Zhongguo shiyan zhenduanxue目的 探究Dectin-1通过巨噬细胞极化影响STEMI的机制研究。方法 将45只SPF级SD大鼠随机分为假手术组(n=15)、模型组(n=15)、si-Dectin-1组(n=15),模型组与si-Dectin-1组分别通过尾静脉注射NC-质粒和si-Dectin质粒，2周后建立ST段抬高型心肌梗死(ST-Segment Elevation Myocardial Infarction, STEMI)模型，2周后分离心脏组织，qPCR检测心脏组织Dectin-1表达水平，TTC染色检测心肌坏死面积 ...
孙倩, 苏艳, 张雅兰, 李晓林
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Dectin-1通过巨噬细胞极化影响STEMI的机制研究 附视频
Zhongguo shiyan zhenduanxue目的 探究Dectin-1通过巨噬细胞极化影响STEMI的机制研究。方法 将45只SPF级SD大鼠随机分为假手术组(n=15)、模型组(n=15)、si-Dectin-1组(n=15),模型组与si-Dectin-1组分别通过尾静脉注射NC-质粒和si-Dectin质粒，2周后建立ST段抬高型心肌梗死(ST-Segment Elevation Myocardial Infarction, STEMI)模型，2周后分离心脏组织，qPCR检测心脏组织Dectin-1表达水平，TTC染色检测心肌坏死面积 ...
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Ameliorative effects on osteoporosis of small extracellular vesicles derived from bone marrow mesenchymal stem cells [PDF]
, 2023 Objective·To investigate the effects of small extracellular vesicles (sEVs) derived from human bone marrow mesenchymal stem cells (BMSCs) on the regulation of osteoclast differentiation and macrophage polarization in mice, and mouse model of osteoporosis.
GUO Shangchun, LI Xuran, TAO Shicong
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SIRT2 regulates macrophage chemotaxis by de-modifying histone H4K8 lactylation [PDF]
, 2023 Objective·To explore the regulatory role of silent information regulator 2 (SIRT2) in modulating the immune phenotype of macrophages after infection by removing the lactylation at H4K8 site of histone and the corresponding mechanism.Methods·Human THP-1 ...
CAO Qing +4 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2023 目的研究丁香酚对人脐带间充质干细胞（HUC-MSCs）抑制肝星状细胞（HSCs）炎性活化以及巨噬细胞促炎表型作用的影响及其相关机制；方法体外培养并鉴定HUC-MSCs，并采用MTT法评估丁香酚对HUC-MSCs的毒力作用；体外划痕实验探究丁香酚对HUC-MSCs迁移能力的影响；丁香酚处理HUC-MSCs后的旁分泌产物（EU-MSCs-CM）、HUC-MSCs旁分泌产物（MSCs-CM）处理经TGF-β1处理活化的LX-2细胞，WB实验检测LX-2的α-SMA、COL1A1、Smad2/3、p-Smad2/
吴逐宇, 汪显耀, 陈艳, 何志旭
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Mechanism of alternative splicing in gene transcription and research progress in head and neck squamous cell carcinoma [PDF]
, 2023 Misregulation of alternative splicing may result in splicing defects in different types of cancers under multiple pathological conditions. Alternative splicing events may serve as potential molecular markers during the diagnosis and treatment for cancer.
Meng Guangxue, Ma Hong, Liao Dezhong
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Latest Research Development in Histone Acetylation in the Pathogenesis of Asthma [PDF]
, 2022 Asthma is primarily marked by airway hyperresponsiveness, inflammation, and remodeling. Histone acetylation is one of the most common epigenetic modifications that regulates histone acetyltransferase and histone deacetylase, and imbalanced regulation may
CHEN Shaopeng, ZENG Minjuan, LAI Tianwen
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Research Progress on the Influence of Intermittent Fasting on Cardiovascular Disease Risk Factors [PDF]
, 2022 In recent years, the prevalence and mortality of cardiovascular diseases in China have shown a significant upward trend, cardiovascular disease has become a major disease endangering the health of Chinese residents.
CUI Yanru, CEN Qiuyu, WEI Juanfang, WANG Wenchun, ZHANG Anren
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Fructose regulates M1 macrophage polarisation by promoting glycolysis [PDF]
Objective To investigate the regulatory effect of fructose (Fru) on the polarization of M1 macrophages induced by lipopolysaccharide (LPS) and interferon gamma (IFN-γ) and its possible mechanism.
CHEN Sihong +9 more
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Research progress on roles of ultraviolet irradiation in diseases [PDF]
, 2023 The electromagnetic spectrum emitted by the sun includes visible light, infrared, and ultraviolet (UV). Among them, UV is one of the hotspots of research.
Qianqian ZHU +3 more
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