Results 21 to 30 of about 46,109 (166)

Risk of acute pancreatitis with DPP‐4 inhibitors versus SGLT2 inhibitors in medication‐naïve individuals with diabetes: A target trial emulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3033-3043, April 2026.
Abstract Aims We investigated whether dipeptidyl peptidase‐4 inhibitor (DPP‐4i) use was associated with a higher risk of acute pancreatitis compared with sodium–glucose cotransporter 2 inhibitor (SGLT2i) use in antidiabetic medication‐naïve individuals.
Takashi Tatewaki, Akira Okada, Yuya Kimura, Hideo Yasunaga   +3 more
wiley   +1 more source

Structure and function research of the nuclear receptor PPARγ and its novel selective regulator [PDF]

, 2016
过氧化物酶体增殖剂激活受体家族(PPARs)是一类配体依赖型的激活因子，它们是核受体超家族中的重要成员。PPARs是机体调节新陈代谢平衡的关键转录因子，因此PPARs也成为了研发治疗糖尿病，心血管疾病等代谢相关疾病药物的热门分子靶标。 糖尿病是困扰现代人健康的一组常见代谢性疾病，但是目前临床上仍然缺乏安全且有效的糖尿病治疗药物。噻唑烷二酮（Thiazolidinedione，TZD)类药物是经典的PPARγ完全激动剂，由于它能够改善由糖尿病引起的胰岛素耐受等症状，目前已经运用于临床治疗Ⅱ型糖尿病 ...
邱琳
core  

Endogenous GIP signaling is indispensable for DPP‐4 inhibitor‐mediated metabolic control in mice

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 567-575, April 2026.
This study reveals that the metabolic benefits of DPP‐4 inhibitors, including improved glucose tolerance and reduced body weight, are completely abolished in GIP receptor‐deficient mice. These findings establish that endogenous GIP signaling, rather than GLP‐1, is the indispensable key player for the efficacy of this drug class.
Saki Kubota‐Okamoto, Sodai Kubota, Hiromi Tsuchida, Yanyan Liu, Seiya Banno, Toshinori Imaizumi, Taro Fujisawa, Yoshihiro Takahashi, Takehiro Kato, Yukio Horikawa, Katsumi Iizuka, Takaaki Murakami, Yuuka Fujiwara, Hitoshi Kuwata, Yuji Yamazaki, Yutaka Seino, Shin Tsunekawa, Daisuke Yabe   +17 more
wiley   +1 more source

成人迟发性自身免疫性糖尿病的研究进展

Zhongguo shiyan zhenduanxue, 2019
糖尿病是由多种原因引起的一类以慢性高血糖为特征的代谢性疾病,近年来,糖尿病的患病率在迅速上升,根据国际糖尿病联合会的糖尿病图谱,世界上大约有4亿人患有2型糖尿病,每年有1000万人被诊断患有糖尿病[1]。按现行的分类标准,糖尿病主要分为1型糖尿病(T1DM)、2型糖尿病(T2DM)、妊娠期糖尿病等特殊类型糖尿病。有些T1DM患者发生在成年期,即成人迟发性自身免疫性糖尿病(laten-
宁利俐, 燕艳, 付希英, 李沫, 蔡寒青   +4 more
doaj  

Aldose reductase regulates miR-200a/miR-141 to impact TGFβ signaling and renal fibrogenesis [PDF]

, 2012
醛糖还原酶（aldosereductase，AR）是多元醇糖代谢支路的限速酶。已有很多研究证实AR在糖尿病并发症如糖尿病神经病、糖尿病视网膜病中起到重要的作用。我们前期的工作表明，AR的遗传缺失抑制了高糖引起的PKC/TGFβ的激活，进而显著减缓了C57BL/6小鼠糖尿病肾病的进程(Liuetal.，Diabetologia，2011)。然而，AR是如何调控TGFβ和肾细胞纤维化却不清楚。本研究因而在肾细胞和组织中探讨了AR对miR-200a/miR-141等表达的影响，以及miR-200a/miR ...
张晔
core  

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Evolving trends of antidiabetic agents stratified by age, kidney function and body mass index: Insights from a nationwide claims database

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 701-710, January 2026.
Abstract Aims To analyse prescribing trends in antidiabetic agents stratified by background characteristics among individuals with type 2 diabetes. Materials and Methods This retrospective study used a large‐scale database between 2015 and 2024 in Japan.
Kazuki Aoyama, Akira Okada, Hidehiro Kaneko, Tatsuhiko Azegami, Yuta Suzuki, Shu Meguro, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Toshimasa Yamauchi, Masaomi Nangaku, Norihiko Takeda, Hideo Yasunaga, Kaori Hayashi   +14 more
wiley   +1 more source

Increased HbA1c relative to actual glycemic control in patients treated with sodium–glucose cotransporter 2 inhibitors

Journal of Diabetes Investigation, Volume 17, Issue 1, Page 34-41, January 2026.
ABSTRACT Aims/Introduction Among patients with diabetes receiving sodium–glucose cotransporter 2 (SGLT2) inhibitors, HbA1c levels are higher than glycated albumin levels. This study therefore aimed to evaluate the discrepancy between HbA1c and glucose management indicator (GMI), an index of glucose management derived from continuous glucose monitoring,
Keigo Mizutani, Eita Uenishi, Takeshi Onoue, Ryutaro Maeda, Koji Suzuki, Tomoko Handa, Tomoko Kobayashi, Shintaro Iwama, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Masaki Okazaki, Atsushi Hashizume, Hiroshi Arima   +14 more
wiley   +1 more source

Social stigma of diabetes in Taiwan: An analysis of public perceptions and disease name unpleasantness

Journal of Diabetes Investigation, Volume 16, Issue 12, Page 2242-2249, December 2025.
ABSTRACT Aims Social stigma related to diabetes affects self‐care and psychological well‐being. In Taiwan, negative perceptions of “diabetes mellitus” may contribute to this stigma. This study explores public attitudes toward people with diabetes and the unpleasantness linked to the disease name.
Der‐Yan Han, Po‐Fang Tsai, Po‐Ju Hung, I‐Weng Yen, Shih‐Tzer Tsai, Mei Chang, Hung‐Yuan Li   +6 more
wiley   +1 more source

L‐Theanine Suppresses the Increase in Blood Glucose Levels in Mice During Glucose Tolerance Tests by Promoting Glucose Excretion in the Urine

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
L‐theanine suppresses the increase in blood glucose levels occurring during an OGTT in mice by promoting glucose excretion in the urine. While further investigation is needed to clarify the underlying mechanism, our study findings suggest that L‐theanine has the function of suppressing a rise in blood glucose levels and has the potential to contribute ...
Shinnosuke Yamaura, Koki Sadamori, Koichi Kawada, Kyosuke Uno, Reiko Konishi, Takashi Majima, Akira Mukai, Koji Komori, Nobuyuki Kuramoto, Kou Kawada   +9 more
wiley   +1 more source