Research progress of plant exosome-like nanoparticles on characteristics, components and functions [PDF]
Exosome-like nanoparticles （ELNs） are nano-sized extracellular vesicles enclosed by lipid bilayer membrane and secreted by cells; And carrying a variety of cargo, including lipids, proteins, miRNAs and secondary metabolites.
CHEN Chunping +4 more
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The role of macrophage metabolic reprogramming in myocardial infarction [PDF]
Myocardial infarction (MI) is one of the major cardiovascular diseases that threaten human health and the post-MI inflammation affects its progression and prognosis.
CHENG Xiang, GU Muyang, ZOU Zicong
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Study on the mechanism of trimethylamine oxide damaging cardiac function in mice with hypertrophic cardiomyopathy [PDF]
Objective·To investigate the effects of trimethylamine oxide (TMAO) on cardiac function in mice with hypertrophic cardiomyopathy (HCM) and its potential molecular mechanism.Methods·Mice with myosin heavy chain 6 (Myh6) c.1211G>A (p.R404Q+/-) point ...
CHEN Hanzhang +8 more
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, 2019 【目的】探讨伊马替尼（Ima）在体外对脂多糖（LPS）诱导的RAW264.7巨噬细胞炎症表型的影响。【方法】RAW264.7细胞在LPS（0.1μg/mL）或/和Ima（1μmol/L，5μmol/L）处理后，通过Q-PCR方法检测细胞因子IL-1β、IL-10、CCL2、iNOS、TNF-α和Arg1的mRNA表达变化；采用Western Blot检测iNOS蛋白表达变化以及NF-κB和MAPK信号通路活化情况；利用ELISA法检测细胞上清IL-1β、CCL2、IL-10和TNFα的蛋白表达情况 ...
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大黄素对糖尿病肾病小鼠AMPKα1/TLR4/p65信号通路的影响 [PDF]
, 2019 目的观察大黄素(Emodin)对糖尿病肾病(DN)模型小鼠AMPKα1/TLR4/p65信号通路的影响。方法采用SPF级雄性KK-Ay小鼠,经高脂饲料诱导3周建立DN模型,将30只模型成功KK-Ay小鼠随机分为模型组,阳性药组,大黄素高、中、低剂量组,每组6只,另将6只雄性C57BL/6J小鼠设为正常组,分组后大黄素低剂量组由于操作失误导致1只小鼠死亡。正常组及模型组予去离子水10 ml/(kg·d),阳性药组予缬沙坦13. 33 mg/(kg·d),大黄素各组分别予大黄素13. 33 mg/(kg·d)
卜祥伟 +9 more
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Research progress on the regulation of signal pathways related to lung injury in sepsis by the active components of traditional Chinese medicine [PDF]
Sepsis is a systemic inflammatory response syndrome caused by infection，with resulting organ dysfunction being the key factor in mortality. The lung is one of the organs most frequently affected by sepsis. Recent studies have shown that active components
RONG Jilintai*，SU He，ZHANG Ruifen，ZHANG Hairong，JIA Tingting，GUO Sihan，ZHAO Jian，LI Xiao，ZHONG Xin
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Recent Progress in Understanding the Mechanism of Action of Lactic Acid Bacteria in Promoting Calcium Absorption in the Human Body [PDF]
More and more evidence shows that lactic acid bacteria play an important role in improving calcium absorption and promoting bone health. However, there is a lack of systematic research on the mechanism by which lactic acid bacteria promote calcium ...
MA Zhihe, WANG Ruixue, WANG Junguo
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旋毛虫排泄分泌抗原53-ku重组蛋白上调M2型肺泡巨噬细胞减轻脓毒症小鼠急性肺损伤
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨重组旋毛虫排泄分泌抗原53-ku蛋白（rTsP53）对小鼠急性肺损伤的保护作用及其机制。【方法】采 用尾静脉脂多糖注射（LPS，10 mg/kg）建立BALB/c小鼠急性肺损伤模型。在肺损伤后2 h尾静脉注射rTsP53（50 μg/只）治 疗。统计各组小鼠72 h累计死亡率，HE染色法观察各组小鼠肺脏病理损伤情况，测量肺脏湿/干质量比（W/D），ELISA法检 测各组小鼠肺泡灌洗液 IL-6 和 IL-4 浓度，RT-PCR 法检测各组小鼠肺泡灌洗巨噬细胞 TNF-α、iNOS、IL-
关开泮 +3 more
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Significant fundamental translational research on breast cancer in China: progress and prospects [PDF]
Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through
LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin
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Zhongshan Daxue xuebao. Yixue kexue ban口腔白斑病是一种发病率高的潜在恶性黏膜疾患，巨噬细胞在口腔白斑病恶性转化中发挥重要调控作用，但该过程的分子机制研究存在不足。近年研究发现巨噬细胞M2极化对口腔白斑恶性转化具有显著影响，且该过程受到免疫细胞、微生物、细胞因子、细胞外基质等一系列复杂的网络调控。因此本文就巨噬细胞在口腔白斑中的生物学功能、亚型以及其极化的调控因素进行综述，并结合课题组在口腔胞内定植菌与黏膜恶性肿瘤关系的前期研究基础，提出口腔胞内定植菌如牙龈卟啉单胞菌等可能通过促进巨噬细胞M2极化诱导免疫抑制微环境并最终促进白斑恶性转化的机制，
贾益群, 郑雨燕
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