Results 51 to 60 of about 1,642 (164)
Zhongguo shiyan zhenduanxue, 2017 目的探讨Src激酶抑制剂PP2在大鼠脑缺血再灌注后对神经元延迟性死亡保护作用的机制。方法建立Wistar大鼠全脑缺血再灌注动物模型,分为无缺血再灌注正常空白对照组（sham）,Src激酶抑制剂PP2实验组（PP2）和Src激酶抑制剂PP2类似物的实验对照组（PP3）。实验组及实验对照组Wistar大鼠在双侧颈动脉夹闭造成全脑缺血前30分钟于脑室内分别注射PP2和PP3,控制大鼠脑组织缺血时间均为10min,再灌注时间均为72h。于再灌注时取出大鼠脑组织 ...
刘桂锋, 韩亮, 赵景伟
doaj
Advances in the Structure, Separation, Bioactivities and Applications of Probiotic Extracellular Vesicles [PDF]
Extracellular vesicles (EVs), emerging as a novel category of postbiotics, possess various bioactive functions. Probiotic-derived EVs are nanoscale lipid bilayer particles secreted by probiotics into the extracellular matrix, which cannot self-replicate.
ZHONG Hao, TANG Ning, LIU Xiaofeng, CHEN Ling, GUAN Rongfa
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[Effects of CACNA1H gene knockout on autistic-like behaviors and the morphology of hippocampal neurons in mice]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2022 Jiao C, Wang JM, Kuang HX, Wu ZH, Liu T.
europepmc +1 more source
低剂量电离辐射对Ⅰ型糖尿病大鼠海马神经元细胞凋亡和氧化损伤的影响
Zhongguo shiyan zhenduanxue, 2019 目的探讨低剂量电离辐射(LDR)对Ⅰ型糖尿病模型大鼠海马神经元细胞凋亡和氧化损伤的影响,阐明二者的关系。方法利用链尿佐菌素(STZ)建立Wistar大鼠糖尿病模型(DM)后,造模完成后分为正常组、模型组、模型+25mGy、模型+50mGy和模型+75mGy组,每组20只。给予25、50和75mGy隔日照射,共计12次,继续饲养4周后麻醉后处死大鼠,取出海马组织利用生化法检测海马中丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的活力;并利用流式细胞术检测细胞凋亡和活性氧(ROS)含量 ...
刘飞, 郭伟, 王志成
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[The Role of Nrf2 Pathway Activation in Hippocampal Neuron Injury of Neonatal Rats with Bilirubin Encephalopathy]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2021 Liu LB, Tang LX, Lin XZ, Li YD.
europepmc +1 more source
Zhongguo shiyan zhenduanxue, 2008 目的观察老龄小鼠寰枢椎肌肉、韧带、筋膜损伤对其脑衰老进程的影响。方法利用手术损伤小鼠寰枢椎周围软组织。利用跳台试验检测小鼠学习、记忆能力;组织切片HE染色观察脑海马神经元数量;免疫组织化学染色观察β-淀粉样多肽（Aβ）、caspase-3的表达;试剂盒检测血清NO及脑组织SOD、MDA的变化。结果与对照组相比,跳台试验:模型组小鼠反应期明显延长,潜伏期明显缩短,错误次数显著增加 ...
赵洪艳 +4 more
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Zhongguo shiyan zhenduanxue, 2016 边缘叶脑炎是指累及海马、杏仁核、岛叶及扣带回皮质等边缘结构,以急性或亚急性起病,临床表现以近记忆力缺失、精神行为异常以及癫痫发作为特点的中枢神经系统炎症,最初认为此类病变为肿瘤相关性疾病,近年来新型边缘叶脑炎备受关注,如神经元表面抗体相关性边缘叶脑炎,亦称为神经元表面抗体综合征（NSES）[1],由于人们对此类脑炎认识不足,早期易误诊,延误诊治,对其预后造成不良影响,现将我院收治的1例"难治性癫痫 ...
于晓赟 +5 more
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Effects of curcumin on anti-proliferation and expression of apoptosis interrelated gene of Human Osteosarcoma MG-63 Cells [PDF]
, 2009 目的:探讨姜黄素对人成骨肉瘤Mg-63细胞增殖抑制及凋亡相关基因表达的影响。方法:用姜黄素处理Mg-63细胞,细胞计数法检测细胞增殖抑制的效果;荧光染色观察细胞的凋亡;流式细胞仪(fCM)进行细胞周期时相分析;免疫细胞化学法和WESTErn blOTTIng免疫法检测细胞凋亡相关基因的表达水平。结果:随着姜黄素浓度的增加及其作用时间延长,对细胞的增殖抑制作用增强,最高抑制率可达89.07%;光镜下可观察到细胞发生染色质浓缩,细胞核凝聚和碎裂等典型的凋亡形态学改变 ...
刘用金 +5 more
core
The effect of TrkA signaling pathway on the expressions of TRPC1，TRPC3 in 6-hydroxydopamine lesioned rat treated by electroacupuncture [PDF]
Objective: We investigate the effect of TrkA signaling pathway on the expressions of transient receptor potential channel in 6-hydroxydopamine(6-OHDA) lesioned rat treated by electroacupuncture and to explore the role of trkA signaling pathway and TRP ...
Chi, Xiang-lin +2 more
core +2 more sources
组胺H3受体拮抗剂对缺血缺氧性脑病新生大鼠神经保护作用及其机制研究
Zhongguo shiyan zhenduanxue, 2011 目的探讨组胺H3受体拮抗剂硫丙咪胺对缺血缺氧性脑病新生大鼠的保护作用及其机制。方法将生后7天Wistar大鼠分为正常对照组、缺血缺氧脑病（HIE）模型组、治疗组;HIE模型组和治疗组应用左侧颈动脉结扎后缺氧方法制备HIE大鼠,治疗组进一步分为H3治疗组、H3+H1治疗组和H3+H2治疗组。H3治疗组给予5 mg/kg Thio腹腔注射;H2组先给予Dhp 5 mg/kgip,30 min后ip Thio 5 mg/kg;H1组先给予Cim100 mg/kgip,30 min后ip Thio 5 mg ...
贾飞勇 +5 more
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