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貉源致病性肺炎克雷伯氏菌对喹诺酮类药物耐药表型及耐药基因检测
野生动物学报, 2019 为了检测貉源致病性肺炎克雷伯氏菌对喹诺酮类药物的耐药性与耐药基因携带情况并分析其相关性，通过K-B药敏纸片和PCR方法分别检测24株貉源致病性肺炎克雷伯氏菌对喹诺酮类药物耐药性与耐药基因。结果表明：24株貉源致病性肺炎克雷伯氏菌呈现多重耐药性，对左氧氟沙星、恩诺沙星、环丙沙星、诺氟沙星耐药性为70.8%—79.2%，耐4种抗生素的菌株有16株，占分离菌株的66.7%；24株貉源致病性肺炎克雷伯氏菌的耐药基因gyrB、oqxA、parC、parE、oqxB、ompF检出率在70.8%以上 ...
张召兴 1 +1 more
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Zhongguo shiyan zhenduanxue, 2020 目的通过分析会阴侧切分娩产妇感染病原菌的分布和耐药性,为临床治疗和抗菌药物的使用提供参考。方法对2016年8月至2018年12月期间在攀枝花市妇幼保健院进行会阴侧切分娩发生感染的34例产妇的伤口分泌物进行细菌培养、鉴定及药敏试验。结果 34例发生感染的产妇侧切伤口分泌物中共检出49株病原菌,其中包括革兰阴性菌31株,占比63.27%;革兰阳性菌18株,占比36.73%;真菌0株,占比0.00%。主要革兰阴性菌对庆大霉素、克林霉素、氧氟沙星和多粘菌素的耐药性都较高,且耐药率都在50.00%以上 ...
张丽 +4 more
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Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu +12 more
wiley +1 more source
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He +11 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2015 目的研究多药耐药鲍曼不动杆菌（MDRAB）的耐药机制,为临床有效治疗该菌感染提供依据。方法应用PCR技术对94株MDRAB进行耐药基因检测,比较8种耐药基因阳性组与阴性组菌株的耐药性。结果耐药基因检出率:VIM 35.1%、SIM 55.0%、TEM 59.6%、OXA-23 93.6%、OXA-24 52.1%、SHV 52.1%、PER-1 83.0%、IMP 2.1%;仅IPM、MEM、SAM在OXA-23基因阳性组与阴性组间,和SAM在SIM基因阳性组与阴性组间的耐药性有显著差异。结论 ...
池细俤 +4 more
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To Ban or Not to Ban: The UK's Hamlet Moment With Farm Antibiotics
Politics &Policy, Volume 53, Issue 6, December 2025.ABSTRACT This article applies the Multiple Streams Framework (MSF) to examine post‐Brexit antimicrobial resistance (AMR) governance in UK agriculture, focusing on the contested regulation of prophylactic antibiotic use in farm animals. The study reveals how Brexit created a structural policy window, yet political and ideological dynamics rendered it ...
George Asiamah
wiley +1 more source
Veterinary Dermatology, Volume 36, Issue 6, Page 862-869, December 2025.ABSTRACT Background Chronic cases of canine otitis externa (OE) often develop infections with Pseudomonas aeruginosa (PA). Given the organism's high level of resistance, veterinary surgeons often turn to compounded solutions. Limited data describing the stability and potency of compounded ceftazidime (CAZ) solutions are available, which may affect ...
McKenna Snidow +6 more
wiley +1 more source
热化疗逆转人肝癌细胞系HepG2/ADM多药耐药性的实验研究
Zhongguo shiyan zhenduanxue, 2007 目的研究热化疗对多药耐药人肝癌细胞系HepG2/ADM耐药性的影响并探讨相关的机制。方法通过MTT法测定热化疗对多药耐药人肝癌细胞系HepG2/ADM耐药性影响;利用流式细胞仪检测细胞内ADM浓度变化。结果热化疗使多药耐药人肝癌细胞系HepG2/ADM耐药性降低;细胞内阿霉素浓度提高。结论热化疗具有逆转多药耐药人肝癌细胞系HepG2/ADM耐药性的作用,可能与细胞内阿霉素浓度提高有关。
李玉, 王宁, 孙涛, 宋丽艳
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Veterinary Dermatology, Volume 36, Issue 6, Page 825-837, December 2025.Background: Inhibition of the Janus kinase pathway is an established treatment for allergic dermatitis. Objective: To evaluate the efficacy and safety of ilunocitinib for control of pruritus in dogs with allergic dermatitis in a randomised, double‐masked clinical trial.
Sophie Forster +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的建立人肝癌多药耐药细胞系并研究其耐药特性及机制。方法应用人肝癌细胞株HepG2,采用阿霉素（ADM）浓度梯度递增诱导法,建立多药耐药细胞系HepG2/ADM。相差显微镜观察细胞,用MTT法检测该耐药细胞株对多种化疗药物的多药耐药性,采用流式细胞术检测该耐药细胞表面多药耐药基因（mdr）的表达产物P糖蛋白（P-gp）、多药耐药相关蛋白（MRP）及谷胱甘肽硫转移系统（GSH/GST）的表达情况,应用RT-PCR检测MDR、MRP基因表达水平。结果HepG2/ADM对多种抗癌药物产生耐药 ...
王宁, 李玉, 刘洁
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