Results 31 to 40 of about 1,248 (94)
Zhongguo shiyan zhenduanxue, 2023 目的 探究表没食子儿茶素没食子酸酯(EGCG)对阿霉素诱导下的心肌细胞铁死亡的影响及其保护机制。方法 体外培养大鼠H9C2心肌细胞，将H9C2心肌细胞分为4组：control组、DOX组、EGCG+DOX组、EGCG+DOX+ML385组进行对应的药物处理。DCFH-DA探针法检测活性氧(ROS);试剂盒检测线粒体膜电位(MMP)、丙二醛(MDA)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)、铁离子(Fe2+);Western blot检测谷胱甘肽过氧化物酶4(GPX4)、核因子E2相关因子2 ...
左振岐, 刘春辉
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Diagnosis of iron overload and heart disease by magnetic resonance imaging
Thalassemia Reports, 2011 The use of Magnetic resonance imaging (MRI) to estimate tissue iron was initiated nearly three decades ago but has only become a practical reality in the last ten years.
J.C. Wood, L. Noetzli
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The inherited diseases of haemoglobin are an emerging global health burden
Thalassemia Reports, 2011 Thalasseamia is one of the common genetic disorders. A genetic defect causes reduction of the globin chains leading to chronic haemolytic anaemia from birth.
S. Fucharoen, P. Winichagoon
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Cardiac failure in β-thalassemia: diagnosis, prevention and management
Thalassemia Reports, 2011 Heart failure always represented and still remains the leading cause of mortality in β (β)-thalassemia, despite the therapeutic advances and the considerable amelioration of prognosis accomplished over the last decades.
A. Aessopos, D. Farmakis, V. Berdoukas
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Zhongshan Daxue xuebao. Yixue kexue ban铁与高血压的关系近年来已成为心血管领域的重要前沿方向。铁死亡（ferroptosis）作为近年发现的一种铁依赖性细胞死亡形式，已被证实在多数心血管疾病及其相关疾病的发生发展中扮演着十分重要的角色。铁死亡的核心机制涉及铁代谢紊乱、脂质过氧化反应以及抗氧化系统的损伤，这些机制在高血压的病理进程中起着重要作用。铁死亡中铁代谢失衡和脂质过氧化这两者是导致高血压疾病相关血管损伤、血管重构以及高血压靶器官损害的关键因素。本文系统梳理了铁死亡与高血压之间的分子关联及其病理生理机制网络，重点探讨了铁死亡中铁代谢紊乱 ...
刘琪悦, 刘丽军
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浙江大学学报. 农业与生命科学版To investigate the regulatory effect of glycyrrhizic acid (GA) against kidney injury in fluoride-exposed mice, fifty male C57BL/6J mice were randomly divided into five groups: control group, sodium fluoride (NaF) treatment group, NaF＋low-dose GA ...
Li Meiyan(李美艳) +7 more
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β-地中海贫血症患者血清铁调素hepcidin、GDF15表达及与预后的关系
Zhongguo shiyan zhenduanxue, 2022 目的 观察β-地中海贫血症患者血清铁调素hepcidin、生长分化因子15(GDF15)表达水平变化，并分析其与预后的关系。方法 选取汉川市人民医院106例β-地中海贫血症患者（研究组），并选取同期50例体检健康者纳入对照组，检测其血清hepcidin、GDF15水平，随访2年，记录患者生存情况，采用Logistic回归模型分析其预后影响因素。结果 轻型组、重型组与中间型组血清hepcidin水平明显低于对照组（P0.05）;GDF15水平为：重型组>中间型组>轻型组>对照组（P0.05）；死亡组Hb ...
李秀, 谢玉文, 陈会荣
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Zhongguo shiyan zhenduanxue目的 探究C-C趋化因子受体10(C-C chemokine receptor 10,CCR10)在结直肠癌(colorectal cancer, CRC)中对细胞增殖和铁死亡的影响，并探究其影响铁死亡的机制。方法 在GEPIA数据库(Gene Expression Profiling Interactive Analysis)共表达分析CCR10与铁死亡关键基因的相关性。构建慢病毒介导的CCR10过表达(CCR10-OE)、敲除(CCR10-KO)及其阴性对照(NC)稳转HCT116细胞，采用细胞活力(
徐昰栋 +6 more
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Pulmonary hypertension: an emerging risk in hemoglobin disorders
Thalassemia Reports, 2011 Pulmonary hypertension (PH) is one of the main cardiovascular complications in haemoglobinopathies and is considerably implicated in patients’ morbidity and mortality.
D. Farmakis, A. Aessopos
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SAS诱导氧化应激时人卵巢癌顺铂敏感细胞与耐药细胞死亡方式的差异
Zhongguo shiyan zhenduanxue, 2018 目的利用柳氮磺吡啶(Sulfalsalazine,SAS)诱导氧化应激,探讨卵巢癌非耐药细胞与耐药细胞死亡方式的差异。方法选用人卵巢癌顺铂敏感细胞SKOV3和顺铂耐药细胞SKOV3/DDP,实验分组为对照组(Con),SAS各剂量组。应用铁死亡抑制剂Fer-1,实验分组为对照组,SAS组,Fer-1组,Fer-1与SAS联合作用组。应用程序性坏死抑制剂Nec-1,实验分组为对照组,SAS组,Nec-1组,Nec-1与SAS联合作用组。MTT法检测细胞生存率,实时无标记细胞功能分析法(Real time ...
高玮男 +4 more
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