Results 21 to 30 of about 1,241,830 (150)
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu +12 more
wiley +1 more source
, 2011 目的高效液相色谱法（HPLC）测定血浆中顺铂（DDP）含量，研究载顺铂磁性纳米药物在家兔体内的药动学特征及其相关药动学参数。方法家兔12只，随机分为2组。分别于兔耳缘静脉注射3mg·kg^-1（按DDP含量计）剂量载顺铂磁性纳米药物和DDP，按设定时间于对侧耳缘动脉采血，通过改良HPLC法测定血浆中DDP浓度。以3P97药动学程序处理血浆药物浓度．时间数据，进行药动学分析。结果本实验单剂量静注DDP在家兔体内的药动学特征符合二室模型，载顺铂磁性纳米药物则符合三室模型。主要动力学参数与DDP相比 ...
谢民强 +5 more
core +5 more sources
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He +11 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的建立人肝癌多药耐药细胞系并研究其耐药特性及机制。方法应用人肝癌细胞株HepG2,采用阿霉素（ADM）浓度梯度递增诱导法,建立多药耐药细胞系HepG2/ADM。相差显微镜观察细胞,用MTT法检测该耐药细胞株对多种化疗药物的多药耐药性,采用流式细胞术检测该耐药细胞表面多药耐药基因（mdr）的表达产物P糖蛋白（P-gp）、多药耐药相关蛋白（MRP）及谷胱甘肽硫转移系统（GSH/GST）的表达情况,应用RT-PCR检测MDR、MRP基因表达水平。结果HepG2/ADM对多种抗癌药物产生耐药 ...
王宁, 李玉, 刘洁
doaj
To Ban or Not to Ban: The UK's Hamlet Moment With Farm Antibiotics
Politics &Policy, Volume 53, Issue 6, December 2025.ABSTRACT This article applies the Multiple Streams Framework (MSF) to examine post‐Brexit antimicrobial resistance (AMR) governance in UK agriculture, focusing on the contested regulation of prophylactic antibiotic use in farm animals. The study reveals how Brexit created a structural policy window, yet political and ideological dynamics rendered it ...
George Asiamah
wiley +1 more source
热化疗逆转人肝癌细胞系BEL-7402/ADM多药耐药性的实验研究
Zhongguo shiyan zhenduanxue, 2005 目的 研究热化疗对多药耐药人肝癌细胞系BEL- 74 0 2 /ADM耐药性的影响并探讨相关的机制。方法 通过MTT法测定热化疗对多药耐药人肝癌细胞系BEL -74 0 2 /ADM耐药性影响;利用流式细胞仪检测多药耐药相关基因（MDR）的表达产物P糖蛋白（P- gp）、多药耐药相关蛋白（MRR）、谷胱甘肽转移酶（GSH/GST）的表达。结果 热化疗使多药耐药人肝癌细胞系BEL- 74 0 2 /ADM耐药性降低;P -gp、MRP和GSH/GST的表达均有所下降。结论 ...
王宁, 杨海山, 刘洁, 李玉
doaj
Veterinary Dermatology, Volume 36, Issue 6, Page 862-869, December 2025.ABSTRACT Background Chronic cases of canine otitis externa (OE) often develop infections with Pseudomonas aeruginosa (PA). Given the organism's high level of resistance, veterinary surgeons often turn to compounded solutions. Limited data describing the stability and potency of compounded ceftazidime (CAZ) solutions are available, which may affect ...
McKenna Snidow +6 more
wiley +1 more source
, 1998 为了解耐甲氧西林葡萄球菌的耐药状况，并为临床预防与治疗提供依据，我们对61株葡萄球菌进行耐甲氧西林及14种常用抗菌素的耐药率测定。结果：耐甲氧西林金黄色葡萄球菌检出率为52.6%；耐甲氧西林凝固酶阴性葡萄球菌检出率为47.6%；耐甲氧西林葡萄球菌对14种抗菌素的耐药率及多重耐药性均高于甲氧西林敏感葡萄球菌。耐甲氧西林葡萄球菌对万古霉素敏感 ...
童青, 方莹
core