Results 11 to 20 of about 9,864 (160)

The effect of electroacupuncture at ST25 on Parkinson's disease constipation through regulation of autophagy in the enteric nervous system

The Anatomical Record, Volume 306, Issue 12, Page 3214-3228, December 2023., 2023
Abstract The effectiveness and safety of electroacupuncture (EA) for constipation have been confirmed by numerous clinical studies and experiments, and there are also studies on the efficacy of EA for Parkinson's disease (PD) motor symptoms. However, there are few researches on EA for PD constipation.
Li‐Zhe‐Xiong Song, Na Xu, Zhi Yu, Hui Yang, Cheng‐cheng Xu, Zi Qiu, Jing‐wen Dai, Bin Xu, Xuan‐ming Hu   +8 more
wiley   +1 more source

Associations of per‐ and polyfluoroalkyl substance concentrations in the blood of Amur tigers and physiological parameters 东北虎血液中全氟和多氟烷基化合物浓度与生理参数的关系

Wildlife Letters, Volume 1, Issue 4, Page 163-170, December 2023., 2023
Per‐ and polyfluoroalkyl substances (PFASs), especially long‐chain perfluorinated carboxylates and perfluorinated sulfonic acids, were considered as global environmental contaminants due to their wide industrial and commercial applications and their threat to human and animal health.
Luyao Wang, Dan You, Haitao Xu, Wei Xie, Mengna Chen, Qinjie Chang, Hongyu Jiang, Yajun Wang   +7 more
wiley   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

Plasma mitochondrial DNA is elevated in maternal serum at first trimester and may serve as a biomarker for prediction of gestational diabetes mellitus 血浆线粒体DNA在妊娠早期孕妇血清中升高，可能成为预测妊娠期糖尿病的生物标志物

Journal of Diabetes, Volume 15, Issue 12, Page 1095-1102, December 2023., 2023
Highlights In the first trimester, the plasma mitochondrial DNA (mtDNA) was higher in women who developed gestational diabetes mellitus (GDM) than in women who did not develop GDM during their pregnancy. The increased levels of plasma mtDNA were independent of age and fasting plasma glucose levels in the first trimester.
Dushyant Kumar Sahu, Jessy Abraham
wiley   +1 more source

Stress hyperglycemia ratio is associated with systemic inflammation and clinical outcomes in diabetic inpatients with pneumonia on admission 糖尿病合并肺炎住院患者的应激性高血糖率与全身性炎症和临床结局相关

Journal of Diabetes, Volume 15, Issue 7, Page 545-556, July 2023., 2023
Highlights High stress hyperglycemia ratio (SHR) was associated with elevated systematic inflammation in diabetic inpatients with pneumonia on admission. In the absence of hypoglycemia on admission, SHR was of J‐shaped associations with adverse clinical outcomes in diabetic inpatients with pneumonia of different severity.
Bing Liu, Yu Chen, Liping Yu, Min Zhou
wiley   +1 more source

Autophagy in the retinal neurovascular unit: New perspectives into diabetic retinopathy 视网膜神经血管单元自噬:糖尿病视网膜病变的新视角

Journal of Diabetes, Volume 15, Issue 5, Page 382-396, May 2023., 2023
HighlightsAutophagy is closely related to retinal neurovascular units in diabetes retinopathy. Different cells participate in the occurrence and development of diseases through autophagy, and targeted autophagy may be a new direction of treatment in the future. Emphasized the close relationship between diabetic retinopathy (DR) and autophagy Summarized
Xiongyi Yang, Zexin Huang, Mei Xu, Yanxia Chen, Mingzhe Cao, Guoguo Yi, Min Fu   +6 more
wiley   +1 more source

Noninvasive genetic monitoring of Chinese pangolin (Manis pentadactyla) from Darjeeling district of Northwest Bengal, India 印度西孟加拉邦大吉岭地区中华穿山甲（Manis pentadactyla）的非损伤遗传监测

Wildlife Letters, Volume 1, Issue 1, Page 15-22, March 2023., 2023
Image of Chinese pangolin from study areas (top left), sampling location map (top right). Median joining network of Chinese pangolin population (size of circles represents the relative frequency of that haplotype present in the population). B) Demographic history of Chinese pangolin population estimated using Bayesian skyline plot.
Prajnashree Priyambada, Vinaya K. Singh, Abhishek Singh, Bheem D. Joshi, Supriyo Dalui, Lenrik K. Wangmo, Avijit Ghosh, Avantika Thapa, Sujeet K. Singh, Kailash Chandra, Lalit K. Sharma, Mukesh Thakur   +11 more
wiley   +1 more source

Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929 [PDF]

, 2015
Clnk/MIST在一系列细胞因子依赖的造血细胞系中表达，同时也在一些细胞因子非依赖的肥大细胞系中表达，并且能够与PLC，Grb2，ADAP和HPK-1等蛋白相互作用。 作为Blnk/SLP-76接头分子蛋白家族的第三个成员，Clnk参与免疫受体信号通路的正向调控。但是，在Clnk基因敲除鼠中，Clnk对T细胞，NK细胞和肥大细胞的正常分化和发育并不是必须的。 本论文发现了Clnk在免疫信号通路之外的一些功能。我们发现Clnk在一系列细胞因子非依赖的非造血细胞系中表达，比如L929 ...
徐盟
core   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

p32 regulates ULK1 stability and autophagy [PDF]

, 2015
细胞自噬是细胞在营养匮乏条件下，降解细胞内成分以维持细胞必要活动与生命的一种细胞进程。线粒体自噬是一种选择性的细胞自噬，功能紊乱的线粒体可以通过这种方式被自噬体降解。并且线粒体自噬代表了线粒体质量控制的一种方式，而这种方式对维持最佳的线粒体生物能学水平很重要。大量的研究都表明了，ULK1在诱导细胞自噬与线粒体自噬中的关键作用，但是关于ULK1自身调节的报道却很少。p32是一个具有分子伴侣功能的蛋白，在维持线粒体膜电位差以及氧化磷酸化中起到非常重要的作用。但是p32与线粒体稳态控制的关系却没有被研究清楚 ...
焦海峰
core