Results 21 to 30 of about 215,989 (167)

Endogenous GIP signaling is indispensable for DPP‐4 inhibitor‐mediated metabolic control in mice

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 567-575, April 2026.
This study reveals that the metabolic benefits of DPP‐4 inhibitors, including improved glucose tolerance and reduced body weight, are completely abolished in GIP receptor‐deficient mice. These findings establish that endogenous GIP signaling, rather than GLP‐1, is the indispensable key player for the efficacy of this drug class.
Saki Kubota‐Okamoto, Sodai Kubota, Hiromi Tsuchida, Yanyan Liu, Seiya Banno, Toshinori Imaizumi, Taro Fujisawa, Yoshihiro Takahashi, Takehiro Kato, Yukio Horikawa, Katsumi Iizuka, Takaaki Murakami, Yuuka Fujiwara, Hitoshi Kuwata, Yuji Yamazaki, Yutaka Seino, Shin Tsunekawa, Daisuke Yabe   +17 more
wiley   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

心理困擾之評估與處置；以糖尿病憂鬱為例

, 2020
[[abstract]]糖尿病佔國人十大死因第五位，易併發其他慢性疾病，造成個人、家庭及社會之負擔。糖尿病患者罹病過程大部分會經歷一連串心理衝擊，伴隨發生心理困擾，高於一般族群。本文主旨為探討憂鬱等心理困擾如何影響糖尿病疾病控制，糖尿病與心理困擾發生之不良影響；介紹常用於糖尿病病人之憂鬱檢測量表及糖尿病憂鬱的處置，提供給臨床照護人員參考，並提 ...
吳淑芳
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Deletion of Tgf‐β1 From CD206+ M2 Macrophages Ameliorates Obesity‐Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Backgrounds Obesity and diabetes impair the ability of the muscle to regenerate, repair and remodel, resulting in a gradual decrease in muscle mass and function. However, the underlying mechanisms and effective therapeutic strategies remain poorly understood.
Muhammad Bilal, Le Duc Anh, Nguyen Quynh Phuong, Sana Khalid, Allah Nawaz, Memoona, Muhammad Rahil Aslam, Tomonobu Kado, Yoshiyuki Watanabe, Ayumi Nishimura, Yoshiko Igarashi, Aamir Sharif, Yasuhiro Onogi, Tsutomu Wada, Ryuji Hayashi, Kenichi Hirabayashi, Seiji Yamamoto, Takashi Nakagawa, Hisashi Mori, Isao Usui, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe   +22 more
wiley   +1 more source

妊娠糖尿病の診断基準に関する提案 [PDF]

, 1998
application/pdf妊娠は diabetogenic である. 妊娠中に発症または発見された糖代謝異常を妊娠糖尿病(Gestational Diabetes Mellitus : GDM)と呼んでいる. 分娩後, 幾年か経て母体が顕性糖尿病に進行する率の高いことと, 巨大児の多いことが問題である. 従来, 我が国の糖尿病診断基準の中に妊娠糖尿病はなかった.
大森, 安惠, 佐中, 真由実, 浜田, 悌二, 嶺井, 里美, 豊田, 長康   +4 more
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Evolving trends of antidiabetic agents stratified by age, kidney function and body mass index: Insights from a nationwide claims database

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 701-710, January 2026.
Abstract Aims To analyse prescribing trends in antidiabetic agents stratified by background characteristics among individuals with type 2 diabetes. Materials and Methods This retrospective study used a large‐scale database between 2015 and 2024 in Japan.
Kazuki Aoyama, Akira Okada, Hidehiro Kaneko, Tatsuhiko Azegami, Yuta Suzuki, Shu Meguro, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Toshimasa Yamauchi, Masaomi Nangaku, Norihiko Takeda, Hideo Yasunaga, Kaori Hayashi   +14 more
wiley   +1 more source

Increased HbA1c relative to actual glycemic control in patients treated with sodium–glucose cotransporter 2 inhibitors

Journal of Diabetes Investigation, Volume 17, Issue 1, Page 34-41, January 2026.
ABSTRACT Aims/Introduction Among patients with diabetes receiving sodium–glucose cotransporter 2 (SGLT2) inhibitors, HbA1c levels are higher than glycated albumin levels. This study therefore aimed to evaluate the discrepancy between HbA1c and glucose management indicator (GMI), an index of glucose management derived from continuous glucose monitoring,
Keigo Mizutani, Eita Uenishi, Takeshi Onoue, Ryutaro Maeda, Koji Suzuki, Tomoko Handa, Tomoko Kobayashi, Shintaro Iwama, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Masaki Okazaki, Atsushi Hashizume, Hiroshi Arima   +14 more
wiley   +1 more source

Social stigma of diabetes in Taiwan: An analysis of public perceptions and disease name unpleasantness

Journal of Diabetes Investigation, Volume 16, Issue 12, Page 2242-2249, December 2025.
ABSTRACT Aims Social stigma related to diabetes affects self‐care and psychological well‐being. In Taiwan, negative perceptions of “diabetes mellitus” may contribute to this stigma. This study explores public attitudes toward people with diabetes and the unpleasantness linked to the disease name.
Der‐Yan Han, Po‐Fang Tsai, Po‐Ju Hung, I‐Weng Yen, Shih‐Tzer Tsai, Mei Chang, Hung‐Yuan Li   +6 more
wiley   +1 more source

L‐Theanine Suppresses the Increase in Blood Glucose Levels in Mice During Glucose Tolerance Tests by Promoting Glucose Excretion in the Urine

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
L‐theanine suppresses the increase in blood glucose levels occurring during an OGTT in mice by promoting glucose excretion in the urine. While further investigation is needed to clarify the underlying mechanism, our study findings suggest that L‐theanine has the function of suppressing a rise in blood glucose levels and has the potential to contribute ...
Shinnosuke Yamaura, Koki Sadamori, Koichi Kawada, Kyosuke Uno, Reiko Konishi, Takashi Majima, Akira Mukai, Koji Komori, Nobuyuki Kuramoto, Kou Kawada   +9 more
wiley   +1 more source

中西医结合治疗糖尿病肾病疗效观察 [PDF]

, 2012
目的观察益气养阴、活血祛瘀中药联合西药治疗早期糖尿病肾病的疗效。方法将早期糖尿病肾病患者46例随机分为2组,治疗组23例,采用基础治疗方案加用益气养阴、活血祛瘀中药治疗,对照组23例仅采用基础方案治疗,2组均治疗8周。结果治疗组总有效率为87%,对照组总有效率为70%,2组比较有显著性差异 ...
陈敏, 俞翔
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