重症脑梗死患者血清中miR-206和miR-210的表达变化及临床意义
Zhongguo shiyan zhenduanxue目的 探究重症脑梗死患者血清中微小RNA-206(miR-206)和微小RNA-210(miR-210)的表达变化及临床意义。方法 选取2021年6月至2022年6月在黄河三门峡医院收治的重症急性脑梗死(ACI)患者96例为重症ACI组，同期收集治疗的轻型ACI患者90例为轻型ACI组，体检健康的志愿者94例为对照组。采用实时荧光定量PCR(qRT-PCR)法检测各组血清miR-206和miR-210的表达水平；采用Pearson法分析重症ACI患者血清miR-206和miR-210表达的相关性 ...
郭发瑞 +4 more
doaj
Zhongguo shiyan zhenduanxue, 2015 目的探讨miR-514在肾细胞癌中的表达变化及其临床意义。方法提取45例肾癌及其癌旁正常组织中的总RNA,逆转录后用实时荧光定量PCR的方法检测miR-514在肾癌组织和癌旁正常组织中的表达情况,并分析其与肾癌患者临床病理特征的关系。结果与相应癌旁组织相比,miR-514在肾癌组织中表达量显著下调,下调率为86.67%。miR-514表达水平与患者年龄、性别、病理分型、TNM分期没有关系,但其表达水平与Fuhrman分级有关。结论 miR-514可能与肾癌的发生发展有密切关系,进行miR ...
杨媛慧 +3 more
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[Characteristics and microRNA expression profile of exosomes derived from odontogenic dental pulp stem cells]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2023 Ye YY, Yue L, Zou XY, Wang XY.
europepmc +1 more source
The screening of miRNAs involved in WSSV infection and the role of Drosha in shrimp against WSSV [PDF]
, 2010 对虾白斑综合症病毒（WhiteSpotSyndromicVirus，WSSV），是一种严重危害对虾养殖业的主要病原，目前还未找到有效的防治办法。microRNA（miRNA）是真核生物中一类长度约21个碱基并具有调控基因表达作用的非编码小RNA。研究表明miRNA在发育、免疫等过程中发挥重要作用，但与病毒感染相关的miRNA研究目前很少。因此，本论文筛选和分析对虾中与WSSV感染相关的miRNA，揭示与病毒感染相关的miRNA，同时为对虾病害防治提供依据 ...
徐丹丹
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[Effects of collagen type ⅩⅦ α1 on epidermal stem cells in aging skin and the microRNA intervention mechanism]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 2022 Sun JC +5 more
europepmc +1 more source
The value of exosomes suppressor of cytokine signaling 1， speckled protein 140 and calcyclin binding protein expressions in peritoneal dialysis effluent in the diagnosis of peritoneal fibrosis [PDF]
ObjectiveTo investigate the value of suppressor of cytokine signaling 1 （SOCS1）， speckled protein 140 （SP140）， calcyclin binding protein （CacyBP） expressions in peritoneal dialysis effluent in the diagnosis of peritoneal fibrosis （PF）.MethodsA total of ...
Cao Yan-chun +7 more
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Zhongguo shiyan zhenduanxue, 2016 目的探讨肾癌中miR-122的表达特点及临床意义。方法基于前期平行测序的工作基础,对51例肾癌及相应癌旁组织、15例肾癌患者血清及15例健康对照者血清中miR-122的表达水平进行RT-qPCR检测,分析miR-122的表达高低与肾癌患者临床病理特征之间的相关性;并通过在肾癌细胞系（786-O和ACHN）中转染miR-122inhibitors,观察转染后细胞的增殖改变,初步探讨miR-122的生物学功能。结果相对于癌旁组织,肾癌组织中miR-122表达水平明显升高,上调率为82.35 ...
曹拓, 赵春娟, 余振东
doaj
[Expression and effect of microRNA-627 in human hypertrophic scar]. [PDF]
Zhonghua Shao Shang Za Zhi, 2021 Guo BY, Lin F, Hui Q, Wang HY.
europepmc +1 more source
A preliminary study on the colocalization of miR-574-5p with TLR7/8 in cells and the effects of inhibition of miR-574-5p-TLR7/8 signaling on lupus and lupus nephritis in a line of lupus-prone mice [PDF]
, 2017 MicroRNA(miRNA)是一种小型的非编码RNA，可以识别信使RNA的3’端非编码区进而可使得信使RNA降解抑制其翻译，调控基因的表达。有研究揭示了miRNA非传统性功能，可以与内源性的单链RNA竞争与Toll样受体结合。还有研究表明，在癌症细胞中，miR-21和miR-29a可以与小鼠mTlr7/人hTLR8结合，激活TLR信号通路促进炎症反应。然而，miRNA在自身免疫性疾病中的功能目前还知之甚少。B6.MRL-Faslpr/J小鼠是研究SLE的重要小鼠模型，伴随有自身抗体的产生 ...
张艳
core
Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis [PDF]
Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes,
FAN Zhisong, FENG Li, ZHANG Zongwen
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