Results 31 to 40 of about 24,268 (167)
Governance of Climate‐Induced Relocation in the US: An Exploration of Institutional Complexity
Review of Policy Research, Volume 43, Issue 2, March 2026.ABSTRACT Climate change has and will continue to have a profound effect on both individuals and the communities in which they reside. A pressing question is how communities forced to confront climate‐induced catastrophe—including both rapid and slow‐onset hazards—undertake the decision of how and when to relocate, particularly given the multiple scales
Christopher S. Galik, Brad A. Johnson
wiley +1 more source
Functional Characterization of AtST39 in Stress Response and AtMPA Mediating Pollen Development [PDF]
, 2012 基因芯片显示番茄细菌性叶斑病原菌Pseudomonassyringaepv.tomatoDC3000(PstDC3000)，干旱、冷和盐等逆境处理及在开花关键基因lfy突变体中都能够上调AtST39（At3g46110）基因表达；AtMPA（At1g05577）在拟南芥单核花粉粒向三核花粉发育的过程中特异性表达。但是AtST39参与胁迫和AtMPA在介导花粉发育的分子机制知之甚少。我们主要对AtST39进行了探索研究，结果如下： （1）NCBI数据库显示YWC基因家族共有185个蛋白家族成员 ...
肖世民
core
Changing Policy Narratives in Addressing Indonesia's Deforestation
Review of Policy Research, Volume 43, Issue 2, March 2026.ABSTRACT Indonesia's forests stand at the crossroads of economic prosperity and ecological preservation, where the demand for timber and palm oil clashes with the urgent need to protect biodiversity and mitigate climate change. The dual role of Indonesia's forests has led to decades of policy tension, primarily contesting their function as engines of ...
Hafidz Wibisono +7 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】利用聚合酶链反应(PC R)技术对Wilson 病(WD)基因进行体外定点突变的研究。【方法】采用PCR 定点 突变技术, 首先设计两对引物, 将突变位点设计在引物上, 通过重叠延伸法两次PCR 扩增, 扩增片段上含有所需要的突变位 点, 最后将扩增片段克隆入pRc/ CMV 载体中。【结果】DNA 测序表明在预期位点已经发生突变,WD 基因第778 位密码子由 精氨酸(Arg)残基突变为亮氨酸残基(Leu), 用PCR 定点突变技术成功构建Wilso n 病基因突变体。【结论】PCR ...
闫振文 +4 more
doaj
Zhongguo shiyan zhenduanxue, 2021 目的探讨肝硬化患者血浆游离DNA(cfDNA)中TERT基因-124(C/T)和-146(C/T)热点突变率及其突变与临床指标相关性。方法纳入航天中心医院2019年10月-2020年11月肝硬化患者80例,收集患者临床基本资料。EDTA抗凝全血分离500μL血浆提取cfDNA。TERT热点突变检测采用ARMS-qPCR方法。结果在80例肝硬化患者血浆cfDNA中,检测到TERT热点突变6例(7.5%),其中-124(C/T)4例(5%),-146(C/T)2例(2.5%)。与非突变组比较 ...
薛晓霞, 何美琳, 梁国威
doaj
Plasma microRNA Associated with EGFR-TKI Primary Resistance in Non-Small Cell Lung Cancer with EGFR-Mutation [PDF]
, 2016 背景 肺癌是目前全世界范围内发病率和死亡率较高的恶性肿瘤之一。按组织学分类，肺癌可以分为两大类：小细胞肺癌（smallcelllungcancer，SCLC）和非小细胞肺癌（nonsmallcelllungcancer，NSCLC），小细胞肺癌占所有病例的20%，其余80%左右为NSCLC，包括鳞癌、腺癌、大细胞癌等类型。手术、放疗以及化疗等多学科综合治疗是指南推荐的NSCLC的首选治疗方式。由于NSCLC早期的典型临床症状和体征并不明显，约2/3的NSCLC患者在确诊时已发展为中晚期，失去手术根治机会。
潘小艳
core
Review of Policy Research, Volume 43, Issue 2, March 2026.ABSTRACT The future of work (FoW), that is, how new technologies from automation to artificial intelligence affect the workplace, has become such a salient topic that its framing matters for the evolution of important policy areas from social protection to market and labor regulation.
Achim Kemmerling, Viddy Ranawijaya
wiley +1 more source
European Policy Analysis, Volume 12, Issue 1, Winter 2026.ABSTRACT In the context of Europeanisation and neo‐corporatism, we examine the lengthy process of revising the Nondiscrimination Act in Finland, spanning from 2007 to 2023. The focus is on the mandate of the Nondiscrimination Ombudsman in the workplace and on explaining the sudden policy change of strengthening it after a prolonged standstill.
Laura Jauhola, Kati Rantala
wiley +1 more source
Regulation of PI3K and MAPK inhibitors on the activity of FOXO1 and their effect on biological behavior of GIST-T1 gastric stromal tumor cell lines [PDF]
, 2015 胃肠道间质瘤（gastrointestinalstromaltumors,GISTs）是消化道最常见的间叶组织肿瘤。目前普遍认为GISTs起源于向cajal细胞分化的原始间叶细胞或幼稚干细胞，具有多向分化特征，可以向平滑肌、神经分化或不定向分化，是一种具有恶性潜能的胃肠道肿瘤，但其确切起源尚不明确。其发病率为1～2/10万人口,似乎正逐渐增加。近年来有研究表明，PI3K（磷脂酰肌醇-3-激酶）和MAPK（丝裂原活化蛋白激酶）信号通路活性在胃肠道间质瘤显著增高 ...
高华
core
Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.This paper reports the preparation of a superhydrophobic composite coating using a spray‐coating method. The coating features PDMS and PVDF as organic bonding frameworks, doped with GPE, MWCNTs, and modified SiO2 functional nanoparticles to achieve efficient de‐icing.
Lei Li, Guodong Qin, Qier An
wiley +1 more source