Results 31 to 40 of about 1,375 (156)
Air pollutants as drivers of cellular stress in neurons and microglia in the brain [PDF]
Air pollution is a growing global health concern, with increasing evidence linking exposure to particulate matter (PM) to neurodegenerative diseases such as Alzheimer’s disease (AD).
Yan, Hong
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Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探究丙烯醛是否能够诱发体内外发生铁死亡现象。方法体外：给予小鼠海马神经元细胞系HT22细胞丙烯醛进行造模，采用铁死亡抑制剂铁抑素-1（Fer-1）与去铁胺（DFO）进行保护。MTT法检测细胞存活率；自由基探针二氢乙啶（DHE）与亚铁探针FerroOrange检测细胞内自由基与亚铁离子含量；透射电镜观察正常与模型组的线粒体超微形态与结构；Western blot法检测铁死亡相关蛋白表达的情况。体内：雄性C57BL/6小鼠，7~8周龄每日给予3 mg/kg的丙烯醛分别进行造模1、2、4周 ...
彭伟嘉 +4 more
doaj
Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease [PDF]
Ferroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction.
CAI Xiaoyu +3 more
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Potential role of SUMO-specific proteases 1 in ferroptosis [PDF]
Objective·To explore the potential role of SUMO-specific protease 1 (SENP1) in ferroptosis.Methods·The Cancer Genome Atlas (TCGA) database was used to analyze the correlation between the expression levels of SENP1 and the ferroptosis-related genes, acyl ...
BAI Meng +5 more
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The research on FBW7 gene enhances antitumor effect of paclitaxel on pancreatic cancer through GSDME-mediated pyroptosis [PDF]
, 2023 Background and purpose: Pancreatic cancer is a highly malignant disease. Most patients are in advanced stage upon diagnosis. Systemic chemotherapy is an important treatment method, but the chemotherapy drug resistance to tumors brings many problems to ...
JIA Yuming, YE Zeng, DENG Yanli, LI Shengchao, ZHANG Zhilei, WANG Chao, XU Xiaowu, QIN Yi, PENG Li
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Regulatory effect of 5'tRF-LysCTT on ferroptosis in mouse cardiomyocytes and its mechanism [PDF]
Objective To investigate the regulatory effect of tRNA-derived small RNA (tsRNA) on ferroptosis in mouse cardiomyocytes and its mechanism. Methods RT-qPCR was used to measure the relative expression level of 5'tRF-LysCTT in the heart, liver, spleen ...
ZHAO Yan, WANG Kai, CHENG Xueli, WANG Kun
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Agrimoiin promotes NRF2-mediated ferroptosis of gastric cancer cells by inhibiting the PI3K-AKT pathway [PDF]
Objective To observe the inhibitory mechanism of agrimoiin on human gastric cancer cell line HGC-27 and MKN-45. Methods Gastric cancer HGC-27 and MKN-45 cells were divided into control group, different doses of agrimoniin groups, capecitabine (positive ...
CHI Wencheng +4 more
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Community‐informed and codesigned research to understand the impacts of railways on wildlife
Conservation Biology, Volume 39, Issue 5, October 2025.Abstract Trains cause mortalities of several animal species, but the ecological impacts of railways are understudied. Most research on wildlife–train collisions has focused on large mammals, but understanding railway‐specific risks for underrepresented taxa, especially vulnerable species, is important for developing effective mitigation strategies ...
Kyle D. Vincent +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2023 目的 本研究利用机器学习探索IgA肾病(IgAN)铁死亡的潜在诊断标志物及其生物学过程，并研究其与IgAN免疫细胞浸润的关系。方法 从GEO数据库中下载来自IgAN患者和对照组的肾小球组织的微阵列数据集(GSE93798,GSE104948),通过FerrDb数据库获取全部铁死亡相关基因数据，获得IgAN组和对照组中有差异表达的铁死亡相关基因 ...
杨柏新 +4 more
doaj
The role of ferroptosis suppressor protein 1 in tumors [PDF]
Ferroptosis suppressor protein 1 （FSP1） is a key suppressor in the process of ferroptosis， which can prevent cell death and has important biological functions and potential value in clinical application.
LI Hantong, LI Yuefan, ZHOU Yan, WANG Lin
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