Results 71 to 80 of about 22,208 (188)

吉林地区汉族人群脂联素基因多态性与冠心病的相关性

open access: yesZhongguo shiyan zhenduanxue, 2006
目的探讨吉林地区汉族人群脂联素基因(apM1)多态性与与冠心病的关系。方法运用单核苷酸多态性分析技术在251例无亲缘关系的吉林地区汉族人群(正常对照人群131例,冠心病120例)中检测apM1基因2号外显子及3号外显子的多态性。结果吉林地区汉族人群中SNP45(T/G)和SNP331(T/C)多态性的基因型频率和等位基因频率在冠心病组和正常对照组间的分布存在显著性差异 ...
王楠, 李淑梅
doaj  

The study on the association between polycyclic aromatic hydrocarbons exposure and adverse pregnancy outcomes and their mechanisms [PDF]

open access: yes, 2012
目的通过流行病学调查,掌握闽南地区妊娠妇女妊娠结局情况,并探讨多环芳烃(polycyclicaromatichydrocarbons,PAHs)暴露对妊娠结局的影响,结合PAHs代谢酶活性及基因多态性分析,DNA损伤等指标,评价PAHs暴露对胎儿健康的危害。 方法利用问卷形式收集1106例孕妇流行病学资料,以了解环境因素对妊娠妇女妊娠结局的影响。采用气相色谱串联质谱(gaschromatograph-massspectrometer,GC-MS)技术测定206例孕妇外周静脉血、新生儿脐带血中PAHs含量;
钟渊福
core  

Understandings and critiques of biocultural diversity conservation and future recommendations for conservation actors

open access: yesConservation Biology, Volume 40, Issue 1, February 2026.
Abstract As biocultural approaches to conservation gain traction (e.g., through international commitments to Indigenous Peoples and local communities) and external conservation actors increasingly seek to engage with on‐the‐ground holders of biocultural diversity, improved understanding is needed of what biocultural diversity means.
Natalie D. L. York
wiley   +1 more source

Effects of ApoE Isoforms Expression on Brain ApoE Lipidation and Amyloid-β Accumulation [PDF]

open access: yes, 2015
在编码人三种不同apoE蛋白亚型(E2、E3和E4)的APOE等位基因(ε2、ε3和ε4)中,APOEε4等位基因是阿尔茨海默病(Alzheimer’sdisease,AD)最重要的遗传风险因子,APOEε2等位基因则具有保护作用。鉴于apoE蛋白亚型对基于调节apoE蛋白表达的AD治疗可能会有不同的影响,我们通过在人APOE基因定位替换(Targetedreplacement,TR)小鼠脑中过表达不同的人apoE亚型,研究脑中表达不同apoE亚型对apoE脂化和β-淀粉样蛋白(Amyloid-β,Aβ)
胡进
core  

Changes in Key Biodiversity Area networks following national comprehensive assessments

open access: yesConservation Biology, Volume 40, Issue 1, February 2026.
Making comprehensive assessments of Key Biodiversity Area (KBA) networks in a country greatly increases their number and area. Countries that have not yet done so will be missing about half of these globally significant sites and missing the opportunity to get 30 × 30 conservation in the right places. Abstract Key Biodiversity Areas (KBAs) are sites of
Andrew J. Plumptre   +46 more
wiley   +1 more source

中国人内源性高甘油三酯血症中ApoB基因第26外显子XbaI多态性分析

open access: yesZhongguo shiyan zhenduanxue, 2003
目的 对中国人内源性高甘油三酯血症 (hypertriglyceridemics ,HTG)中ApoB基因第 2 6外显子XbaI多态性进行分析。方法 采用聚合酶链反应和限制性片段长度多态性 (PCR RFLP)方法 ,对沈阳地区 115名HTG患者及 15 0名血脂正常健康成人ApoB基因第 2 6外显子XbaI多态性进行分析 ;同时测定血脂及载脂蛋白水平 ,分析ApoB基因XbaI多态性对血脂及载脂蛋白水平的影响。结果 正常对照组及HTG组中基因型均以X -X -为主。HTG组X ...
宫立国   +4 more
doaj  

Metadiscourse and Teacher Moves for Supporting Student Reasoning in Linguistics Classroom Interactions

open access: yesInternational Journal of Applied Linguistics, Volume 36, Issue 1, Page 522-539, February 2026.
ABSTRACT This paper examines the features of metadiscourse across different teacher moves in university linguistics classroom discourse and the teaching strategies reflected in its use. The results reveal that teachers employ diverse metadiscourse during classroom interactions to support student reasoning.
Jingjie Li, Wenjie Hu
wiley   +1 more source

雌激素受体α基因多态性与女孩性早熟关系的研究

open access: yesZhongguo shiyan zhenduanxue, 2010
目的探讨雌激素受体-α(ERα)基因多态性与江西地区女孩性早熟的相关性。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术,检测90例江西地区性早熟女孩和70例江西地区健康体检女孩ERα基因内含子1 Pvu Ⅱ T/C和XbaI A/G酶切位点基因多态性,并观察基因型对血清E2的影响。结果病例组ERα基因XbaⅠ基因型和等位基因频率分布与对照组相比差异有显著性 ...
柯江维   +6 more
doaj  

The Dynamics of Coordination and Actor Movements in Advocacy Coalitions: A Theoretical Longitudinal Perspective Within the ACF

open access: yesPolitics &Policy, Volume 54, Issue 1, February 2026.
ABSTRACT This theoretical article examines the dynamics of stability and change in public policy coalitions using the Advocacy Coalition Framework as a foundation. We focus on how intra‐coalition and inter‐coalition coordination serves as a causal factor influencing the stability of coalition composition and the mobility of actors over time, especially
Dyego Alves da Silva   +2 more
wiley   +1 more source

载脂蛋白A5基因多态性与冠心病患者血脂及冠脉狭窄程度的相关性

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2017
【目的】探讨中国汉族人群载脂蛋白A5(APOA5)基因rs2075291和rs3135507多态性位点与冠心病(CHD)患者血脂水平及冠脉狭窄程度的关系。【方法】应用聚合酶链式反应-限制性片段长度多态性法(PCR-RFLP)对324例CHD患者和152例非CHD对照者进行rs2075291和rs3135507多态性分型并比较不同基因型之间血脂水平的差异。采用Gensini评分系统评价CHD患者的冠脉狭窄程度 ...
王艳玫   +4 more
doaj  

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