Results 1 to 10 of about 1,489 (154)
PT109改善链脲佐菌素诱导的散发性阿尔茨海默病小鼠认知功能障碍的作用及机制 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的观察PT109能否改善侧脑室注射链脲佐菌素（icv-STZ）诱导的散发性AD小鼠模型的认知功能障碍并对其机制进行初步探讨。方法32只7周龄雄性C57BL/6小鼠分为正常组（7只）、模型组（7只）、PT109低剂量组（9只）、PT109高剂量组（9只）。将STZ于第1和3天注射入小鼠侧脑室建立散发性阿尔茨海默病小鼠模型；（3mg/kg，每个注射位点5μL）造模后，分别腹腔注射PT109（30、100 mg·kg-1·d-1），2周后通过Morris水迷宫和避暗实验评价小鼠学习记忆能力；随后通过免疫荧光、
陈秋荷 +5 more
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Non-targeted Metabolomic Study on Anti-aging Effect of Ripe Pu-erh Tea on D-Galactose-Induced Aging Mice [PDF]
, 2023 Delaying aging has become a hot spot of social concern and research. Our previous studies have shown that ripe Pu-erh tea can delay aging in mice by regulating the intestinal flora, but the metabolites in response to endogenous substances in mice are not
LEI Shuwen, ZHANG Zhifang, XIE Guihua, SHAN Bo, MIAO Yue, ZHAO Chunyan, CHEN Dehong, HOU Yan, GONG Jiashun,
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Construction and characterization of mice with conditional knockout of Stat3 gene in microglia [PDF]
, 2023 Objective·To construct mice with conditional knockout of Stat3 gene in microglia based on the Cre-Loxp system and validate their knockout efficiency.Methods·Cx3cr1creERT2 and Stat3fl/fl genotypic mice were bred for conditional knockout mice (CKO) and ...
HE Zhiyan +5 more
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Change of transcription factor EB activity and autophagy in hippocampus of type 2 diabetic encephalopathy mice [PDF]
, 2023 Objective·To investigate the changes of transcription factor EB (TFEB), the activity of the upstream proteins and autophagy in the hippocampus of mice with type 2 diabetic encephalopathy.Methods·Twenty healthy 8-week-old male C57BL/6J mice were randomly ...
CHEN Yixin +3 more
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Effects of Different Concentrations of Alcohol On Spatial Learning and Memory Ability and Hippocampal GFAP/NEUN in Mice [PDF]
, 2017 目的 探究长期饮酒对小鼠行为学能力以及空间学习记忆能力的影响。方法 雄性KM小鼠45只,随机分成对照组（Con）,低剂量组（Low）和高剂量组（High）。分别每天对照组0.10 ml/10 g自来水,低剂量组0.05 ml/10 g的56度红星二锅头,高剂量组0.10 ml/10 g的56度红星二锅头进行灌胃。连续灌胃13 d后进行衣架实验测行为学能力,最后取海马做免疫荧光染色观察海马神经元和星形胶质细胞。结果衣架实验得分,自主活动数值总体显示Low组高于其他两组,而且与Con组差异显著 ...
夏天 +7 more
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Research and development progress of Semen ziziphi spinosae oil [PDF]
, 2020 Semen ziziphi spinosae oil is a kind of safe edible oil for health care comes from Suanzaoren which have the functions of both medicine and food.This article reviews the extraction technology，composition analysis and biological activity of Semen ziziphi ...
LI Xiao-yan +4 more
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Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
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Research progress on POMT1 gene variation in α-dystroglycanopathy [PDF]
, 2023 Protein O-mannosyl-transferase 1 （POMT1） gene-encoded protein participates in the initial step of protein O-mannosylation modification and plays an important role in various physiological processes，such as cell connection and neuronal migration，etc.
Shi Runqian, Xu Ying, Chang Yuanyuan, Zhang Jianfang
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鼠李糖乳杆菌对老年小鼠术后海马区小胶质细胞激活及Tau蛋白磷酸化的影响 [PDF]
目的探讨术前益生菌鼠李糖乳杆菌（LGG）灌胃对麻醉手术老年小鼠海马区小胶质细胞及Tau磷酸化的影响。方法18月龄C57BL/6J小鼠30只随机分为3组，10只/组：对照组，麻醉手术组，麻醉手术+鼠李糖乳杆菌组。生理盐水/LGG 109 CFU 150 μL灌胃，每日 1 次，连续20 d后接受异氟醚麻醉+剖腹探查手术，术后12 h免疫荧光染色检测海马区小胶质细胞激活状态，ELISA 检测IL-6的浓度变化，Western blot 检测Tau蛋白磷酸化位点Tau-pS202/pT205和total ...
刘付宁, 刘玲
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野生动物学报, 2021 主要综述了噪音对动物体学习和记忆的影响及其基本机制。研究结果表明，噪声暴露可以引起过度氧化应激、乙酰胆碱酯酶活性增加、髋关节内侧前额叶皮质区树突状细胞数量减少、血浆皮质酮水平升高，并导致空间学习记忆障碍。其中脑组织的氧化应激、胆碱能的下降、动物的恐惧调节、激素分泌、噪音性听力损失以及髋关节的改变和N甲基D天冬氨酸（NmethylDaspartate，NMDA）受体的介导可能是噪音引起认知障碍的主要机制。
彭鸿碧 1, 2, 3 朱万龙 1, 3
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