[Photobiomodulation Promotes Hippocampal Neurogenesis and Improves Cognitive Function and Anti-Inflammatory Injury in Rats With Chronic Cerebral Hypoperfusion]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 目的 探讨光生物调节（photobiomodulation, PBM）对脑慢性低灌注大鼠海马神经元再生及认知功能和炎症损伤的影响。 方法 将雌性SD大鼠去双侧卵巢，1周后随机分为假手术组（Sham）、BCCAO组、PBM干预组（BCCAO+PBM），每组8只。BCCAO组永久性结扎大鼠双侧颈总动脉（bilateral common carotid artery occlusion, BCCAO）建立脑慢性低灌注模型，但不予光照；Sham组只钝性分离左、右侧颈总动脉，但不结扎，不予光照。BCCAO ...
Tu J, Huang Y, Huang Y, Wu M, Wang R.
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海马神经元和神经递质的衰老性变化及自由基分析——探讨老年性记忆减退的神经基础 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 1988 用形态计量、显微光学测定,放射自显影和ESR分析等方法研究揭示,衰老时海马神经元的RNA、核仁体积、衰老色素(LP)和谷氨酸(Glu)递质等发生了明显的改变;海马自由基含量显著高于其他脑区。本文就自由基损害与海马衰老的易感性,神经元损害间的联系及其与老年性记忆减退的关系进行了讨论。
姚志彬
doaj +2 more sources
氧化应激在阿尔茨海默病病理发生中的作用机制与干预策略 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 阿尔茨海默病（AD）是常见的神经变性病，氧化应激在AD 早期病理发生和发展中起到了重要的作用。在老化、早老素 1（PS1）突变及环境等共同作用下，脑内出现过度氧化应激，促进β-淀粉样蛋白（Aβ）的形成，Aβ可能为氧化应激作用下的适应性产物。氧自由基产生与清除的失衡还可导致海马神经元自噬功能异常，诱导细胞从自噬到死亡，其可能的机制是Notch1 通路失调。Notch1 通路的失调导致机体抗氧化应激能力丧失和淀粉样前体蛋白（APP）剪切增多、Aβ沉积，最终引起AD 病理的发生与发展 ...
刘军
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Research progress on the relationship between axonal transport dysfunction in neuronal cells and Alzheimer’s disease [PDF]
, 2022 Alzheimer’s disease is known as one of the “top ten killers in the world”. Due to lack of effective therapy at present， early pathological changes have captivated widespread attention.
Yu Minghui, Xue Ao, Xu Hongdan, Wang Yan, Lin Xue, Yang Bo, Sun Huifeng, Zhang Ning
core +1 more source
Advances in the Study of Natural Product Polysaccharides for the Relief of Depression and Their Mechanisms [PDF]
, 2023 Depression, as a common mental disorder, is often alleviated and treated with antipsychotic drugs in clinical practice. However, long-term use of such drugs can lead to serious sequelae such as drowsiness, nausea and memory loss in patients.
Yuhe BAI
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Change of transcription factor EB activity and autophagy in hippocampus of type 2 diabetic encephalopathy mice [PDF]
, 2023 Objective·To investigate the changes of transcription factor EB (TFEB), the activity of the upstream proteins and autophagy in the hippocampus of mice with type 2 diabetic encephalopathy.Methods·Twenty healthy 8-week-old male C57BL/6J mice were randomly ...
CHEN Yixin +3 more
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Aβ1-42诱导的小胶质细胞炎性反应对神经元细胞Mecp2蛋白表达的影响 [PDF]
, 2018 目的:体外研究Aβ1-42诱导的小胶质细胞炎症反应对海马神经元细胞甲基化Cp G结合蛋白（Mecp2）表达的影响。方法:（1）用不同浓度的Aβ1-42（终浓度分别为0,5,10,20,30μmol/L）处理小胶质细胞系（N9）,24h后取上清液,ELISA检测每组N9细胞培养上清中炎症因子TNF-α、IL-1β的含量,选择合适的Aβ1-42的终浓度。（2）用Aβ1-42（终浓度为20μmol/L）及TLR4拮抗剂TAK-242（终浓度为1μg/ml）处理小胶质细胞系（N9）,分为3组:正常对照组 ...
喻倩 +8 more
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Alzheimer disease : subcellular Aβ mechanisms and treatment strategies [PDF]
, 2023 The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms in neurons at the subcellular
Gao, Yang
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Latest Research on the Neuroprotective Mechanism of Short-chain Fatty Acids in Stroke and Its Relation with Post-stroke Cognitive Impairment [PDF]
, 2022 Post-stroke cognitive impairment is one of the common complications of stroke, seriously affecting patients' ability to perform activities of daily living.
LIU Huanhuan, LI Ruiqing, SU Kaiqi, YUAN Jie, LI Qi, FENG Xiaodong
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高脂饮食诱导
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探讨高脂饮食引起的慢性炎症反应与阿尔兹海默病神经功能障碍之间的关系。方法12月龄C57BL/6J小鼠和APPswe/PS1ΔE9（APP/PS1）雄性小鼠，按体质量随机分为4组，正常组（C57BL/6J小鼠n=6）、普通高脂组（C57BL/6J小鼠+高脂饲料n=6）、痴呆组（APP/PS1小鼠n=6）、痴呆高脂组（APP/PS1小鼠+高脂饲料n=6）4组；普通饲料/高脂饲料喂养6周。每周监测小鼠体质量变化，免疫组化观察海马小胶质细胞激活情况，RT-qPCR检测海马炎性因子IL-1β、IL-6、TNF-
李泽 +6 more
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