacterial and Bone Repair

Rare Metals, EarlyView.
ABSTRACT Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria, resulting in the progressive inflammation and destruction of the tissues surrounding teeth. To achieve reprogramming of the infectious microenvironment for periodontitis therapy, a nanoformulation was proposed by loading polydopamine (PDA) with ...
Hao Liang, Yu Liang, Rubiao Qiu, Kunpeng Duan, Jiaxiao Li, Yan Liu, Xiaowen Li, Li Wang, Lingling Liang, Mingyang Jiang, Chenxi Wang, Guojiang Chen, Ming Gao, Xiaojie Li, Tao Qin   +14 more
wiley   +1 more source

High‐Temperature Stable Narrowband Near‐Infrared Phosphor‐Converted Light‐Emitting Diode Based on Melt‐Grown CsPbCl3: Yb3+ Crystal

Rare Metals, EarlyView.
ABSTRACT Narrowband near‐infrared (NIR) phosphor‐converted light‐emitting diodes (pc‐LEDs) featuring low full‐width at half maximum (FWHM) and high conversion efficiency are crucial for chemical content evaluation, light therapy, and bioimaging.
Chunshen Li, Yuexin Zhu, Wendong Nie, Haomiao Zhu, Peng Zhang   +4 more
wiley   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, EarlyView.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

化肝汤1号对酒精性肝纤维化TGFβ1和HA水平的影响

Zhongguo shiyan zhenduanxue, 2011
目的观察化肝汤1号对酒精性肝纤维化转化生长因子β1和透明质酸水平的影响。方法对临床确诊的60例肝纤维化患者,随机单盲分为治疗组和对照组,每组30人,治疗组用自制方剂化肝汤1号治疗,对照组用凯西莱治疗,疗程12周。结果 TGFβ1变化,治疗组治疗前为164.83±6.50,治疗后为119.70±5.14,对照组治疗前为162.07±4.55,治疗后为132.07±4.44,治疗组与对照组治疗前后比较 ...
郝彦开, 杨玉巧, 贾军峰, 郭皓, 左馨卉   +4 more
doaj  

Association between Polymorphisms of ERCC1 and Response in Patients with Advanced Non-small Cell Lung Cancer Receiving Cisplatin-based Chemotherapy [PDF]

, 2010
Background and objective Results of studies on genetic polymorphisms of ERCC1 gene in DNA repair pathway which may affect response to platinum-based chemotherapy and survival in patients with non-small cell lung cancer are conflicting.
Hui ZHANG, Jinghui WANG, Quan ZHANG, Qunhui WANG, Shucai ZHAN, Xinjie YANG, Yanfei GU   +6 more
core  

Hospice and Palliative Care‐Related Policy in the United States and Germany in the Context of Recent Governmental Changes

World Medical &Health Policy, EarlyView.
ABSTRACT Population aging is a problem that countries around the globe are facing; it comes with complex healthcare needs. Different countries take different approaches to solving these issues. In the United States, proposed legislation related to hospice and palliative care emerged from a history of hospice fraud and specialty physician shortages.
Edith‐Marie Green
wiley   +1 more source