Research progress of ferroptosis in the occurrence and development of periodontitis [PDF]
Periodontal disease is a chronic infectious disease characterized by chronic inflammation and progressive destruction of the periodontal tissue. Ferroptosis, an iron-dependent form of programmed cell death, is primarily characterized by altered iron ...
SUN Ruiman, QIN Xu, ZHU Guangxun
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Zhongguo shiyan zhenduanxue, 2023 铜(Cu)是人体必须的微量元素,在线粒体呼吸、抗氧化防御和生物复合物合成等多种细胞生命过程中发挥重要辅助功能[1]。然而,生理条件下细胞内Cu浓度较低,Cu浓度小幅度升高可能引起细胞毒性,甚至导致细胞死亡[2]。细胞内铜的摄取、分布和消除等过程受到机体严格调控。基因突变导致Cu过量累积与多种致命性疾病的发生密切相关。因此,充分理解细胞内Cu积累和代谢机制对于疾病的治疗至关重要[3]。铜死亡是一种由Cu2+过度蓄积引发的细胞调控性死亡方式,不同于细胞凋亡、铁死亡和坏死[4]。铜死亡发生的过程如下 ...
单关月 +4 more
doaj
Research Progress in Ferroptosis during Postmortem Aging of Muscle and Its Relationship with the Quality of Fresh Meat [PDF]
Water-holding capacity, texture and color are important indicators of fresh meat quality. In China, drip loss and textural deterioration of fresh meat are critical problems in the meat industry, causing greater quality loss than that in developed ...
HAO Danni, TU Xiaohang, GUO Shiyu, ZHU Yongzhi, WANG Daoying, XU Weimin, LI Pengpeng
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Astaxanthin Reduces Retinal Damage in Diabetes Mice by Inhibiting Iron Death through Regulating Nrf2/Gpx4 Signaling Pathway [PDF]
Objective: To investigate the effect and mechanism of astaxanthin on retinal damage in diabetes mice. Methods: The mice were randomly divided into four groups: Normal group, model group, low-dose astaxanthin group and high-dose astaxanthin group. Retinal
Jia LIU +6 more
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Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors [PDF]
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism.
CHE Xin +3 more
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Inhibitory Effect and Mechanism of Procyanidin B2 on High Glucose-Induced Ferroptosis in SH-SY5Y Cells [PDF]
Objective: To investigate the neuroprotective effect and mechanism of procyanidin B2 on high glucose-induced ferroptosis in differentiated SH-SY5Y cells.
WANG Jiaqi, CHEN Xiuting, XIA Xing, ZHOU Jinling
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Advances in fatty acid metabolism reprogramming of lung cancer [PDF]
, 2023 Lung cancer is the most common malignant tumor and the leading cause of cancer-related mortality. Although the development of targeted therapy and immunotherapy has significantly improved the efficacy and prognosis of lung cancer patients, the overall 5 ...
WU Jing, ZHOU Juan, SU Chunxia
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Establishment of a prognostic risk scoring model for patients with pancreatic ductal adenocarcinoma based on cell ferroptosis-related genes and its application value [PDF]
Objective To establish a prognostic risk scoring model for patients with pancreatic ductal adenocarcinoma (PDAC) based on cell ferroptosis-related genes, and to investigate its application value.
QING Gong, JING Xue, JIANG Yueping
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浙江大学学报. 医学版副黏病毒是一类重要的呼吸道病原体，在儿童感染性疾病中具有重要临床意义。其感染过程中可诱导多种形式的程序性细胞死亡（PCD），这些PCD形式在病毒复制、传播及宿主免疫应答中发挥关键作用，显著影响病毒的生命周期及疾病进展。一方面，PCD通过清除被感染细胞有助于限制病毒扩散并激活宿主免疫应答，从而增强抗病毒防御能力；另一方面，过度或异常的细胞死亡可能导致组织损伤和免疫紊乱，为病毒复制提供有利环境，进而加重病情。如细胞凋亡通过外源性与内源性通路参与感染控制，同时亦可能被病毒操控以增强其扩散能力 ...
刘 叶 +3 more
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Role of ferroptosis in acute cadmium-induced liver injury in mice [PDF]
Objective To investigate the role of ferroptosis in acute liver injury induced by cadmium (Cd) exposure in mice. Methods Healthy and clean male ICR mice of 8-10 weeks were randomly divided into control group, and Cd exposure group.
GUO Siyu +6 more
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