Research progress on lactylation in atherosclerosis [PDF]
Atherosclerosis (AS) serves as the primary pathological basis for cardiovascular and cerebrovascular diseases. Lactylation, a novel post-translational modification (PTM) linked to lactate molecules, functions as a critical interface between cellular ...
LAN Yining, MO Qin, QIN Chao
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Zhongguo shiyan zhenduanxue, 2018 目的检测姜黄素对LPS诱导小鼠巨噬细胞极化的影响,并检测不同极化状态下细胞培养上清对小鼠胰岛β细胞的损伤作用;研究姜黄素通过拮抗LPS诱导巨噬细胞M1极化保护胰岛β细胞的效应与机制。方法体外培养小鼠小鼠巨噬细胞RAW264.7细胞,通过LPS（2μg/ml）诱导建立M1极化模型,采用姜黄素（7.5 1μmol/l）单独或与LPS共同处理细胞。通过流式细胞术检测巨噬细胞CD40、CD86和CD206表达,并通过ELISA技术检测细胞培养上清液中TNF-α含量 ...
史立言 +4 more
doaj
The role of wound macrophage anti-inflammatory polarization and MANF production in the treatment of diabetic foot with tibial cortex transverse transport [PDF]
Objective To investigate the correlation between midbrain astrocyte-derived neurotrophic factor (MANF) levels in peripheral blood and local wound of diabetic foot patients and the anti-inflammatory polarization of macrophages induced by tibial cortex ...
HUA Qikai +3 more
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Ginseng-derived Nanoparticles Inhibit Lung Cancer Cell Growth by Promoting Macrophage M1 Polarization [PDF]
Objective: To explore the molecular mechanism by which ginseng-derived nanoparticles (GDNPs) inhibit the growth of human non-small cell lung cancer cells (A549) by altering the polarization state of macrophages.
Daqing ZHAO +7 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】研究间充质干细胞（MSC）是否可以通过诱导肺泡巨噬细胞向M2型极化来改善急性肺损伤。【方法】①贴壁法提取脐带MSC，用流式细胞仪分析细胞表型，细胞化学染色法观察细胞体外成骨和成脂肪能力。②小鼠肺泡巨噬细胞系（MH-S细胞）加入脂多糖（LPS）刺激，和MSC隔离共培养，并加入MSC可溶性因子抑制剂，设置LPS组、LPS+MSC组和MSC抑制剂组，共培养48h后用流式和qPCR技术分析巨噬细胞极化状态。③30只balb/c雄性小鼠随机均分成control组、ALI组、ALI+MSC组（均n=10 ...
孙瑶 +4 more
doaj
Research progress on graphene and its derivatives modulating the bone regeneration microenvironment [PDF]
Graphene family nanomaterials (GFNs) are highly popular in the field of bone tissue engineering because of their excellent mechanical properties, biocompatibility, and ability to promote the osteogenic differentiation of stem cells.
LAN Yuanchen, LIN Hengyi, JIANG Yukun, HU Zhiai, ZOU Shujuan
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Engineering of mesenchymal stem cell-derived exosomes and their application progress in the field of oral medicine [PDF]
In recent years, mesenchymal stem cell-derived exosomes (MSC-EXO) have garnered increasing attention in the field of stomatology and have become an established research area in biomedical research. This article reviews the engineering of exosomes derived
ZHAO Yunfeng, LIU Qian, LI Meng, LI Luying, ZHANG Wei, HU Xiantong, MA Chufan
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浙江大学学报. 医学版铁死亡是一种依赖铁代谢失衡并以脂质过氧化为特征的调控性细胞死亡形式，在多种病理过程中发挥关键作用。研究表明，铁死亡的发生与肝细胞癌（HCC）的进展密切相关。铁死亡参与调控HCC的脂质代谢、铁离子稳态、线粒体代谢和氧化还原过程，在HCC肿瘤免疫中发挥着关键作用。铁死亡通过调节免疫微环境中不同细胞的表型和功能影响肿瘤的免疫逃逸和进展；铁死亡诱导的脂质过氧化物和氧化应激能促进M1型巨噬细胞的极化，增强肿瘤的促炎反应，同时抑制髓源性抑制细胞和调节性T细胞等免疫抑制细胞的功能，从而破坏免疫抑制 ...
莫 宇倩, 邹 志霖, 陈 二宝
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Novel Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia [PDF]
, 2016 缺血乏氧是肿瘤微环境的重要特征之一，肿瘤的缺血乏氧不仅促进了肿瘤细胞的侵袭转移，同时还增强肿瘤对化疗药物的耐药性。肿瘤相关巨噬细胞（Tumor-associatedmacrophages，TAMs）浸润在肿瘤微环境之中，通常在肿瘤缺血乏氧区域富集。肿瘤相关巨噬细胞作为肿瘤微环境的重要功能细胞，其在肿瘤细胞的增殖、侵袭、转移、化疗耐药等肿瘤进展的各个阶段均发挥着重要作用。鉴于此，我们提出一种新型的肿瘤治疗策略，以期改变肿瘤微环境的同时，增强实体瘤对化学治疗的疗效 ...
宋曼莉
core
Toxic effects of indium tin oxide nanoparticles on macrophages [PDF]
Objective The toxic effects of indium tin oxide nanoparticles (ITO NPs) on RAW264.7 macrophages, including cell viability, oxidative stress, and inflammatory cytokine release, were studied in order to elucidate the underlying mechanisms of ITO NPs ...
ZHANG Yu
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