Results 41 to 50 of about 9,169 (174)
Veterinary Dermatology, Volume 36, Issue 1, Page 14-23, February 2025.Background – Bacterial identification and antimicrobial susceptibility testing is an important step in timely therapeutic decisions for canine superficial bacterial folliculitis (SBF), commonly caused by Staphylococcus pseudintermedius. Next‐generation sequencing (NGS) offers the appeal of potentially expedited results with complete detection of ...
Kimberly Smart +4 more
wiley +1 more source
The optimized expression technology of marine animal-sourced antimicrobial peptides in Pichia pastoris and the development of antimicrobial peptide as feedstuff additive [PDF]
, 2015 抗生素污染问题是目前影响我国水产养殖业可持续健康发展的重大科技问题，抗生素（antibiotics）作为常用抗菌药物，被广泛应用于水产养殖业，但是抗生素超标所引起的细菌耐药性问题已成为全球公共健康问题，因此寻找抗生素的有效替代品是目前国内外本领域的研究热点之一。抗菌肽（antimicrobialpeptide）是先天性免疫的重要组分，广泛存在于生物界的各个门类，进化上相对保守，具有广谱抗菌活性、且不会产生细菌耐药性，被预言为最有希望替代抗生素的天然药物，具有广阔的应用前景 ...
彭会
core
Rare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man +7 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2011 目的探讨呼吸道分离的金黄色葡萄球菌耐药情况、耐药的菌株是否有遗传稳定性,及对其他种类的抗生素有无交叉耐药。方法把试验菌株与标准菌株在不同含药平皿中接种传代,观察MIC值的变化,再测定遗传稳定性及有无交叉耐药。结果试验菌株与标准菌株多次传代后,耐药突变菌株获得的耐药性是稳定的。未对其他种抗生素发生交叉耐药。结论合理选用抗生素,监测细菌耐药性、掌握耐药机制等综合措施的实施,才能减缓细菌耐药性的增长。
王轶, 刘珊珊, 黄瑾
doaj
Screening the Drug Sensitivity Genes Related to GEM and CDDP in the Lung Cancer Cell-lines [PDF]
, 2009 Background and objective Screening of small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) cell lines with gemcitabine hydrochloride (GEM) and cisplatin (CDDP) related to drug sensitivity gene might clarify the action mechanism of anti ...
Chunyu YANG +3 more
core
Analyzing antimicrobial resistance as a series of collective action problems
Policy Studies Journal, Volume 52, Issue 4, Page 833-856, November 2024.Abstract Antimicrobial resistance (AMR) causes over 1.27 million deaths annually, making it one of today's most urgent health threats. Given its urgency, there are often calls for large‐scale global initiatives to address AMR. However, theories of collective action have yet to be applied to the problem in a systematic and holistic manner.
Isaac Weldon +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 1970年June L.Biedlerand[1]等在对中国仓鼠细胞对放射菌素的耐药性研究时发现对一种药物表现耐药的细胞,对一批无论在分子结构还是靶向特征均不同的药物同样表现耐药,遂将细胞对多种药物产生交叉耐药的现象称为多药耐药（multidrugresistance,MDR）,且推测这一现象可能与耐药细胞细胞膜结构功能相关,1976年Juiao和Ling[2 ...
魏小平, 陈树, 王春光, 郭喜平
doaj
野生动物学报, 2020 为调查东北地区狐源大肠杆菌中氯霉素类耐药菌株的耐药基因分布情况，根据其耐药表型和流行情况，指导临床上合理用药。本试验采用PCR技术对224株狐源大肠杆菌的氯霉素类耐药基因cmlA、cat和floR进行检测，并结合耐药表型进行分析。结果表明：7723%（173/224）的狐源大肠杆菌具有氯霉素类耐药基因，cmlA、cat和floR基因在分离株的检出率分别为3259%、4375%和3527%，不同来源的大多数菌株能检测出耐药基因，且有部分大肠杆菌可携带2种或3种耐药基因。
冯涛 1 富景宁 2 薛原 1
doaj
Integrating tuberculosis and antimicrobial resistance control programmes. [PDF]
, 2018 Many low- and middle-income countries facing high levels of antimicrobial resistance, and the associated morbidity from ineffective treatment, also have a high burden of tuberculosis. Over recent decades many countries have developed effective laboratory
Hanefeld, Johanna +3 more
core +2 more sources
Zhongguo shiyan zhenduanxue, 2013 目的分析氨基糖苷类高水平耐药（High Level Aminoglyeoside Resistant,HLAR）肠球菌的耐药性与耐药基因,并研究其耐药分子机制。方法采用VITEK-2全自动鉴定仪法测定53株氨基糖苷类高水平耐药肠球菌对11种抗菌药物的最小抑菌浓度,用聚合酶链反应（PCR）检测肠球菌转座子Tn917和Tnl546/Tn916、红霉素耐药基因ermB、毒力岛基因mefA、I类整合酶IntI1、氯霉素耐药基cat、表面蛋白基因esp,并对万古霉素耐药肠球菌（Vancomycin ...
徐韫健, 梁权辉, 刘长连
doaj