Results 81 to 90 of about 1,168,224 (184)

中国汉族人群CAV1/CAV2基因多态性与2型糖尿病的关系

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2018
: 【目的】研究中国汉族人群微囊蛋白-1/-2(caveolin-1/-2)的编码基因CAV1/CAV2单核苷酸多态性 (SNP)与2型糖尿病(T2DM)的相关性。【方法】应用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)方 法对559例汉族人(T2DM组272例、对照组287例)CAV1/CAV2基因座的14个SNPs位点进行基因分型;同时进行 人体测量学及代谢指标的检测,并用稳态模型评估胰岛素抵抗(HOMA-IR)和胰岛β细胞功能(HOMA-β)。 【结果 ...
邹丽媛   +3 more
doaj  

The Evolution of Metal Halide Perovskite Transistors

open access: yesRare Metals, Volume 45, Issue 9, September 2026.
ABSTRACT Metal halide perovskites (MHPs) offer a revolutionary pathway for next‐generation field‐effect transistors (FETs) because of their exceptional carrier mobilities and cost‐effective processability. However, their transition to practical electronics is significantly challenged by intrinsic instability and imbalanced charge transport. This review
Jiangnan Xia   +8 more
wiley   +1 more source

一种紫贻贝G型溶菌酶基因及其重组蛋白和应用

open access: yes, 2011
本发明涉及溶菌酶,具体的说是一种紫贻贝G型溶菌酶基因及其重组蛋白和应用。G型溶菌酶基因如序列表SEQ?ID?NO.1中的碱基序列所示。通过PCR技术,扩增编码G型溶菌酶成熟肽的基因片断并将其克隆到pET21(a)表达载体中,在大肠杆菌BL21(DE3)plysS中实现了原核体外重组表达。重组产物经镍柱亲和层析纯化和透析复性后,对多种革兰氏阳性和阴性病原菌都有一定的抑制作用,其中恶臭假单胞菌的作用最为显著,最小抑菌浓度为2.39-4.79μmol/L。本发明可为进一步研究经济贝类免疫防御机制提供基础 ...
赵建民, 王清, 张林宝, 吴惠丰
core  

Closing the Vicious Cycle: A Multimodal Hydrogel Targeting Hyperglycemia, Oxidative Stress, and Infection in Diabetic Wounds

open access: yesRare Metals, Volume 45, Issue 9, September 2026.
ABSTRACT Diabetic chronic wounds, characterized by a unique pathological microenvironment including persistent hyperglycemia, excessive reactive oxygen species (ROS), bacterial infection, and sustained inflammation, exhibit notoriously impaired and delayed healing processes. This study developed a multifunctional hydrogel therapeutic system (GOx@Zn‐MPN
Baowei Zhai   +11 more
wiley   +1 more source

表达Xa21基因的转基因水稻研究

open access: yes, 2001
对Xa2 1在转基因水稻新汕B后代R1、R2 群体的遗传方式及稳定性进行初步分析 .特异PCR分析从分子水平表明Xa2 1基因已稳定遗传至R1代 ,自交R1代的抗感带型分离比为 3:1,揭示出Xa2 1基因在转基因水稻中按孟德尔方式遗传 .Hyg培养基发芽和田间接菌鉴定显示 ,Xa2 1转基因水稻对Hyg和白叶枯病的抗性多数在后代中出现3:1的分离 ,对白叶枯病的抗病性呈连续分布 ,能传递至较高世代 ,并且能在R2 代获得纯合株系 .图 3表 3参 ...
王芋华,刘勇,王世全,罗科,李平   +1 more
core  

PCR-SSP对潜在输血需要住院患者ABO基因分型的检测效果与意义

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2013
【目的】 调查潜在输血需要住院患者的ABO血型基因,分析ABO表型相同输血中ABO基因型的错配输血几率。【方法】 对502例潜在输血需要的住院患者,采用血清学方法和聚合酶链反应-序列特异性扩增技术(PCR-SSP)检测ABO血型的表型及基因型。比较两种方法学对ABO血型表型的一致率;统计各ABO等位基因及各ABO基因型的频率;并分析潜在输血需要的住院患者在接受ABO血型表型相同的输血时,ABO基因错配输血几率。 【结果】 血清学与PCR ...
doaj  

Anchoring Polyoxometalate (PMo11Fe) on ZnO Nanosheet for Construction of a Novel S‐Scheme Heterojunction Toward Efficient Photodegradation of Levofloxacin Antibiotics

open access: yesRare Metals, Volume 45, Issue 9, September 2026.
ABSTRACT Currently, the photocatalytic performance of ZnO has been severely limited by its weak light response ability and sluggish charge carrier dynamics, which considerably hinder its extensive application in photocatalytic fields. Herein, through anchoring the synthesized K6PMo11FeO40·nH2O (PMo11Fe) onto ZnO nanosheets, a novel S‐scheme ...
Xinjia Zhang   +8 more
wiley   +1 more source

我國首座轉基因植物隔離試驗核心設施的規劃與營運管理

open access: yes, 2011
隨著生物技術的發展,使得分子生物學家和育種家得以藉由DNA 重組技術針對特定的植物遺傳性狀直接進行改造,此即所謂的基因轉殖技術,它提供了嶄新的植物品種改良方法。此一新技術的應用目前在國際間正引發不同的考量與反應,一方面由於基因改造作物有助於提高並擴大原作物的栽培價值,因而廣受各國重視而競相研發;另一方面則有人對其推廣懷著隱憂,認為可能對地球生態及食品安全帶來負面影響。因此,為顧及應用上的安全,轉基因作物在推廣前須有妥善的評估與研究,以防止可能的副作用。為此,近十餘年來政府不僅努力於相關法規制度的建立 ...
賴吉雄   +4 more
core  

人乳头瘤病毒线性杂交分型技术的建立及评价

open access: yesZhongguo shiyan zhenduanxue, 2010
目的建立人乳头瘤病毒(Human papillomavirus,HPV)线性探针反向杂交(1ine probe assay,LiPA)基因分型技术,通过基因测序技术对LiPA分型检测的效果进行评价。方法利用基因工具软件比对HPV L1基因,设计HPV型别的基因探针,手工将探针点样于条形尼龙膜上,再进行LiPA杂交分型。LiPA检测的样本结果与HPV基因测序的结果进行比较,以评价LiPA检测的效果。结果74例利用LiPA成功地作出了基因分型,其中单独一型HPV感染为40例,涉及13种不同基因型HPV ...
田永强, 朱中元, 王海波
doaj  

Multilayer Architecture of PVD/HVOF Coatings Enables Transition in Wear Mechanism and Enhanced Tribological Performance

open access: yesRare Metals, Volume 45, Issue 9, September 2026.
ABSTRACT TiN films deposited by physical vapor deposition (PVD) are widely used as protective films due to their high hardness and wear resistance. However, their application under high‐load conditions is limited by poor load‐bearing capacity and susceptibility to spalling on soft substrates.
Ziyu Wang   +6 more
wiley   +1 more source

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