Results 41 to 50 of about 19,323 (198)
The mechanism and function of extracellular matrix protein Mindin in the colon cancer progression [PDF]
, 2015 在世界范围内，结直肠癌是临床上常见的恶性肿瘤之一。结肠癌的发病机制也在不断细致、深入的研究。然而结肠癌这种实体肿瘤不像单纯的肠癌细胞系。相反，它是由多种类型的细胞和细胞外基质组成的功能失调的器官。细胞外基质是肿瘤微环境的重要组成部分，包含各种各样的细胞因子和代谢产物，具有向细胞传导各种环境信号的作用。这些信号对于细胞生命过程的方方面面都必不可少，包括增殖、分化和死亡等。然而，细胞外基质蛋白在结肠癌发生发展的演变过程中的作用尚未完全明确。 分泌型的细胞外基质蛋白Mindin作为Mindin-F ...
肖传兴
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Integrative Conservation, Volume 4, Issue 1, Page 45-56, March 2025.Understanding the spatial ecology and movement of snow leopards is crucial for their long‐term conservation. Our first GPS telemetry study in Nepal revealed that snow leopards of Nepal have much larger home ranges than previously thought and frequently cross international borders.
Samundra Ambuhang Subba +21 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2017 目的分析吉林省耐多药结核分枝杆菌临床分离株rpoB、katG基因突变特点,为建立本省快速耐多药检测方法提供参考。方法对吉林省耐多药结核分枝杆菌菌株扩增rpoB、katG基因测序后比对分析。结果耐多药结核分枝杆菌rpoB、katG基因的突变率分别为83.53%和70.6%,突变类型包括点突变、联合突变和缺失。在rpoB基因中,82.30%突变发生在RRDR区域,最常见突变位点为rpoB 531、rpoB 526、rpoB 516。KatG基因突变率为70.6%,最常见突变位点为katG315 ...
张炜煜 +4 more
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REGULATORY MECHANISMS OF NITRIC OXIDE ON THE BASOLATERAL CHLORIDE CHANNELS IN THE THICK ASCENDING LIBM OF KIDNEY [PDF]
, 2016 位于肾脏髓袢升支粗段（TAL）管周膜侧的氯通道在机体对Cl-的重吸收过程中发挥着十分关键的作用。本研究拟利用细胞贴附式膜片钳技术来观察一氧化氮（NO）是否通过抑制管周膜侧氯通道的活性来减少TAL对NaCl的重吸收以及这种抑制作用是否是通过环磷酸鸟苷（cGMP）依赖的蛋白激酶G（PKG）途径来实现的。实验结果表明，体外急性添加一氧化氮合酶（NOS）作用底物L-精氨酸以及NO外源性供体SNAP均能显著抑制TAL管周膜侧10-pS氯通道的活性。然而，存在NOS抑制剂或NO清除剂条件下，我们并未观察到L ...
吴鹏
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Big Cat Mortality in Subsistence Hunts in Amazonia 亚马孙雨林地区生计狩猎中的大型猫科动物致死情况研究
Wildlife Letters, Volume 3, Issue 1, Page 16-21, March 2025.We use data from a participatory biodiversity monitoring program to estimate the annual mortality of jaguars and pumas resulting from subsistence hunts in two Amazonian Extractive Reserves. We estimate that around 50 big cats are killed annually in the study area, which is consistent with an independent estimate for the same area and within the same ...
Elildo A. R. Carvalho Jr. +3 more
wiley +1 more source
Studies of Functions and Mechanisms of JMJD2D in the Development of Colorectal Cancer [PDF]
, 2015 结直肠癌（Colorectalcancer,CRC）是世界范围内的高发性恶性疾病，其发病率和死亡率呈逐年上升趋势，因而引起广大科研工作者对其发生发展的作用机制进行深入研究。文献报导称，在绝大多数结直肠癌的发生发展过程中都伴随着经典Wnt信号通路的异常激活。该通路激活后，其中最重要的效应分子之一β-Catenin入核与TCF/LEF家族成员结合，激活下游促癌基因转录表达，从而促进结直肠癌的发生发展。 组蛋白赖氨酸特异性去甲基化酶4D（Lysine-specificdemethylase4D,KDM4D ...
余力
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Wildlife Letters, Volume 3, Issue 1, Page 22-29, March 2025.Human–wildlife conflict poses a major threat to conservation and livelihoods. Here, we outline two innovative approaches: one where local people monitor wildlife on their land using camera‐traps and receive tangible, significant benefits as a direct result of that recorded wildlife presence, and one where that approach is expanded into wider ...
Amy Dickman +8 more
wiley +1 more source
Genetic analysis and gene mapping of panicle branches stay-green trait in rice [PDF]
, 2016 水稻是重要的粮食作物之一，全球一半以上的人口以大米为主食。随着世界人口的增长，人们正面临着越来越严重的粮食危机。如何增加水稻产量一直是作物育种以及植物学研究的重要目标。近年来水稻遗传育种工作者发现了一些成熟期叶片的叶绿素不降解或仅少量降解而使叶片仍保持绿色的持绿型水稻品种，研究发现其叶片持绿性状多数属多基因控制的数量遗传，少数属隐性主效基因控制的质量性状遗传，相关基因大多已被鉴定及克隆。迄今为止，尚未见穗枝梗持绿性状的研究报道。佳辐占系本课题组育成的优质高产早稻品种，已在生产上大面积推广应用 ...
王永杰
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A spatially explicit assessment of factors shaping attitudes toward African elephant conservation
Conservation Biology, Volume 39, Issue 1, February 2025.Abstract Conservation plans that explicitly account for the social landscape where people and wildlife co‐occur can yield more effective and equitable conservation practices and outcomes. Yet, social data remain underutilized, often because social data are treated as aspatial or are analyzed with approaches that do not quantify uncertainty or address ...
Sarah L. Carroll +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的研究肝癌原癌基因c-MET突变和缺失。方法采用PCR-SSCP和DNA测序方法,对37例肝癌患者肿瘤组织标本的c-MET基因15-19外显子进行检测,研究c-MET基因的缺失和突变情况。结果发现5例有c-MET基因外显子15-19存在点突变,突变率为7.4%。结论c-MET基因的突变与肝癌的发生和发展有一定的联系。
王继生, 周斌, 徐鲁白, 郑志强
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