Results 21 to 30 of about 61,800 (169)
Pyruvate kinase modulates the link between β‐cell fructose metabolism and insulin secretion
The FASEB Journal, Volume 39, Issue 7, 15 April 2025.Left: Supraphysiological fructose amplifies glucose‐induced insulin secretion (GIIS) through sweet taste receptor (STR)‐mediated PLCβ2 signaling in pancreatic β‐cells. Concurrently, the phosphorylation of fructose to fructose 1‐phosphate (F1P) occurs in conjunction with the conversion of ATP to ADP. Subsequently, F1P inhibits pyruvate kinase M2 (PKM2).
Naoya Murao +8 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 13, Issue 2, April 2025.At high concentrations (> 10 μM), the β‐adrenergic blocker propranolol paradoxically increased intracellular cAMP levels in pancreatic β‐cells. This led to PKA‐induced RYR2 phosphorylation and extracellular Ca2+ influx, leading to CICR from the ER. CICR activated TRPM5, which augmented β‐cell electrical activity, extracellular Ca2+ influx, and insulin ...
Naoya Murao +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2019 目的检测2型糖尿病早期肾病患者的尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和胱抑素-C的水平,并与无糖尿病肾病的患者进行比较,分析尿NGAL和胱抑素C水平与尿微量白蛋白相关性。方法入组126名2型糖尿病患者和30名无糖尿病肾病作为对照组进行横断面比较研究。分为3个研究组:2型糖尿病有微量白蛋白尿组,2型糖尿病无微量白蛋白尿组和无任何肾脏疾病的患者。统计研究对象中2型糖尿病病程时间和血糖状态。对所有受试者的血样集中储存在-20℃的冰箱中,批量检测尿微量白蛋白以及NGAL和胱抑素-C水平 ...
陈英 +5 more
doaj
Journal of Diabetes Investigation, Volume 16, Issue 4, Page 646-655, April 2025.This study examined the effects of high‐intensity interval fast walking training (IWT) compared to moderate‐intensity continuous walking training (CWT) on muscle strength, walking ability, and QOL in people with diabetes accompanied by lower extremity weakness.
Yasuko Ichihara +11 more
wiley +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 3, Page 303-310, March 2025.ABSTRACT Objective Globally, one in four pregnant women is classified as overweight or obese, based on their prepregnancy body mass index (BMI). Obese pregnant women are at increased risk of adverse pregnancy outcomes and long‐term cardiovascular disease that occurs earlier in life.
M. Charakida +6 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 糖尿病微血管并发症累及全身各个器官，导致糖尿病患者寿命下降和生活质量降低。血管新生是糖尿病微 血管并发症的基本病理特征，而血管新生抑制因子在血管新生平衡调控和糖尿病微血管并发症发生发展中起了重要作 用。本文就血管新生抑制因子与糖尿病微血管并发症的研究进展及治疗前景作一综述，包括血管新生抑制因子与糖尿病 各种微血管并发症（糖尿病视网膜病变、糖尿病足、糖尿病勃起功能障碍和糖尿病肾病等）等的关系，最后概述了糖尿病微 血管并发症的临床治疗现状与内源性新生血管抑制因子在其中的应用前景。
高国全
doaj
血清糖化白蛋白与内源性分泌型糖化终末产物受体比值对糖尿病并发冠心病危险的评估价值
Zhongguo shiyan zhenduanxue, 2007 目的测定糖尿病及糖尿病并发冠心病患者血清糖化白蛋白（GA）和内源性分泌型糖化终末产物受体（es-RAGE）水平,探讨GA与esRAGE比值对判断糖尿病并发冠心病和冠状动脉病变严重程度的价值。方法入选单纯2型糖尿病患者64例（糖尿病组）,2型糖尿病合并冠心病患者70例（糖尿病合并冠心病组）,并根据冠状动脉病变支数分为三个亚组:一支病变组（22例）,两支病变组（19例）和三支病变组（29例）。以42例健康者为对照（对照组）。测定各组血清GA和esRAGE水平,计算GA/esRAGE比值 ...
陈秋静 +6 more
doaj
Journal of Diabetes Investigation, Volume 15, Issue 12, Page 1732-1742, December 2024.We investigated the effects of glucokinase haploinsufficiency on the β‐cell mass and function in a mouse model of obesity and diabetes induced by a long‐term high‐fat, high‐sucrose diet. Our results showed that glucokinase haploinsufficiency prevents the progressive deterioration of pancreatic β‐cell mass/function and glucose tolerance in long‐term ...
Ikumi Shigesawa +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2013 随着2型糖尿病发病率的不断增加,糖尿病肾病（DN）已成为我国最常见的继发性肾脏疾病之一[1]。同时,DN也逐渐成为终末期肾病的主要原因,但并非所有糖尿病患者的肾损伤都为糖尿病肾病[2]。本文就疑似合并非糖尿病肾病的185例2型糖尿病患者的临床及病理做一下回顾性分析。
潘文波 +3 more
doaj
The Ulaanbaatar agreement: Revising diabetes terminology in Asia to combat stigma
Journal of Diabetes Investigation, Volume 15, Issue 11, Page 1533-1536, November 2024.Many Asian countries, including Japan, China, and South Korea, continue to use terms that reference sugar and urine, contributing to ongoing stigma, while most of the rest of the world seem to use terms related to the original “Diabetes,” meaning “to pass through.” The 16th Scientific Meeting of the Asian Association for the Study of Diabetes (AASD ...
Yutaka Seino +7 more
wiley +1 more source