Results 11 to 20 of about 2,155 (170)
Zhongshan Daxue xuebao. Yixue kexue ban泛凋亡是一种新发现的受调控的细胞死亡类型，具有细胞焦亡、凋亡和坏死性凋亡的关键特征，其分子基础依赖上游泛凋亡小体的精密调控，在感染性和炎症性疾病的病理生理过程中同时发生。既往研究普遍认为这些程序性死亡通路是彼此独立、互不关联的信号传导体系。然而，随着分子机制研究的不断深入，证据链日益表明，在这些死亡通路之间存在复杂的调控网络。研究者将这种各程序性死亡通路的交叉对话机制定义为泛凋亡。目前，已有研究证实泛凋亡与感染性疾病、神经系统疾病、肿瘤等多种人类疾病密切相关。此外，越来越多的研究结果表明，泛凋亡在缺血 ...
高翔, 冯博
doaj +9 more sources
World Medical &Health Policy, Volume 15, Issue 4, Page 414-434, December 2023., 2023 Abstract Cardiovascular disease (CVD) is the leading cause of death among American Indians and Alaska Natives (AIANs). Despite copious research on CVD incidence and outcome discrepancies, a social determinants of health (SDOH) focused framework on CVD risk factors and health outcomes in AIAN populations has not been undertaken.
Eric Leung +3 more
wiley +1 more source
World Medical &Health Policy, Volume 15, Issue 4, Page 587-612, December 2023., 2023 Abstract Drug overdose claimed more than 100,000 lives in the United States in 2021. Drug‐induced homicide (DIH) laws create specific criminal liability for individuals who provide drugs that cause or contribute to the death of another person. DIH prosecutions in the United States have increased substantially over the past decade despite the absence of
Jennifer J. Carroll +8 more
wiley +1 more source
Review of the role of pyroptosis in benign prostatic hyperplasia in old males [PDF]
, 2023 Pyroptosis, a new mode of programmed cell death, is primarily characterized by persistent cellular swelling that culminates in cell rupture. This process results in the release of large amounts of inflammatory factors, subsequently triggering an ...
CHEN Zixuan, LI Dong, LIU Min
core +1 more source
The global challenge of cancer governance
World Medical &Health Policy, Volume 15, Issue 4, Page 672-681, December 2023., 2023 Abstract The global cancer statistics are stark, accounting for nearly 10 million deaths in 2020, around one in six of all deaths globally. The World Health Organization estimates that 70% of these cancer deaths occur in low‐ and middle‐income countries and cancer will continue to rise as a proportion of deaths in these settings.
Neil Lunt
wiley +1 more source
The research on FBW7 gene enhances antitumor effect of paclitaxel on pancreatic cancer through GSDME-mediated pyroptosis [PDF]
, 2023 Background and purpose: Pancreatic cancer is a highly malignant disease. Most patients are in advanced stage upon diagnosis. Systemic chemotherapy is an important treatment method, but the chemotherapy drug resistance to tumors brings many problems to ...
JIA Yuming, YE Zeng, DENG Yanli, LI Shengchao, ZHANG Zhilei, WANG Chao, XU Xiaowu, QIN Yi, PENG Li
core +1 more source
Conservation Biology, Volume 37, Issue 1, February 2023., 2023 Abstract Invasive species can dramatically alter ecosystems, but eradication is difficult, and suppression is expensive once they are established. Uncertainties in the potential for expansion and impacts by an invader can lead to delayed and inadequate suppression, allowing for establishment.
Brian D. Healy +5 more
wiley +1 more source
Improvement of alveolarization arrest in newborn rats with bronchopulmonary dysplasia via inhibiting alveolar epithelial cell pyroptosis [PDF]
, 2023 Objective·To study the effect of gasdermin D (GSDMD) inhibitor necrosulfonamide (NSA) on alveolarization arrest in lipopolysaccharide (LPS)-induced bronchopulmonary dysplasia (BPD) newborn rats via inhibiting alveolar epithelial cell pyroptosis.Methods ...
WANG Xingyun +2 more
core +1 more source
Journal of Traumatic Stress, Volume 35, Issue 5, Page 1460-1471, October 2022., 2022 Abstract This study examined posttraumatic stress disorder (PTSD), complex PTSD, depression, and anxiety among U.K. rail workers. A cross‐sectional survey examining exposure to seven psychosocial hazards (bullying/harassment; verbal abuse; physical and sexual assault; and hearing about, seeing the aftermath of, or witnessing a fatality), working ...
Laurence A. Carnall +3 more
wiley +1 more source
Advances on mechanisms of regulated cell death in neurotoxicity of aluminum [PDF]
, 2023 Aluminum is a light metal which is rich in the earth's crust and widely used. Recently, the adverse health effects of environmental and occupational aluminum exposure on human have attracted more and more attention. Aluminum exposure has toxic effects on
Guangzi QI +6 more
core +1 more source