Results 41 to 50 of about 38,595 (264)
The role of C-terminal region of Hepatitis B virus x protein on virus replication and cell death [PDF]
, 2016 在全球范围内，肝细胞癌（HCC）是临床上最常见的恶性肿瘤之一。乙型肝炎病毒（HBV）的持续感染是引起HCC的高危因素。乙型肝炎病毒（HBV）X蛋白（HBx）对于HBV的复制和HBV相关肝癌的发生发展起着重要的作用。本研究从HBV相关肝癌患者的癌、癌旁组织标本和血清标本出发，发现HBV相关肝癌组织的低复制性与HBx羧基端的截短突变有相关性。先前也有研究表明HBx羧基端截短突变体对于HBV的复制水平又不同程度的影响，但是所涉及的亚细胞结构靶点及参与的作用机制尚未阐明 ...
林碧芸
core
The Palestinians in a Transforming Middle East: Adapting or Stagnating
World Affairs, Volume 188, Issue 3, Fall 2025.ABSTRACT This article examines the profound stagnation and decline confronting the Palestinian national movement in the aftermath of the October 2023 war in Gaza. It argues that Palestinian political fragmentation has coincided with an evolving regional landscape that increasingly sidelines Palestinians. On the international stage, waning US engagement,
Anas Iqtait
wiley +1 more source
Extended Commentary—Israel's Relations With the UN: From “Om Shmum” Policy to Proactive Policy
World Affairs, Volume 188, Issue 3, Fall 2025.ABSTRACT This extended commentary discusses the changes over time in Israel's policy toward the UN from what may be termed an “Om Shmum” policy to a more proactive stance. I look at UN–Israel relations comprehensively and not only through the prism of Israeli–Palestinian or Israeli–Arab relations and analyze the reasons for the deterioration of Israel ...
Yaron Salman
wiley +1 more source
Regulation of PI3K and MAPK inhibitors on the activity of FOXO1 and their effect on biological behavior of GIST-T1 gastric stromal tumor cell lines [PDF]
, 2015 胃肠道间质瘤（gastrointestinalstromaltumors,GISTs）是消化道最常见的间叶组织肿瘤。目前普遍认为GISTs起源于向cajal细胞分化的原始间叶细胞或幼稚干细胞，具有多向分化特征，可以向平滑肌、神经分化或不定向分化，是一种具有恶性潜能的胃肠道肿瘤，但其确切起源尚不明确。其发病率为1～2/10万人口,似乎正逐渐增加。近年来有研究表明，PI3K（磷脂酰肌醇-3-激酶）和MAPK（丝裂原活化蛋白激酶）信号通路活性在胃肠道间质瘤显著增高 ...
高华
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Journal of Ecology, Volume 113, Issue 7, Page 1746-1759, July 2025.In forests dominated by large clonal plants, such as giant moso bamboo, drought can alter the allocation of newly assimilated C within the tissues of source ramet but may not affect its allocation among interconnected ramets or within plant–soil systems.
Xiaogai Ge +9 more
wiley +1 more source
The mechanism and function of extracellular matrix protein Mindin in the colon cancer progression [PDF]
, 2015 在世界范围内，结直肠癌是临床上常见的恶性肿瘤之一。结肠癌的发病机制也在不断细致、深入的研究。然而结肠癌这种实体肿瘤不像单纯的肠癌细胞系。相反，它是由多种类型的细胞和细胞外基质组成的功能失调的器官。细胞外基质是肿瘤微环境的重要组成部分，包含各种各样的细胞因子和代谢产物，具有向细胞传导各种环境信号的作用。这些信号对于细胞生命过程的方方面面都必不可少，包括增殖、分化和死亡等。然而，细胞外基质蛋白在结肠癌发生发展的演变过程中的作用尚未完全明确。 分泌型的细胞外基质蛋白Mindin作为Mindin-F ...
肖传兴
core
New Phytologist, Volume 247, Issue 2, Page 504-517, July 2025.Summary Repetitive DNA is a feature of all organisms, ranging from archaea and plants to humans. DNA repeats can be seen both in coding and in noncoding regions of the genome. Due to the recurring nature of the sequences, simple DNA repeats tend to be more prone to errors during replication and repair, resulting in variability in their unit length ...
Sridevi Sureshkumar +3 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】对1例斑驳病小家系中的先证者进行致病基因KIT和SLUG（SNAI2）编码序列的突变检测，寻找致病性 突变。【方法】应用PCR扩增KIT和SLUG基因编码区及外显子-内含子交界区，对PCR产物进行直接测序。在50例正常对 照中进行新突变的测序分析，以排除多态性。【结果】家系先证者SLUG基因检测未发现异常，KIT基因检测到1个国际数据 库中尚未报道的点突变c.860T>A（p.V287E），患者父母均未检测到此突变。该突变位于KIT基因编码蛋白的细胞外配体结 合区域 ...
邓伟平, 陈敏华, 戴少霞
doaj
S221T/D225Y mutations of Escherichia coli RecA can transfer RecA from cytoplasm to nucleus in HeLa cells [PDF]
, 2016 RecA/Rad51家族蛋白在进化上是非常古老而又保守的蛋白家族。大肠杆菌RecA基因在同源重组、DNA修复、SOS途径、突变和细胞分裂中起重要作用。人Rad51基因是大肠杆菌RecA基因的直向同源基因，两者起源于同一个祖先基因。人Rad51基因主要参与DNA的修复和重组，并且与肿瘤发生关系密切。原核细胞与真核细胞最大的区别在于原核细胞没有以核模为界限的细胞核，而蛋白质的入核转运机制是一个十分复杂的生物学过程，需要核孔复合体（NPC）、核定位信号(NLS)、核转运受体、RanGTP蛋白等共同参与 ...
孙旭利
core
Zhongshan Daxue xuebao. Yixue kexue ban, 2010 【目的】 观察24个常用STR基因座等位基因突变的现象及特点65377; 【方法】 对5 084例肯定亲权关系的案例进行分析,筛选等位基因突变事件,确定突变等位基因的来源,统计各STR基因座的突变率,分析突变的规律及其特点65377; 【结果】 在24个STR基因座中共观察到172个突变事件,STR基因座的突变率介于0 ~ 0.492%65377;每个突变案例的突变基因座数目为1 ~ 3个65377;突变模式符合逐步突变模式,最多突变步数为四步65377;父系突变与母系突变比例为3.55:165377;
doaj