Results 31 to 40 of about 158,813 (205)
Zhongguo shiyan zhenduanxue, 2017 目的分析吉林省耐多药结核分枝杆菌临床分离株rpoB、katG基因突变特点,为建立本省快速耐多药检测方法提供参考。方法对吉林省耐多药结核分枝杆菌菌株扩增rpoB、katG基因测序后比对分析。结果耐多药结核分枝杆菌rpoB、katG基因的突变率分别为83.53%和70.6%,突变类型包括点突变、联合突变和缺失。在rpoB基因中,82.30%突变发生在RRDR区域,最常见突变位点为rpoB 531、rpoB 526、rpoB 516。KatG基因突变率为70.6%,最常见突变位点为katG315 ...
张炜煜 +4 more
doaj
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT The development of structurally stable anodes with high capacities and long cycle lives is essential for the development of potassium–ion batteries. Conversion‐type anodes have attracted considerable attention in potassium–ion batteries (PIBs) due to their high theoretical capacities.
Jeong Ho Na +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2011 目的探讨K-ras基因突变谱与结直肠癌肝转移的相关性,为进一步阐明结直肠癌肝转移的分子机制提供理论依据。方法收集2008年1月至2010年8月在我院治疗的结直肠癌肝转移患者30例,进行K-ras基因突变检测,分析K-ras基因的突变类型及频率,探讨K-ras基因的突变谱与结直肠癌肝转移患者性别、年龄、原发灶位置、转移位置、病灶形态及TNM分期的相关性。结果 30例结直肠癌肝转移患者组织中K-ras基因突变者14例,突变率为47%,其中12密码子突变9例,突变率为30%;13密码子突变者5例,突变率为17%
王涛 +4 more
doaj
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT The strength and ductility trade‐off in titanium matrix composites (TMCs) is a critical factor limiting their widespread application. In this study, a (TiB + TiC)/Ti–6Al–4V composite with an optimal balance between strength and ductility was engineered via multi‐directional forging.
Chunyu Shen +8 more
wiley +1 more source
, 1999 基于简单的细观非线性动力学模型，采用相空间随机切片方法，考察了介质损伤破坏的耦合斑图非平衡系统演化。系统的行为呈现样本个性、跨尺度敏感性及突发性灾变等特征，称之演化诱致突变现象。通过系综演化模拟，得到了相应的统计分布。考察了宏观参数空间中过渡区范围的尺度效应 ...
白以龙, 白洁, 柯孚久, 夏蒙棼
core +1 more source
Individual Uncertainty and Policy Compliance During the COVID‐19 Pandemic
Risk, Hazards &Crisis in Public Policy, Volume 17, Issue 2, June 2026.ABSTRACT Ample scholarship examines the extent to which public policies in representative democracies reflect the priorities and needs of the public, often finding that individuals are unaware of many policy issues and policy responses. This may be especially true when issues of risk and scientific uncertainty are involved, which can be difficult for ...
Nathan Jeschke +6 more
wiley +1 more source
四川大学学报. 自然科学版, 2002 G6PD是磷酸戊糖旁路代谢的限速酶 ,也是重要的看家酶 .G6PD缺乏症是人类常见的遗传性疾病 .作者应用突变特异性扩增系统 (ARMS) ,对 2 1例G6PD缺乏症患儿进行基因检测 .结果在2 1例患儿中检出G1388A突变 7例 ,G1376T突变 4例 ,A95G突变 3例 ,未定型 7例 .成都常见的G6PD基因突变型为中国人中常见突变型 ,分析四川人群G6PD基因突变型 ,估计基因突变频率 ,可为四川省G6PD缺乏症的临床防治提供理论依据 .
杨春蕾 +4 more
doaj
Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 目的探讨肝硬化患者血浆游离DNA(cfDNA)中TERT基因-124(C/T)和-146(C/T)热点突变率及其突变与临床指标相关性。方法纳入航天中心医院2019年10月-2020年11月肝硬化患者80例,收集患者临床基本资料。EDTA抗凝全血分离500μL血浆提取cfDNA。TERT热点突变检测采用ARMS-qPCR方法。结果在80例肝硬化患者血浆cfDNA中,检测到TERT热点突变6例(7.5%),其中-124(C/T)4例(5%),-146(C/T)2例(2.5%)。与非突变组比较 ...
薛晓霞, 何美琳, 梁国威
doaj
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, Volume 37, Issue 3, Page 365-374, June 2026.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source