Results 21 to 30 of about 158,813 (205)

855例前列腺癌患者错配修复基因胚系突变临床研究

open access: yesZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2023
目的 了解前列腺癌患者错配修复(MMR)基因胚系致病性突变携带情况及MMR基因突变患者的临床病理特征。 方法 回顾性分析复旦大学附属肿瘤医院2018至2022年收治的855例前列腺癌患者的胚系基因测序数据,根据美国医学遗传学与基因组学学会遗传突变分类标准指南、Clinvar数据库和Intervar数据库评估突变的致病性。比较MMR基因突变患者(MMR+组)、携带除外MMR基因的DNA损伤修复(DDR)基因胚系致病性突变患者(DDR+MMR-组)、未携带DDR基因胚系致病性突变患者(DDR-组 ...
Bangwei Fang   +5 more
semanticscholar   +1 more source

中枢神经系统损害:髓鞘和轴突变化 [PDF]

open access: yes, 1980
髓鞘(图1,a)和轴突变化,是中枢神经系统损害中比较重要的一种病变。为了便于说明髓鞘和轴突变化的特征,先从其正常结构达起。 (一)髓鞘和轴突的正常结构 髓鞘是有髓神经纤维外面所见的鞘,其包在中央的神经纤维就是轴突 ...
封根泉, 孟繁荣
core   +1 more source

可瘪管定常流动突变 [PDF]

open access: yes, 1984
本文从较一般情况出发,提出了可瘪管定常流动突变的力学模型,导出了突变临界条件,分析了流体粘性、重力和外压轴向梯度的影响,讨论了几种简单情况。进而就其中的两种做了模型实验。结果表明 ...
陶祖莱, 席葆树, 丁启明
core  

两种裸藻的无叶绿体突变株

open access: yes, 2002
利用 Ofloxacin处理获得了纤细裸藻和中型裸藻无叶绿体突变株。吸收光谱测定和自荧光显微观察证明突变株无叶绿素合成 ,DAPI染色方法显示突变株细胞不存在质体 DNA,而无色的长变胞藻细胞中仍有可检测质体 DNA,说明二突变株质体已消失。 SDS ...
王江新,施之新,徐旭东
core   +2 more sources

中国东北地区非综合征性耳聋患者GJB2基因的致聋突变分析

open access: yesZhongguo shiyan zhenduanxue, 2006
目的分析58例中国东北地区非综合征性耳聋(nonsyndromic hearing impairment,NSHI)患儿GJB2基因突变类型和频率。方法收集吉林省吉林市聋哑学校的58例非综合征性耳聋患儿(分别来自57个家庭)及37例听力正常家属的血样,经聚合酶链反应(polymerase chain reaction,PCR)扩增GJB2基因编码区,用酶切方法初步分析已知的233-235位点,进一步行DNA测序证实酶切结果并发现新的突变类型;同时对部分家属进行DNA测序 ...
于飞   +11 more
doaj  

Root economic space is associated with rhizosphere microbial divergence via root metabolite‐mediated pathways in degraded grasslands

open access: yesFunctional Ecology, Volume 40, Issue 7, Page 2068-2082, July 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Grasslands worldwide are experiencing severe degradation due to overgrazing, climate change and anthropogenic disturbances, resulting in substantial declines in biodiversity and ecosystem functioning.
Xiaoqi Wang   +5 more
wiley   +1 more source

Developmental plasticity drives converge nt shifts in phosphorus acquisition strategies towards root phosphatase activity in Moso bamboo under nitrogen addition

open access: yesFunctional Ecology, Volume 40, Issue 7, Page 2221-2236, July 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Anthropogenic nitrogen (N) deposition is a major driver of global change. However, its effects on the developmental plasticity of plant nutrient strategies remain poorly understood.
Quan Li   +11 more
wiley   +1 more source

Threats to the World's Bears and Efforts to Conserve Them: Perspectives and Actions of IUCN Bear Specialist Group Members 世界熊类面临的威胁及其保护努力:IUCN熊类专家组成员的观点与行动

open access: yesIntegrative Conservation, Volume 5, Issue 2, Page 177-191, June 2026.
A survey of IUCN Bear Specialist Group (BSG) members revealed that habitat loss, degradation and fragmentation is the greatest threat to each of the 7 species of terrestrial bears. Poaching and human–bear conflicts are also high threats for some of these species.
David L. Garshelis   +3 more
wiley   +1 more source

Governing by Ambiguity: Sociotechnical Imaginaries of Platforms in China

open access: yesPolicy &Internet, Volume 18, Issue 2, June 2026.
ABSTRACT Besides clear policy directives, the unresolved and open‐ended elements in policy communication also create discursive politics. This article argues that ambiguity in policy communication reflects the state's exercise of power within a fractured sociocultural landscape.
Fangyu Qing, Ngai Keung Chan
wiley   +1 more source

Emerging MBenes for Energy Technologies

open access: yesRare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT The escalating global demand for sustainable energy is driving the search for transformative materials that transcend the limitations of conventional systems. Two‐dimensional (2D) transition metal borides (MBenes) have recently emerged as a compelling class, distinguished by unique electronic structures, tunable surface chemistry, and ...
Yingrui Ding   +5 more
wiley   +1 more source

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