Results 51 to 60 of about 6,484 (105)
Zhongguo shiyan zhenduanxue, 2018 微小RNA(miRNA)是内源性非编码的小分子RNA的一个种类,大约只有18-25个bp的长度。在动物基因组中,它大多以单拷贝、多拷贝或基因簇等形式广泛存在着。它虽然只是占人类基因组的约1%的内容,但是人类将近三成的基因却受其调节。它不但可作为癌基因存在,也可以作为抑癌基因而起到作用。在Mitchell等人[1]的研究中已证明外周血血浆中存在稳定的miRNA。miR ...
王先伟, 陈东, 李召磊
doaj
Zhongguo shiyan zhenduanxue, 2009 目的分析局部注射和肝动脉给予血管抑素基因（Angiostatin）和内皮抑素基因（Endostatin）重组质粒对大鼠肝癌治疗效果的差异。方法将肝癌模型大鼠随机分为:局部治疗组、局部对照组、肝动脉治疗组、肝动脉对照组。治疗组给予200μL质粒和脂质体复合物和对照组给予生理盐水200μL。治疗后观测肿瘤大小、微血管密度、血管内皮生长因子、肿瘤凋亡指标的变化。结果6d开始基因治疗组各治疗指标与对照组相比均具有统计学差异 ...
谢耀萍, 杨志杰, 李勇, 马铎
doaj
Zhongguo shiyan zhenduanxue, 2008 目的研究三氧化二砷在体外杀伤人卵巢癌细胞SKOV3的机理。方法运用ELISA法检测SKOV3细胞中,VEGF基因的表达情况。结果经三氧化二砷处理后人卵巢癌细胞SKOV3中,VEGF基因表达减弱。结论三氧化二砷可能是通过下调VEGF基因的表达,来抑制SKOV3肿瘤细胞的增殖和转移。
何凯 +5 more
doaj
Zhongguo shiyan zhenduanxue, 2007 目的本研究旨在探讨E1A基因对乳腺癌细胞凋亡的影响,为乳腺癌E1A基因治疗的可行性提供理论和实验依据。方法①构建E1A基因真核表达质粒pEGFP-E1A:通过酶切反应获得E1A基因,琼脂糖凝胶回收后,连接入pEGFP-C1载体EcoRⅠ和BamHⅠ位点中。②E1A基因转染乳腺癌细胞系:脂质体介导将E1A基因转入乳腺癌细胞系SK-BR-3细胞株,经筛选获得稳定表达E1A基因的转染试验组细胞。③RT-PCR检测E1A基因的mRNA表达、west-ern-blot检测E1A蛋白表达。流式细胞仪观察细胞凋亡率 ...
杨新宇 +3 more
doaj
O-GlcNAcylated YTHDF2 promotes bladder cancer progression by regulating the tumor suppressor gene <i>PER1</i> via m<sup>6</sup>A modification. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanWang L +5 more
europepmc +1 more source
[Advances in basic and experimental diagnostic research on liver diseases in 2025]. [PDF]
Zhonghua Gan Zang Bing Za ZhiChen DB, Yang RF, Chen HS.
europepmc +1 more source
[Heterogeneity of tumor-associated macrophages and precision targeting strategies in hepatocellular carcinoma]. [PDF]
Zhonghua Gan Zang Bing Za ZhiHuang K, Zhang GQ.
europepmc +1 more source
[Quercetin inhibits proliferation and migration and promotes apoptosis of gastric cancer cells by promoting phosphorylation-mediated YAP inactivation]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoWang Y +8 more
europepmc +1 more source
[Research progress in liver cancer in 2025]. [PDF]
Zhonghua Gan Zang Bing Za ZhiMiao TG, Nan YM.
europepmc +1 more source
[<i>Yiqi Jiedu</i> Formula inhibits proliferation, invasion and migration of nasopharyngeal carcinoma cells by inhibiting the AKT1/GLUT1 signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoXu H +8 more
europepmc +1 more source