Results 61 to 70 of about 38,507 (214)

Functional homogenization of terrestrial mammals outside protected areas in the Hengduan Mountains, China

open access: yesConservation Biology, EarlyView.
Abstract Despite the crucial role of human impacts on biodiversity loss, many assessments of this loss focus on single metrics, such as species richness, and overlook the multidimensional effects of human activities. Because of its importance to ecosystem functioning, we investigated the functional diversity of medium‐ and large‐sized mammal ...
Xueyou Li   +8 more
wiley   +1 more source

Improving the inhibitors targeting enterovirus 71 3C proteinase [PDF]

open access: yes, 2015
手足口病(HFMD)的频繁爆发,给许多婴幼儿带来痛苦甚至导致死亡。目前,没有任何疫苗和抗病毒治疗可用于预防和治疗手足口病。肠道病毒71型(EV71)是引起手足口病的主要病原体,它能够侵入中枢神经系统引起严重的后遗症。3C蛋白酶是EV71病毒复制过程中的一个重要蛋白酶,在EV71的成熟过程和拮抗宿主细胞的先天性免疫反应中有着重要作用。因此,EV713C蛋白酶是一个很好的抗EV71药物靶点。 AG7088最先是针对人病毒3C蛋白酶进行设计的,已被证实可有效抑制EV71病毒活性 ...
吴彩明
core  

基因组水平的遗传负荷分析

open access: yesBio-protocol, 2021
靖扬 胡, 卫民 匡, 宏 吴, 黎 于
semanticscholar   +1 more source

Calibration of the species threat abatement and restoration metric's threat abatement component in a Costa Rican landscape

open access: yesConservation Biology, EarlyView.
Abstract Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species.
Louise Mair   +17 more
wiley   +1 more source

The genetic differentiation and mating system of Avicennia marina populations in China [PDF]

open access: yes, 2016
本研究利用SSR分子标记技术,以海南三亚河口、湛江特呈岛和泉州洛阳桥三个地区的白骨壤(Avicenniamarina)种群为研究对象,比较分析三个白骨壤种群的遗传多样性、种群之间的遗传分化和繁育系统模式(包括花粉流、异交率和种子流)。主要结果为: 1、10对核基因组SSR引物在742个个体检测到58个等位基因位点。每个引物扩增等位基因数在5-9个之间,平均5.8个。三个地区种群共出现了15个私有等位基因位点,在等位基因水平上已发现较大的分化与遗传距离。 2、湛江白骨壤种群遗传多样性水平最高 ...
侯蕊
core  

Informal Digital Learning of English (IDLE) as Form‐Focused and Meaning‐Focused Activities: Refining its Measurement and Examining its Predictive Role in L2 Achievement and Confidence

open access: yesInternational Journal of Applied Linguistics, EarlyView.
ABSTRACT Acknowledging the limitations of existing measurement instruments in adequately capturing the distinct cognitive processes (e.g., form‐focused vs. meaning‐focused) involved in informal digital learning of English (IDLE), this paper asserts a pressing need to develop and validate robust instruments that measure form‐focused and meaning‐focused ...
Minlin Zou   +3 more
wiley   +1 more source

雌激素受体基因多态性与绝经后女性代谢综合征的相关性研究

open access: yesZhongguo shiyan zhenduanxue, 2014
目的观察雌激素受体(ER)α和β基因多态与绝经后女性代谢综合征(MS)的关系。方法 311例无亲缘关系的绝经后MS患者和231例年龄相匹配的健康对照人群,采用聚合酶链反应-限制性片段长度多态性(PCRRFLP)技术,检测ERα(XbaⅠ、PvuⅡ)和β基因(RsaⅠ、AluⅠ)多态性,并采用SHEsis在线计算平台进行统计学分析。结果与对照组相比,MS患者体重、BMI、SBP、DBP以及血清FBS、GSP、TG水平显著高于对照组,而HDLC水平显著低于对照组(P0.05);对照组和MS组RR、Rr ...
孙树凯   +5 more
doaj  

Metadiscourse and Teacher Moves for Supporting Student Reasoning in Linguistics Classroom Interactions

open access: yesInternational Journal of Applied Linguistics, EarlyView.
ABSTRACT This paper examines the features of metadiscourse across different teacher moves in university linguistics classroom discourse and the teaching strategies reflected in its use. The results reveal that teachers employ diverse metadiscourse during classroom interactions to support student reasoning.
Jingjie Li, Wenjie Hu
wiley   +1 more source

白细胞介素8和载脂蛋白E基因多态性与迟发性 阿尔茨海默病的相关分析

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2010
【目的】 探讨白细胞介素8基因(interleukin-8,IL-8)基因A-251T和载脂蛋白E(ApoE)基因多态性与迟发性阿尔茨海默病(LOAD)的相关性65377;【方法】 采用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)观察185例广东汉族人群 (研究组:LOAD患者88例,正常对照组97例) IL-8基因A-251T基因65380;ApoE基因多态性的分布并进行关联分析65377;【结果】 ① IL-8 基因A ...
doaj  

苯乙酸对胶质瘤细胞C6中同源盒基因表达的影响

open access: yesZhongguo shiyan zhenduanxue, 2004
目的 观察诱导分化剂苯乙酸 (PA)抑制胶质瘤细胞C6增殖过程中 ,生物发育调节的主控基因———同源盒基因 (Hox基因 )表达的变化。方法 根据引物的不同 ,将已知的 2 2种HOX基因分为 3组 (P1,P2 ,P3)。用逆转录PCR(RT PCR)及图像分析法检测应用PA前后 ,Hox基因组在胶质瘤细胞C6中表达的变化。针对应用PA前后表达显著不同的Hox基因组 ,用组内包含的特异Hox基因的引物 ,重复上述实验 ,检测特异Hox基因的表达。Hox基因 (组 )表达水平用基因 (组 ) β ...
田宇, 赵丛海, 杨朝华
doaj  

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