Results 31 to 40 of about 68,002 (248)
Rare Metals, EarlyView.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的研究不同类型乙型肝炎病毒（HBV）感染者中HBV基因型分布情况及其临床意义。方法应用基因型特异性引物聚合酶链反应法（PCR）,对180份HBV感染者血清进行基因型分型。结果180份标本中,162份（90%）可检出基因型,18份（10%）未检出基因型。162份HBV基因型分布为:B基因型1例（0.6%）,C基因型159例（98.1%）,B+C混合基因型2例（1.2%）,未检出A、D、E、F基因型。结论邯郸地区HBV感染者中,基因型分布较单一,C基因型占绝对优势,同时存在少量B基因型及B+C混合基因型 ...
邓健 +6 more
doaj
p38MAPK induces apoptosis of glioma cell [PDF]
, 2001 目的 研究 p38MAPK基因转染大鼠胶质瘤细胞系C6后对其生物学特性的影响 .方法 利用脂质体介导法将p38MAPK基因导入大鼠胶质瘤细胞系 C6中 ,用免疫细胞化学染色检测其在细胞转染前后的表达情况 ,用 HE染色、流式细胞仪等方法研究其对细胞形态、粘着状况和生长周期的影响 .结果 转染 p CMV5 - p38MAPK质粒组 p38MAPK蛋白表达阳性 ,细胞形态发生变化 ,贴壁性降低 ,出现大量凋亡细胞 .结论 转染 ...
叶菁(第四军医大学西京医院病理科) +6 more
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Rare Metals, EarlyView.ABSTRACT Ni3S2 has emerged as a promising catalyst for the electrochemical oxidation of biomass‐derived 5‐hydroxymethylfurfural (HMF) to 2,5‐furandicarboxylic acid (FDCA), driven by its distinctive physicochemical properties. However, its practical catalytic efficiency is severely hindered by abundant electrochemically inactive surface sites and poor ...
Cheng‐Feng Yi +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2011 癌基因的活化（如ras基因、bcr-abl基因）或/和抑癌基因的失活（如P53基因、Rb基因）与肿瘤的发生密切相关。ID4基因是1994年Riechmann等首次从小鼠中分离鉴定的,发现该基因在胚胎发育的9.5d-13.5d是上调的,且在成人的脑、睾丸和肾脏器官高表达[1]。
冯燕, 李薇, 党艳辉, 卢学春
doaj
Functional Study of SIDP364 and SIDP361 Genes of DUF1644 Family in Salt Stress Response [PDF]
, 2012 水稻是重要的粮食作物，也是单子叶植物研究的模式植物。高盐、冷害和干旱等各种非生物逆境对作物的生长发育、产量和品质都有影响，而土壤盐渍化是农作物最主要的非生物胁迫之一，因此对水稻耐盐性进行研究意义重大。水稻的耐盐性是由多基因控制的复杂性状，涉及到胁迫应答、离子平衡和物质运输等诸多方面。通过基因芯片和生物信息学分析，从水稻中分离了两个基因SIDP364(StressinducedDUF1644Protein364)和SIDP361(StressinducedDUF1644Protein364 ...
李敏
core
Rare Metals, EarlyView.ABSTRACT Internal oxidation has been identified as an effective method for enhancing the strength of AgMg alloys. However, the concurrent occurrence of embrittlement remains inadequately understood, thus limiting their broader application. This study investigates the oxidation behavior of AgMg alloys with Mg concentrations ranging from 1 at% to 7 at ...
Hai‐Cheng Zhu +12 more
wiley +1 more source
膀胱移行细胞癌组织基因的P14ARF、DAPK、RARβ甲基化变异分析
Zhongguo shiyan zhenduanxue, 2012 目的通过检测新鲜冰冻膀胱癌组织中P14ARF、DAPK、RARβ基因的启动子CpG岛基因的甲基化状态,探讨P14ARF、DAPK、RARβ在膀胱癌发生过程中的作用及诊断意义。方法采用甲基化特异性PCR技术检测48例手术切除的膀胱癌组织和其中13例相应癌旁组织标本、17例非肿瘤患者正常膀胱组织中DAPK、RARβ、P14ARF基因的甲基化情况。结果 48例膀胱癌组织中发现P14ARF基因异常甲基化13例（27.0%）,DAPK基因异常甲基化13例（27.0%）;RARβ基因异常甲基化44例（91.6 ...
王凯臣 +5 more
doaj
Analysis on amide synthase and methyltransferase in biosynthesis of streptovaricin from the strain NRRL 2494 [PDF]
, 2015 曲张链菌素（streptovaricin）是由壮观链霉菌（Streptomycesspectabilis）NRRL2494产生的安莎类抗生素，与抗结核药物利福霉素具有相似的化学结构骨架，具有抗菌及免疫抑制等多种生物活性。本论文在对NRRL2494菌株基因组测序的基础上，获得曲张链菌素生物合成基因簇，并通过构建稳定的遗传操作体系，研究其生物合成途径中重要基因的功能，为利用组合生物学手段获得成药性好的曲张链菌素类化合物奠定基础。 本论文首次分析了NRRL2494菌株的基因组全长17.5MB序列 ...
宋姣姣
core
Rare Metals, EarlyView.ABSTRACT Photodetectors, based on GaAs nanowires (NWs), hold significant promise in the fields of high integration micro‐ and nano‐optoelectronics applications because of their outstanding electronic and optical properties. To date, significant efforts have been directed toward enhancing the performance of photodetectors, aiming for high detectivity ...
Yu Hao +11 more
wiley +1 more source