Results 51 to 60 of about 4,515 (163)
High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural medicinal plants [PDF]
, 2016 酶是治疗多种疾病的重要靶标，乙酰胆碱酯酶（AChE）的抑制剂是现阶段治疗阿尔兹海默症（AD）最有效的一类药物。从天然产物中寻找适宜患者长期服用、毒副作用小、作用面广等优点的乙酰胆碱酯酶抑制剂（AChEIs）受到了科研工作者的广泛关注。本论文以AChE作为药物靶标，构建基于高效液相色谱-质谱联用技术（HPLC-MS）的在线生物活性检测方法，发展集分离纯化、结构确证和活性筛选于一体的活性导向天然产物研究方法，用来寻找和发现天然药用植物中潜在的AChEIs候选化合物 ...
刘静兰
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Integrative Conservation, Volume 4, Issue 3, Page 476-490, September 2025.The leaf functional traits of angiosperms and gymnosperms in mountain ecosystems significantly influence phyllosphere fungal diversity. These traits are critical for understanding fungal stress resistance and elevational adaptation, which aids in predicting plant responses to climate change.
Xiaocheng Yu +7 more
wiley +1 more source
Mindin is up-regulated during colitis and enhances inflammation by activating the transcription activity of NF-κB protein family [PDF]
, 2015 炎症性肠病（IBD）的发生，被认为是遗传、环境和黏膜免疫三方面因素共同作用的结果,而肠黏膜异常的免疫应答又是发病的关键因素之一。在炎症局部，炎性细胞的招募和激活依赖各种细胞膜受体及整合素与细胞基质（ECM）间的相互作用。细胞外基质蛋白Mindin是Mindin/F-spondin家族成员，在小鼠炎症模型中，有多项研究表明Mindin在免疫应答过程中扮演重要角色，但对于其在炎症中的功能和调控机制研究较少。故本课题拟探索肠炎中Mindin的表达水平及其在炎症中的信号调控机制。 本课题研究中 ...
李萍
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Wildlife Letters, Volume 3, Issue 2, Page 73-83, June 2025.Blue sheep in Dhorpatan Hunting Reserve prefer alpine grasslands at 3800–4200 m on south‐facing slopes near water resources, favoring areas with low tree cover and dense ground cover, particularly rhododendrons, junipers, and Cyperaceae grasses. Their habitat significantly overlaps with livestock.
Amit Adhikari +4 more
wiley +1 more source
The Role of BIN1 in Alzheimer’s Disease [PDF]
, 2015 阿尔茨海默症（Alzheimer’sdisease,AD）是与年龄相关的神经退行性疾病，其主要的病理学特征为由β-淀粉样蛋白(-amyloid,Aβ)聚集产生的老年斑（senileplaues,SP）以及由异常磷酸化的tau蛋白组成的神经纤维缠结（neurofibrillarytangles,NFTs）。Aβ是由淀粉样前体蛋白（-amyloidprecursorprotein,APP）经过β-分泌酶和γ-分泌酶的依次顺序剪切而产生 ...
牛萌萌
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Conservation Biology, Volume 39, Issue 3, June 2025.Abstract Successful long‐term conservation relies on strategic planning for pragmatic actions to mitigate threats. Prioritizing actions and areas to support conservation goals in the most cost‐effective scenario becomes crucial in resource‐limited environments. However, planning and management can be challenging in data‐limited contexts.
Anna Karolina Martins Borges +3 more
wiley +1 more source
实验性阿尔茨海默模型大鼠海马内病理和PCNAmRNA表达的变化及rLent/NT4-NAP对其的影响
Zhongguo shiyan zhenduanxue, 2011 目的探讨实验性阿尔茨海默病模型大鼠脑内海马光镜下的变化和DNA修复蛋白PCNAmRNA表达的变化,进一步探讨神经保护肽慢病毒rLent/NT4-NAP（NAP）对其具有神经保护作用机制。方法选择无菌级雄性大鼠Wister大鼠40只,随机分为对照组,假手术组,阿尔茨海默（AD）模型大鼠组,rLent/NT4-NAP（NAP）组,每组10只。建立Aβ1-40联合应用转移生长因子β1（TGFβ1）注入实验大鼠左侧海马区制备阿尔茨海默动物模型,通过HE染色观察各组大鼠海马区的形态学改变 ...
白晶, 房绍宽, 张影, 周春奎
doaj
Zhongguo youzhi为了揭示雌、雄膨腹海马磷脂组成及其差异，用溶剂萃取法分别提取雌、雄膨腹海马脂质，冷丙酮提取其中的磷脂，进一步采用薄层色谱法和硅胶柱层析分离制备各磷脂组分，利用气相色谱技术分析比较雌、雄膨腹海马磷脂及其各组分的脂肪酸组成。结果表明：雌、雄膨腹海马的磷脂含量丰富，分别占总脂的18.11%和18.72%；膨腹海马磷脂包括磷脂酰乙醇胺、磷脂酰胆碱、溶血磷脂酰胆碱和鞘磷脂，其中磷脂酰胆碱含量最高；膨腹海马磷脂中共鉴定出20种脂肪酸，且不饱和脂肪酸含量高于饱和脂肪酸含量；雌、雄膨腹海马磷脂中海洋特征性n ...
吴娟娟1，田佳宁1，陈奕蒙1，王成成1，王玉明1,2 , 姜晓明1, 薛长湖1, 张恬恬1 WU Juanjuan1, TIAN Jianing1, CHEN Yimeng1, WANG Chengcheng1, WANG Yuming1,2, JIANG Xiaoming1, XUE Changhu1, ZHANG Tiantian1
doaj +1 more source
The effect of overexpressing SNX8 on the phenotype of Alzheimer’s mice [PDF]
, 2015 阿尔茨海默病（Alzheimerdisease，AD）是最为常见的神经退行性疾病。神经元胞外Aβ（Amyloidβ，Aβ）聚集形成的淀粉样斑是AD的一个重要的病理特征，而Aβ是由淀粉样前体蛋白APP（AmyloidPrecursorProtein，APP）经β-分泌酶（β-secretase）和γ-分泌酶（γ-secretase）依次切割后生成的（即淀粉样蛋白途径），而APP的另一条剪切途径是α-分泌酶（α-secretase）和γ-分泌酶依次对其进行剪切，释放有神经保护作用的sAPPα ...
纪成香
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China's Eco‐Civilisation, Climate Leviathan, and Hobbesian Energy Transition
Antipode, Volume 57, Issue 3, Page 830-861, May 2025.Abstract Scholars have hitherto tended to theorise China's ecological civilisation project either as a form of environmental authoritarianism or as a vision of eco‐socialism. This paper contributes to the conversation by conducting a textual analysis of Chinese scholarly discussions on eco‐civilisation.
David Chen
wiley +1 more source