应用改进的大鼠应激模型证实海马CA3区神经元Nestin?NPY表达变化
【目的】 应用改良的连续?恒定复合型应激大鼠模型,观察其血浆肾素活性(PRA)?血管紧张素Ⅱ(AngⅡ)水平和海马CA3区的Nestin?NPY表达? 【方法】 将雌性成鼠束缚并倒悬应激6 h/d,用放射免疫法测定急性应激(3 d)后血浆PRA?AngⅡ水平,用免疫组织化学方法观察应激3 d?21 d后CA3区锥体层细胞的Nestin?NPY表达变化?
doaj
[Role and Mechanism of High Mobility Group Box 1 in Mediating Depression-Like Behaviors in Mice via Regulation of the 5-Hydroxytryptamine Receptor 7 Signaling Pathway]. [PDF]
DU O, Duan S, Tang L, DU J.
europepmc +1 more source
SB202190对卡英酸诱导的癫痫大鼠模型认知功能的影响及机制
摘 要:【目的】 研究p38丝裂原活化蛋白激酶(p38MAPK)选择性抑制剂SB202190对卡英酸(KA)致痫大鼠学习、记忆能力的影响及其与海马神经元凋亡的关系的探讨。【方法】40只大鼠随机分为4组:假处理组、模型组和SB202190低、高剂量组(剂量分别为7.5 mg/kg,30 mg/kg),对各组大鼠进行行为学观察,应用Morris水迷宫试验,检测大鼠学习和记忆能力,同时通过BL-420F生物机能实验系统描记脑电图的变化,采用 TUNEL 检测细胞凋亡并计算凋亡率 ...
doaj
[Esketamine alleviates depression-like behaviors in mice with chronic restraint stress by activating glutamatergic neurons in the medial prefrontal cortex]. [PDF]
Zhang Z +7 more
europepmc +1 more source
[Role of dysregulation brain lipid metabolism in depression]. [PDF]
Yu P, Huang S, Jiang Z, Wang X, Jiang D.
europepmc +1 more source
[Formononetin downregulates P53/SAT1/ACSL4 pathway-mediated ferroptosis to improve hypoxic-ischemic brain injury in neonatal mice]. [PDF]
Guo T +8 more
europepmc +1 more source
[Toxicity of dibutyl phthalate in primary cultured rat hippocampal neurons and the toxicological mechanism]. [PDF]
Li Y +6 more
europepmc +1 more source
[<i>Qingre Lidan Jiedu</i> Recipe improves high copper load-induced cognitive dysfunction in rats by regulating mitophagy]. [PDF]
Wang Y +6 more
europepmc +1 more source
[Progresses on temporal interference electromagnetic stimulation for non-invasive deep brain function modulation]. [PDF]
Zhou T, Yu P, Xu Y.
europepmc +1 more source
[Neuroprotective effects of idebenone combined with borneol via the dopamine signaling pathway in a transgenic zebrafish model of Parkinson's disease]. [PDF]
Wang Q +5 more
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