Results 31 to 40 of about 2,351,627 (156)
Zhongguo shiyan zhenduanxue, 2010 目的了解来源于不同临床标本的肺炎克雷伯菌的耐药性、携带第1类耐药整合子的特征及基因盒的种类。方法使用常规方法分离肺炎克雷伯菌;运用法国梅里埃VITEK细菌分析系统进行鉴定;应用PCR法扩增第1类整合子;应用纸片扩散法对22种抗生素进行耐药性监测和分析。结果20191株产ESBLs肺炎克雷伯菌中检测出Ⅰ类整合子178株,检出率为93.2%,Ⅰ类整合子阳性菌对氨基糖苷类、喹诺酮类及头孢菌素类药物表现出较高的耐药,其多重耐药率明显高于Ⅰ类整合子阴性菌株。结论Ⅰ类整合子广泛地存在产ESBLs肺炎克雷伯菌中 ...
郭红阳, 朱光泽, 连树林
doaj
Rare Metals, Volume 45, Issue 8, August 2026.ABSTRACT Advanced metallic glasses, leveraging their ultrahigh strength, excellent corrosion resistance, superior soft magnetic properties and good biocompatibility, have gradually become indispensable strategic cornerstones in critical fields such as aerospace, electronic information and energy power. This unique combination of properties enables them
Yizhou Liu +11 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2016 目的检测多重耐药的铜绿假单胞菌中整合子系统的分布和耐药基因携带情况,并探讨整合子系统的分布与多重耐药的关系。方法选取2012年5月至2012年10月由大连医科大学附属第一医院住院患者各种标本中分离的多重耐药的铜绿假单胞菌148株,提取全基因组DNA,通过PCR方法扩增Ⅰ、Ⅱ、Ⅲ类整合子和相关耐药基因bla CTX-M、bla SHV、bla VIM、bla IMP、OPrD2、aadA、aadB,并通过凝胶电泳方法对扩增结果进行分析。结果在多重耐药的铜绿假单胞菌中I类整合子阳性检出率为56.1%（83 ...
肖晓光, 李艳莲, 孙国华
doaj
Rare Metals, Volume 45, Issue 8, August 2026.ABSTRACT Infected bone defects represent a dual therapeutic challenge demanding concurrent infection inhibition and osteogenesis promotion. Systemic antibiotic administration is taken as a classical treatment protocol but often yields inadequate local antibiotic concentrations and delayed bone repair.
Xucai Wang +8 more
wiley +1 more source
, 2013 整合素是重要细胞表面受体。表达于白细胞表面的β2整合素通过其头部I domain与血管内皮细胞表面的配体ICAM-1结合,在炎症反应中起关键作用。作为介导细胞内外双向信号转导的分子,整合素inside-out信号转导及激活通路已被广泛认同,而outside-in变构路径却遭遇到严峻挑战:1)由外向内激活第一步,低亲和态整合素能否结合外源性配体,而由外向内激活是否依赖于外源性配体结合?相应结构基础不清楚;2)对于含I ...
毛德斌 +4 more
core +2 more sources
Gaoya dianqi, 2008 介绍了特高压交流架空线路用1 000 kV棒形悬式复合绝缘子电场分布计算及均压特性研究等情况,运用三维有限元法,比较了整体单支、1/3和2/3元件组串、1/6和5/6元件组串和一种1/6瓷质绝缘子及5/6复合绝缘子组串,结果可以看出,两复合绝缘子元件组串对电场分布没有任何改善,在结构上复合绝缘子采用整体单支比两元件组串的好;导线侧使用瓷质绝缘子,接地侧使用复合绝缘子组串,可以充分利用瓷质绝缘子良好的耐电弧性和复合绝缘子良好的憎水防污性,比采用整体单支复合绝缘子的电场分布均匀 ...
孙西昌 +4 more
doaj
Gaoya dianqi, 2023 近年来GIL三支柱绝缘子故障频发，暴露出GIL设备在国产化设计、制造、应用进程中仍存在改进空间，早期投运的因结构设计、制造工艺不合理而存在隐患的GIL设备亟待整改。文中对“两渡”直流输电工程发生的几起GIL三支柱绝缘子典型故障案例及解体情况进行了分析，结合GIL结构设计、生产、装配和质检工艺对该批次GIL设备的故障原因及隐患进行了总结。最后提出了通过优化三支柱绝缘子生产及检验工艺、优化固定及活动三支柱绝缘子在导杆上的装配工艺、优化固定三支柱绝缘子粒子捕捉器装配工艺 ...
王典浪 +4 more
doaj
Metal‐Based Materials for Redox Modulation in Biomedicine
Rare Metals, Volume 45, Issue 8, August 2026.ABSTRACT Metal materials have become increasingly important in modulating biological redox networks for therapeutic and diagnostic purposes, owing to their distinctive electronic properties and adaptable reactivity. This review synthesizes recent developments across various metal‐based materials, including elemental metals, metal oxides, coordination ...
Yan Fan +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2009 目的为鉴定伤寒沙门菌的耐药性获得与整合子之间的关系,确定该菌抗性基因扩散的可能机制。方法我们选取32株多药耐药的伤寒沙门菌株提取全基因组DNA,扩增整合子,并以此作为模板检测抗性基因。结果以伤寒沙门菌基因组DNA为模板有81.2%的菌株,能够扩增出相应整合子的目的片段。具有四环素抗性、氨苄青霉素抗性和复方磺胺抗性的样品,以其扩增产物作为模板全部能扩增出相应抗性基因suⅡ、blaTEM-1和tetG。结论伤寒沙门菌的抗性基因是整合在Ⅰ类整合子中的,故整合子的转移应是伤寒沙门菌抗性基因传递的一种主要途径。
黄海, 李军, 黄健, 陶建蜀
doaj
Multimodal Deep Learning‐Assisted Microstructural Evaluation System for Sintered NdFeB Magnets
Rare Metals, Volume 45, Issue 8, August 2026.ABSTRACT The performance of sintered NdFeB magnets, especially coercivity, is critically determined by their complex microstructure. However, a quantitative microstructural evaluation system (MES) is much needed but has long been missing in the community.
Zihao Wang +8 more
wiley +1 more source