Results 21 to 30 of about 24,523 (167)

Ultrahigh‐Strength Soft‐Magnetic NiFeCoAl Multi‐Principal Element Alloys Enabled by Multiscale Heterostructure Design

open access: yesRare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Soft‐magnetic materials (SMMs) are indispensable for electrification and sustainable energy systems, yet their inherent mechanical fragility fundamentally limits applications under severe mechanical stresses. Enhancing the yield strength of SMMs is essential to prevent the degradation in magnetic performance and failure from plastic ...
Nairan Wang   +6 more
wiley   +1 more source

Engineering Ferritin Nanoparticles for Theranostic Probes Development [PDF]

open access: yes, 2016
疾病的诊断治疗学在近年来得到了巨大关注和广泛研究,以蛋白质为基础的纳米材料具有优异生物相容性、生物降解性、灵活的可修饰性等特点,在癌症的诊疗一体化研究上发挥着巨大作用。鉴于发展以蛋白质为核心的新型诊疗一体化探针具有重要的可应用和临床转化意义,我们在本论文中研究设计了多种以铁蛋白为核心的纳米材料,并着重探究了各种材料在诊疗一体化中的应用。主要内容概括如下: 第一章,我们简要介绍了肿瘤诊断治疗技术的发展和现状,着重探讨了肿瘤诊断治疗一体化的研究现状 ...
王占通
core  

Application‐Grade TiAl Single Crystal With Excellent Room‐Temperature Plasticity and Strength Prepared by Seeded Electromagnetic Confinement Directional Solidification

open access: yesRare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT In this study, a newly developed seeded electromagnetic confinement directional solidification (EMCDS) technique was employed to fabricate large‐scale TiAl single crystal ingots with a diameter of 32 mm, overcoming the long‐standing size limitations that have hindered their industrial application.
Wei Wang   +9 more
wiley   +1 more source

利用体外定点诱变技术构建人突变型α-L-艾杜糖醛酸酶基因

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2002
【目的】构建突变型α-L-艾杜糖醛酸酶基因(IDUA)cDNA, 为体外表达、鉴定突变的性质提供物质基础。【方法】 以野生型pcDNA3-IDUA 为基础质粒, 采用双引物法体外定点诱变技术, 引入突变E404X。【结果】突变区域经PCR-SSCP 和 测序证实诱导突变成功。【结论】本研究成功构建了突变型IDU A cDNA, 可用于下游的体外表达;此定点突变技术具有简便、 诱变效率高等优点, 是体外构建突变型基因的一种有效方法。
于洪枫   +3 more
doaj  

Functional analysis of Hedgehog gene in amphioxus embryogenesis and mutants construction related to the Hedgehog signaling pathway [PDF]

open access: yes, 2015
Hedgehog(Hh)基因在动物胚胎发育过程中有着重要的作用,该基因最早在果蝇中发现,参与果蝇分节极性(segmentpolarity)的形成及翅原基前后组织中心的建立;在海胆中,参与中胚层的分化;而在脊椎动物中,该基因主要参与中枢神经系统(CNS)、轴旁中胚层及附肢的发育。在头索动物文昌鱼中,前人基于Hh的表达谱分析,推测该基因参与神经管的发育及左右轴的建立,提出Hh对神经管腹侧神经元分化的作用可能是一原始特征。 本文用基因敲低、过表达和敲除3种方法对文昌鱼Hh基因在胚胎发育中的功能做了进一步研究 ...
王慧
core  

In vitro culture, cryopreservation, and field reintroduction of the endangered Mingan thistle

open access: yesConservation Biology, Volume 40, Issue 2, April 2026.
Abstract Current plant conservation efforts are hindered by, for example, poor seed germination, low viability, and insufficient propagation and preservation technologies. To address these problems, we devised an approach to plant conservation that integrates conservation, preservation, and restoration (CPR), which uses advanced in vitro techniques. We
Mukund R. Shukla   +4 more
wiley   +1 more source

中国人粘多糖贮积症Ⅰ型IDUA 基因突变的检测

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2001
【目的】检测中国人粘多糖贮积症Ⅰ 型患者IDUA 基因(IDU A )突变。【方法】采用PCR-SSCP 、PCR 产物直接 测序等技术对35 例粘多糖贮积症Ⅰ 型患者的IDUA 第2 、6 、7 、8、9 和10 外显子及其相邻区域进行突变筛查。【结果】本研究 筛查出7 种突变, 均为单碱基置换。一内含子区突变nt1486C※T ;一中性突变nt1945G※C ;1 种无义突变E404X;4 种错义突 变:F198L、L218V、A361T 和V454I 。【结论】中国人IDUA 在第2 、6 ...
于洪枫, 曾瑞萍, 林群娣
doaj  

Fault diagnosis and fault-tolerant control for nonlinear systems with linear output structure [PDF]

open access: yes, 2005
Article describes the process of fault diagnosis and fault-tolerant control for nonlinear systems with linear output ...
Shen, L., Wang, H., Yue, H.
core   +1 more source

Effects of Oxytetracycline on Population Growth and Genetic Diversity of Euplotesvannus (Marine Protist) [PDF]

open access: yes, 2016
抗生素作为一类环境污染物在海岸带生境中广泛存在,它们对海洋原生生物遗传多样性的影响还不清楚.本工作以一种海洋纤毛虫原生生物(扇形游仆虫(Euplotes vannus))为例,研究了一种常见四环类抗生素(土霉素)对其生长的影响,并通过单细胞(个体)分析,探索了抗生素对其大核基因组中核糖体小亚基RNA基因(SSU r DNA)序列多样性的影响.结果表明,与对照组相比,3个土霉素处理组(1,10和20μg/m L)中纤毛虫的自然增长率随土霉素浓度升高显著降低,细胞大小则呈增大趋势.SSU r ...
付娆   +3 more
core   +1 more source

Renewed coexistence as a conceptual reframing of animal reintroductions to foster sustainable human–wildlife coexistence

open access: yesConservation Biology, Volume 40, Issue 2, April 2026.
Abstract Wildlife reintroductions are socioecological processes entailing the intentional movement of organisms by people. In animal reintroductions, there is growing recognition of the importance of human dimensions and efforts to integrate these into reintroduction projects. To conceptually reframe reintroductions as processes of renewed coexistence (
Roger Edward Auster   +3 more
wiley   +1 more source

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