Results 1 to 10 of about 2,154 (155)
Zhongshan Daxue xuebao. Yixue kexue ban泛凋亡是一种新发现的受调控的细胞死亡类型，具有细胞焦亡、凋亡和坏死性凋亡的关键特征，其分子基础依赖上游泛凋亡小体的精密调控，在感染性和炎症性疾病的病理生理过程中同时发生。既往研究普遍认为这些程序性死亡通路是彼此独立、互不关联的信号传导体系。然而，随着分子机制研究的不断深入，证据链日益表明，在这些死亡通路之间存在复杂的调控网络。研究者将这种各程序性死亡通路的交叉对话机制定义为泛凋亡。目前，已有研究证实泛凋亡与感染性疾病、神经系统疾病、肿瘤等多种人类疾病密切相关。此外，越来越多的研究结果表明，泛凋亡在缺血 ...
高翔, 冯博
doaj +9 more sources
浙江大学学报. 医学版副黏病毒是一类重要的呼吸道病原体，在儿童感染性疾病中具有重要临床意义。其感染过程中可诱导多种形式的程序性细胞死亡（PCD），这些PCD形式在病毒复制、传播及宿主免疫应答中发挥关键作用，显著影响病毒的生命周期及疾病进展。一方面，PCD通过清除被感染细胞有助于限制病毒扩散并激活宿主免疫应答，从而增强抗病毒防御能力；另一方面，过度或异常的细胞死亡可能导致组织损伤和免疫紊乱，为病毒复制提供有利环境，进而加重病情。如细胞凋亡通过外源性与内源性通路参与感染控制，同时亦可能被病毒操控以增强其扩散能力 ...
刘 叶 +3 more
doaj +2 more sources
Review of the role of pyroptosis in benign prostatic hyperplasia in old males [PDF]
, 2023 Pyroptosis, a new mode of programmed cell death, is primarily characterized by persistent cellular swelling that culminates in cell rupture. This process results in the release of large amounts of inflammatory factors, subsequently triggering an ...
CHEN Zixuan, LI Dong, LIU Min
core +1 more source
The research on FBW7 gene enhances antitumor effect of paclitaxel on pancreatic cancer through GSDME-mediated pyroptosis [PDF]
, 2023 Background and purpose: Pancreatic cancer is a highly malignant disease. Most patients are in advanced stage upon diagnosis. Systemic chemotherapy is an important treatment method, but the chemotherapy drug resistance to tumors brings many problems to ...
JIA Yuming, YE Zeng, DENG Yanli, LI Shengchao, ZHANG Zhilei, WANG Chao, XU Xiaowu, QIN Yi, PENG Li
core +1 more source
Improvement of alveolarization arrest in newborn rats with bronchopulmonary dysplasia via inhibiting alveolar epithelial cell pyroptosis [PDF]
, 2023 Objective·To study the effect of gasdermin D (GSDMD) inhibitor necrosulfonamide (NSA) on alveolarization arrest in lipopolysaccharide (LPS)-induced bronchopulmonary dysplasia (BPD) newborn rats via inhibiting alveolar epithelial cell pyroptosis.Methods ...
WANG Xingyun +2 more
core +1 more source
Advances on mechanisms of regulated cell death in neurotoxicity of aluminum [PDF]
, 2023 Aluminum is a light metal which is rich in the earth's crust and widely used. Recently, the adverse health effects of environmental and occupational aluminum exposure on human have attracted more and more attention. Aluminum exposure has toxic effects on
Guangzi QI +6 more
core +1 more source
, 2021 运动训练是脑卒中后康复治疗的主要手段。运动训练可以促进脑卒中后神经功能的恢复，其作用目前普遍认为与神经可塑性有关，但具体机制未明。运动训练的神经可塑性机制是当前脑卒中康复研究领域的热点问题。运动训练可以调节脑卒中后脑内血流动力学变化、血管新生、神经炎症反应、营养因子分泌、神经细胞死亡及新生等。本文基于国内外研究，探讨脑卒中后最适的运动干预方案，并结合我们团队在运动训练促进脑卒中后神经功能恢复方向所做的系列研究工作 ...
胡昔权
core +1 more source
PANoptosis 的分子作用机制及其在致盲性眼病中的作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 以往研究认为各种细胞死亡途径有其独特的调控机制，近年来随着对细胞死亡途径的进一步研究发现各种途径之间存在串扰和协调，进而有研究提出一种新的细胞死亡途径：PANoptosis，认为PANoptosis是由PANoptosome复合物调节的炎症性程序性细胞死亡途径，具有细胞焦亡、细胞凋亡和/或坏死性凋亡的关键特征，并不能被细胞焦亡、细胞凋亡、坏死性凋亡中任意一种死亡方式单独表征。特定的触发因素如病毒、细菌及真菌感染可以诱导宿主以PANoptosis的途径死亡。本文就PANoptosis的相关通路 ...
李青青, 刘莲
doaj
Research progress on the association between melatonin and hypertensive disorder complicating pregnancy [PDF]
, 2023 Melatonin (N-acetyl-5-methoxytryptamine) is a polypotent neuroendocrine lipid-soluble small molecule secreted mainly by the pineal gland. During gestation, melatonin levels in the mother at night rise as the pregnancy progresses and return to normal ...
KANG Wenhui +4 more
core +1 more source
低强度聚焦超声触发PLGA阿霉素在细胞内空化增加乳腺癌细胞死亡
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探讨低强度聚焦超声能否触发聚乳酸-羟基乙酸共聚物（PLGA）包裹阿霉素在细胞内的空化作用以增加4T1肿瘤细胞的死亡。方法采用双乳化溶剂蒸发法制备了负载阿霉素的聚乳酸-羟基乙酸共聚物（PLGA）纳米气泡。设立细胞内释药组，细胞外释药组，传统给药组，单独超声组和对照组。用流式细胞仪检测各组细胞的死亡情况，用细胞活力检测试剂盒（CCK8）检测各组的细胞增殖，细胞划痕检测各组的侵袭情况。结果超声组细胞核的红色荧光平均强度高于对照组，差异具有统计学意义（t=16.627，P<0.001）；聚乳酸 ...
黄盘辉, 罗琼, 严飞, 李绍林
doaj