Results 101 to 110 of about 953,736 (207)

Laser‐Induced Graphene/AuNPs‐Gated OECT Biosensor for Sensitive Detection of PD‐L1‐Positive Exosomes Associated With Non‐Small Cell Lung Cancer

open access: yesRare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Lung cancer remains a major cause of cancer‐related mortality worldwide, and non‐small cell lung cancer (NSCLC) accounts for the largest proportion of diagnosed lung cancer cases. Exosomal programmed death‐ligand 1 (PD‐L1) has attracted increasing attention as a potential liquid‐biopsy biomarker associated with tumor immune regulation; however,
Chen Su   +6 more
wiley   +1 more source

细胞毒性T 淋巴细胞相关抗原4 基因型与中国南方人群Graves ’ 病的关系

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2005
【目的】探讨细胞毒性T淋巴细胞相关抗原-4(cytotoxic T lymphocyte associated antigen 4)基因第一外显子A/G(49)多态性与中国南方汉族人群Graves′病的关系。【方法】用PCR-RFLP确定CTLA-4基因第1外显子49位点基因型,分析广东地区汉族人Graves′病患者(GD组)120例及123名正常人(对照组)CTLA-4基因多态性。并把GD患者按性别、家族史、TRAb、突眼等分别分两亚组后分析CTLA-4基因第1外显子A49G位点基因型及等位基因的频率。
姚斌   +4 more
doaj  

白花柽柳的类金属硫蛋白基因

open access: yes, 2010
本发明涉及一种白花柽柳的类金属硫蛋白基因,通过消减文库获得了该基因的3’cDNA片段,然后通过RACE技术克隆出全长cDNA序列,该基因3’非编码区长度为262bp,5’非编码区长度为150bp,编码区长度为210bp,包含69个氨基酸,编码蛋白的分子量为7.32千道尔顿(KD)。类金属硫蛋白基因是属于金属硫蛋白家族中的一类基因,是一种具有抗重金属胁迫和抗旱、耐盐的基因。金属硫蛋白是一类低分子质量、富含巯基和金属的非酶类蛋白质,广泛存在于生物界 ...
王玉成, 董玉芝., 张道远
core  

Lignin‐Derived Carbon Quantum Dots as Hole‐Trapping Promoters in LCDs/Bi‐MOF/ZIS With S‐Scheme Heterojunction for Efficient Photocatalytic Hydrogen Peroxide Production in Pure Water

open access: yesRare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Photocatalytic hydrogen peroxide (H2O2) production from water and oxygen driven by solar energy represents a highly promising green and sustainable strategy. Herein, lignin‐derived carbon quantum dots (LCDs) were strategically introduced at the heterojunction between a Bi‐based metal organic framework (Bi‐MOF) and ZnIn2S4 (ZIS).
Wanpeng Sun   +8 more
wiley   +1 more source

鼻咽癌颈淋巴结转移相关甲基化基因的筛选

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2016
摘 要: 【目的】 分析鼻咽癌全基因组基因甲基化状态,筛选鼻咽癌颈淋巴结转移相关的甲基化基因?【方法】 收集I期(T1N0M0)鼻咽癌石蜡标本及有颈部淋巴结转移的鼻咽癌组织标本(T1-4N1-3M0)各4例,分别提取DNA,富集两组样品基因组甲基化片段后采用甲基化芯片对两组标本进行高通量测序分析,对杂交信号进行扫描及初步数据处理,分析并筛选出两组标本的差异甲基化基因?
doaj  

Rfx2基因在小鼠睾丸中的表达研究

open access: yesZhongguo shiyan zhenduanxue, 2010
目的利用基因芯片筛选与精子发生相关的基因,并研究其表达特征。方法将4 d、9 d、18 d、35 d、54 d和6月龄小鼠睾丸组织cDNA与Affymetrix全基因组芯片进行杂交,筛选出差异表达的基因。通过RT-PCR分析差异表达基因在小鼠睾丸不同发育阶段中的表达。结果分析Affymetrix全基因组芯片杂交结果后,筛选得到1个差异表达杂交点,通过在NCBI网站与小鼠全基因组序列Blast分析可知该差异表达基因是Rfx2基因。该基因在4 d、9 d、18 d、35d、54 ...
王朝亮   +7 more
doaj  

Lanthanide Nanoparticles With Dual Enzyme Mimetic Activities for Targeted Treatment of Gram‐Negative Bacterial Infections

open access: yesRare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Gram‐negative (G−) bacterial infections, fueled by intrinsic antibiotic resistance stemming from their unique outer membrane architecture, pose a critical global clinical challenge. This study introduces a pioneering dual‐enzyme‐mimetic nanotherapy based on NaYbF4 nanoparticles (NaYbF4 NPs) that achieves synergistic antibacterial and anti ...
Yuxiang Zhang   +6 more
wiley   +1 more source

麻疯树(Jatropha curcas)毒蛋白curcin基因家族成员的分离和描述

open access: yes四川大学学报. 自然科学版, 2005
麻疯树curcin基因家族中4个成员通过PCR扩增被分离.它们都不含有内含子,序列分析表明它们编码Ⅰ型核糖体失活蛋白(Ribosome-Inactivating Proteins,RIPs),证明curcin基因如同大多数RIPs一样由多基因家族编码.四个curcin基因家族成员和另两个已知curcin基因家族成员的开放阅读框(Open Reading Frame,ORF)的序列比对结果显示curcin基因家族成员至少可分为两个亚类群,亚类群之间的氨基酸序列相似性低于88 ...
张金平, 秦小波, 徐莺, 陈放
doaj  

转基因鱼的研究进展

open access: yes, 1999
自1984 年第一例转基因鱼在我国诞生以来,转基因鱼研究取得长足进步。研究表明外源基因可以整合、表达,并能遗传给后代,然而外源基因整合位点难以控制,遗传不稳定等问题仍未解决。所幸我国鱼类核移植技术较为成熟,结合细胞基因转移、基因打靶和核移植技术 ...
赵浩斌,陈尚萍,朱作言
core  

Boosting Decomposition and Combustion of TKX‐50 and HTPB/TKX‐50 Propellants With NH2‐MIL‐88B(Fe) MOF

open access: yesRare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Dihydroxylammonium 5,5′‐bistetrazole‐1,1′‐diolate (TKX‐50) is a promising energetic material that possesses both exceptional energy density and low sensitivity. Nevertheless, its application is hindered by incomplete pyrolysis during combustion or explosion. Various strategies, including eutectic formation, composite preparation, and catalysis,
Jingwen Chen   +10 more
wiley   +1 more source

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