Results 41 to 50 of about 1,642 (164)
Effects of Dendrobium nobile Lindl. alkaloids on behavior and hippocampal tissue damage in manganese-exposed rats [PDF]
BackgroundManganese is an essential trace element for the human body and maintains normal development of many organs including the brain. However, long-term exposure to a high manganese environment or excessive manganese intake will lead to manganese ...
Jida LI +8 more
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神经保护肽重组慢病毒对老年痴呆大鼠行为学及海马结构内NF-kBmRNA表达的影响
Zhongguo shiyan zhenduanxue, 2008 目的探讨神经保护肽慢病毒（rLent/NT4-NAP）感染老年痴呆大鼠鼻粘膜后分泌的NAP对老年性痴呆（AD）大鼠行为学及海马内NF-kBmRNA表达的影响。方法选择无菌级雄性Wister大鼠40只,随机分为对照组,假手术组,AD组,rLent/NT4-NAP组,每组10只。建立β-淀粉样蛋白（Aβ）大鼠海马注射的实验性AD大鼠动物模型[2],利用水迷宫试验检测大鼠记忆能力,利用原位杂交的方法观察大鼠海马内NF-kBmRNA的表达。结果与AD组相比,rLent/NT4 ...
白晶, 杨弋, 杨薇, 吴江
doaj
Zhongshan Daxue xuebao. Yixue kexue ban, 2005 【目的】探讨早期和延迟高压氧(HBO)治疗对缺氧缺血性脑损伤(HIBD)新生大鼠的远期影响。【方法】7日龄大鼠37只随机分为对照组(n=10，假手术处理)、HIBD组(n=9)、EHBO组(n=9，HIBD模型后0.5～1h开始2个绝对大气压HBO治疗，稳压30min／次，间隔24h，连续2次)和LHBO组(n=9，HIBD模型后48～72h开始2个绝对大气压HBO治疗，稳压30min／次，间隔24h，连续5次)，以大鼠远期的学习记忆功能(Morris水迷宫实验)和海马形态组织学 ...
刘美娜
doaj
Research Progress on Biological Activity and Application of Lycium barbarum Polysaccharide [PDF]
Lycium barbarum is a traditional Chinese medicinal material with a long history of homology of medicine and food. Lycium barbarum polysaccharide is a natural plant polysaccharide isolated from Lycium barbarum fruit, which is one of the key bioactive ...
Aoyi DUAN +4 more
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EPO对心肺复苏后大鼠海马神经元的细胞凋亡、Bcl-2及Bax表达的影响
Zhongguo shiyan zhenduanxue, 2012 目的观察促红细胞生成素（EPO）在心肺复苏后对大鼠脑海马神经元细胞凋亡、Bcl-2和Bax表达的影响。方法雄性Wistar大鼠32只,随机分4组:正常对照组（A组）、假手术组（B组）、心肺复苏模型组（C组）、EPO干预组（D组）。C组、D组采用窒息的方法制作大鼠呼吸心跳骤停模型,后行心肺复苏治疗（CPR）,D组CRP同时静脉给予EPO 3000U/kg;B组仅静脉给予等剂量生理盐水,4小时的脑海马组织,采用免疫组化法观察各组神经元细胞凋亡、Bcl-2及Bax的表达情况。结果光镜下A、B组未见凋亡细胞 ...
孙晓佳 +4 more
doaj
柴郁地仙方对围绝经期抑郁症模型大鼠行为学及海马BDNF、TrkB蛋白表达的影响 [PDF]
, 2018 目的观察柴郁地仙方对围绝经期抑郁症(perimenopausal depressive disorder, PDD)模型大鼠行为学及海马脑源性神经营养因子(brain derived neurotrophic factor, BDNF)、酪氨酸激酶B受体(tropomyosin receptor kinase B, TrkB)蛋白表达的影响,探讨其抗围绝经期抑郁症的作用机制。方法 48只3～4月龄雌性SD大鼠随机分为假手术组、模型组、阳性对照组、柴郁地仙方低、中、高剂量组,共6组,每组8只 ...
周静 +6 more
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Effects of deltamethrin subchronic exposure on inducing hepatic lipid metabolism disorder in mice [PDF]
Objective To investigate the effects of deltamethrin (DM) subchronic exposure on hepatic lipid metabolism in male mice. Methods Eighteen specific pathogen-free (SPF) male C57BL/6J mice (8-week-old) were randomly assigned to a control group (pure corn oil)
Minjia WU +6 more
core +1 more source
, 2019 蛋白磷酸酶2A(PP2A)是真核细胞内广泛表达的丝/苏氨酸蛋白磷酸酶家族成员之一,通过去磷酸化作用参与外源物诱导细胞毒性损伤和致癌过程中关键调控蛋白的可逆磷酸化,进而抑制绝大多数丝/苏氨酸激酶的活性。近年来,PP2A在线粒体质量控制(MQC)中的作用逐渐被认识,广泛参与线粒体生物发生、线粒体动态、线粒体氧化还原平衡和线粒体自噬等重要生物学过程,对拓展MQC相关蛋白翻译后修饰在以线粒体为核心枢纽的信号流中的研究具有重要意义。本文重点阐述PP2A介导的去磷酸化机制在MQC调控中的作用 ...
林忠宁, 林育纯, 车琳
core
Research progress of affective touch intervention on early life stress-related anxiety disorders [PDF]
Anxiety disorders are characterized by persistent and excessive fear, anxiety and concern, accompanied by avoidance behaviors and physical symptoms such as increased heart rate, shortness of breath and muscle tension, which is one of the most prevalent ...
LIAO Bingbing, WANG Zhen
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[The TXNIP/Trx-1/GPX4 pathway promotes ferroptosis in hippocampal neurons after hypoxia-ischemia in neonatal rats]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2022 Zhang XY +6 more
europepmc +1 more source