Results 91 to 100 of about 891 (144)

知母皂苷元对体外培养皮层神经元树突发育的影响及信号转导机制 [PDF]

目的探讨知母皂苷元(Sarsasapogenin,SAR)对大脑皮层神经元树突发育的促进作用及其信号转导机制。方法选用出生0～24 h的Sprague-Dawley(SD)大鼠乳鼠,取皮层神经元进行体外细胞培养,4 d后用于实验。倒置相差显微镜测量培养神经元树突分支总长度(TDBL)、一级树突数目(PDN)、最大分支级数(MBO)和神经元胞体面积。West-ern blot法观察神经元p-PDK1、p-Akt473及p-mTOR蛋白表达。结果形态学观察结果显示SAR(10、30、100μmol.L-1 ...
张永兴, 王金宁, 董燕, 隋海娟
core  

褪黑素对不同年龄SAM-P8小鼠学习记忆相关脑区的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2014
摘 要: 【目的】 研究褪黑素的短期干预对不同年龄SAM-P8脑内膈隔-海马胆碱能系统和海马结构退变的影响?【方法】 选用SAM-P8鼠36只,分为中年低?高浓度治疗组(ME1G?ME2G),老年低?高浓度治疗组(AE1G?AE2G)及其相应的对照组ACG?MCG),共6组?中年?老年治疗组分别于小鼠4月龄?7月龄时每日皮下注射褪黑素(5 mg或10 mg/kg)30 d?对照组注射相同剂量的生理盐水,给药结束后继续饲养到11月龄,采用跳台试验测试其学习及记忆能力 ...
doaj  

[<i>Lactobacillus plantarum</i> alleviates lead exposure-induced learning and memory impairment in mice by regulating bile acid metabolism and inhibiting hippocampal NLRP3 expression]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Li L, Yu W, Tan M, Li Y, Liu A, Meng X.
europepmc   +1 more source

[Fluoxetine enhances combined learning and memory abilities of mice by promoting neural cell functions in the barrel cortex]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2020
Zhang T, Zhang W, Sun Y, Huo Q.
europepmc   +1 more source

[Application and progress of artificial intelligence agents in drug development]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Zhao D, Hsieh C.
europepmc   +1 more source

[Drug repositioning prediction based on dynamic feature learning on heterogeneous graphs]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhu H, Guo Y, Xin X, Li C, Zhou D.
europepmc   +1 more source

[ResLSTM-TemporalSE: an automated classification model for multi-lead ECG signals]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Qu M, Fu R.
europepmc   +1 more source

[Effects of 40 Hz light flicker stimulation on hippocampal-prefrontal neural activity characteristics during working memory tasks in Alzheimer's disease model rats]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Liu S, Wang L, Li S, Xu G.
europepmc   +1 more source

[Evaluation of an interpretable 12-lead ECG automatic diagnosis model based on deep feature fusion]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Lu X, Chen H, Wu Q, Wen Y, Liu G, Chen C.   +5 more
europepmc   +1 more source

[<i>Qixiong Zuogui</i> Granules enhance synaptic plasticity in aging rats by regulating the BDNF/TrkB signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Wang Q, Zhao X, He Y, Liu F, Zhang Y.
europepmc   +1 more source