Results 31 to 40 of about 71,543 (200)
Conservation Biology, EarlyView.Abstract Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species.
Louise Mair +17 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的研究不同类型乙型肝炎病毒（HBV）感染者中HBV基因型分布情况及其临床意义。方法应用基因型特异性引物聚合酶链反应法（PCR）,对180份HBV感染者血清进行基因型分型。结果180份标本中,162份（90%）可检出基因型,18份（10%）未检出基因型。162份HBV基因型分布为:B基因型1例（0.6%）,C基因型159例（98.1%）,B+C混合基因型2例（1.2%）,未检出A、D、E、F基因型。结论邯郸地区HBV感染者中,基因型分布较单一,C基因型占绝对优势,同时存在少量B基因型及B+C混合基因型 ...
邓健 +6 more
doaj
Systematic Analysis of ApiAP2 Transcription Factor Gene Family in the Rodent Malaria Parasite Plasmodium yoelii [PDF]
, 2016 疟疾是疟原虫（Plasmodiumspp.）感染导致的蚊媒传染性疾病，疟原虫生活周期复杂，经历了多宿主和多细胞形态的转化，每一步都需要精确地基因时空表达调控，转录因子介导的DNA转录水平的调控起到重要作用。 ApiAP2基因家族是疟原虫基因组中预测的为数极少的转录因子基因家族，在人疟原虫和啮齿类动物疟原虫中高度保守。在顶复体亚门生物（包括疟原虫）和植物中，ApiAP2基因编码蛋白均含有一个或者多个60个氨基酸大小的AP2DNA结合结构域，起到激活或抑制转录的作用。 之前的转录谱和蛋白质组学分析发现 ...
赵伊华
core
Biodiversity‐driven spatial conservation planning to delineate temporally stable regions
Conservation Biology, EarlyView.Abstract The accelerating loss of biodiversity underscores the critical need for effective conservation strategies, particularly in the face of climate change and anthropogenic pressures. We devised a conservation planning framework that adopts a temporal stacking approach to species distribution models and landscape connectivity analyses. These models
Mattia Iannella +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2011 癌基因的活化（如ras基因、bcr-abl基因）或/和抑癌基因的失活（如P53基因、Rb基因）与肿瘤的发生密切相关。ID4基因是1994年Riechmann等首次从小鼠中分离鉴定的,发现该基因在胚胎发育的9.5d-13.5d是上调的,且在成人的脑、睾丸和肾脏器官高表达[1]。
冯燕, 李薇, 党艳辉, 卢学春
doaj
Regulation of YY1 by SET7/9-mediated methylation [PDF]
, 2016 目前随着生活品质的改善和人类寿命的延长，许多老年疾病例如癌症成为人类常见的疾病，目前治疗癌症除了常规手段之外，一种伤害比较小的即表观遗传治疗手段逐渐被提上研究日程。 蛋白甲基化修饰系统对于基因组精密转录至关重要。蛋白甲基化酶和去甲基化酶通过对组蛋白动态修饰调控基因转录是表观遗传学“组蛋白密码子学说”的核心内容之一，其失调会导致包括癌症在内的多种疾病的发生。众所周知基因转录也受到转录因子的精密调控，然而甲基化修饰系统如何通过以转录因子为代表的非组蛋白底物调控基因转录的模式还不完全清楚 ...
徐欢腾
core
Defining and identifying relevant stakeholders to advance effective conservation
Conservation Biology, EarlyView.The challenge of defining stakeholders in environmental science and an approach for refining existing definitions. Abstract Stakeholder is a contested term that has spawned a multitude of ad hoc definitions. The ambiguity of these definitions has oftentimes impeded transdisciplinary research in environmental governance and conservation science because ...
Milan Büscher +5 more
wiley +1 more source
膀胱移行细胞癌组织基因的P14ARF、DAPK、RARβ甲基化变异分析
Zhongguo shiyan zhenduanxue, 2012 目的通过检测新鲜冰冻膀胱癌组织中P14ARF、DAPK、RARβ基因的启动子CpG岛基因的甲基化状态,探讨P14ARF、DAPK、RARβ在膀胱癌发生过程中的作用及诊断意义。方法采用甲基化特异性PCR技术检测48例手术切除的膀胱癌组织和其中13例相应癌旁组织标本、17例非肿瘤患者正常膀胱组织中DAPK、RARβ、P14ARF基因的甲基化情况。结果 48例膀胱癌组织中发现P14ARF基因异常甲基化13例（27.0%）,DAPK基因异常甲基化13例（27.0%）;RARβ基因异常甲基化44例（91.6 ...
王凯臣 +5 more
doaj
Appraisal of the Sri Lanka Dairy Sector volume 2: Main report [PDF]
, 2010 从蛙虹彩病毒（Rana grylio virus,RGV）中克隆出一个虹彩病毒科的序列保守基因RGV-12L,序列分析表明该基因全长894 bp,编码一个含297个氨基酸的多肽,分子量为33 kD。构建包含该基因全长的原核表达载体,进行原核表达,获得了分子量约53 kD的融合蛋白。将融合蛋白经腹腔注射免疫小鼠,制备出鼠抗RGV-12L血清。通过RT-PCR和Western blotting分析RGV感染细胞后RGV-12L的转录时序,感染4h可以在RNA水平检测到RGV-12L的转录 ...
Ibrahim, Mohamed N.M. +3 more
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Drivers of bat researchers’ intent to adopt field hygiene practices
Conservation Biology, EarlyView.Abstract Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate
Joanna L. Coleman +6 more
wiley +1 more source