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中药调控PI3K/Akt信号通路治疗帕金森病的机制研究进展

Zhongshan Daxue xuebao. Yixue kexue ban
帕金森病（PD）是一种以中脑黑质多巴胺能神经元丢失为特征的神经退行性疾病，现有治疗手段难以逆转其神经变性进程，因此迫切需要神经保护治疗。磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）信号通路作为调控细胞存活的关键通路，已成为PD干预的重要靶点。近年来，中药以其多靶点、整体调节的特色，在基于PI3K/Akt通路的PD神经保护研究中展现出潜力。然而，该领域研究目前多停留于临床前阶段，缺乏将患者临床终点（如UPDRS评分）与通路生物标志物（如p-Akt水平）相关联的高质量临床证据，制约其临床转化。因此 ...
渠燕飞, 李彦杰
doaj  

[Innovative undergraduate teaching practice integrating MassWorks mass spectrometry analysis technology with gas chromatography-low resolution mass spectrometry]. [PDF]

Se Pu
Li ZX, Sun Y, Li B, Yu WH, Ouyang WM, Xu YC, Tian K, Zhao JB.   +7 more
europepmc   +1 more source

[Effects of <i>Thap6</i> gene knockout on emotional and social behaviors in mice]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Lu Q, Wu J, Zhang R, Dong Y, Chen X, Zhou X, Fan L, Zhang Y.   +7 more
europepmc   +1 more source

[WD40 repeat-containing protein 6 aggravates diabetic kidney disease by promoting lipid accumulation in kidney]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Xin P, Sun L, Niu S, Sun X, Sun X.
europepmc   +1 more source

[Bushen Yijing Formula attenuates amyloid β-protein deposi-tion and oxidative damage in <i>Caenorhabditis elegans</i>]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Lu Y, Li D, Hu Y, Lu L, Yu G.
europepmc   +1 more source

[Construction of an anxiety recognition model for patients with malignant gastrointestinal tumors based on multidimensional features and multiple interpretable machine learning]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Chen M, Guo R, Zhao W, Wang Y, Zuo L, Liu M, Li B.   +6 more
europepmc   +1 more source

[Preparation of a novel polyhydroxy silica stationary phase and application in the separation of alginate oligosaccharides]. [PDF]

Se Pu
Jiao RW, Zhang DD, Hu XY, Zhu WT, Li X, Cai YD, Ren DD, Wang QK, Wu L, Zhou H.   +9 more
europepmc   +1 more source

[Role of dysregulation brain lipid metabolism in depression]. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Yu P, Huang S, Jiang Z, Wang X, Jiang D.
europepmc   +1 more source

[<i>Cuscuta chinensis</i> Lam. reduces oxidative injury in Alzheimer<b>'</b>s disease model cells]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Li D, Liu X, Lu Y, Yu G.
europepmc   +1 more source

[Association between umbilical cord blood proteome and early infant neurodevelopmental risk]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Mo J, Wang H, Liu J, Li Q, Su T, Ji Y.
europepmc   +1 more source