Results 81 to 90 of about 1,375 (156)
Research progress in ceruloplasmin regulation of lipid metabolism homeostasis [PDF]
Ceruloplasmin (Cp) is a crucial protein secreted by the liver and plays a vital role in regulating the distribution and transport of copper throughout the body, thereby maintaining copper homeostasis.
CHEN Suzhen, JIANG Quanxin, LIU Junli
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Zhongshan Daxue xuebao. Yixue kexue ban血管性痴呆（VD）是一种由脑血管疾病造成的慢性进行性认知障碍，其发病机制复杂，主要包括神经细胞凋亡、氧化应激反应、炎症反应、铁死亡、线粒体损伤等因素导致的脑组织损伤。其中，氧化应激在VD发生发展中起关键作用，其可致自由基积累，破坏细胞结构，且与炎症反应、线粒体损伤、铁死亡、神经细胞凋亡密切相关，共同构成了一个复杂的致病网络，而中药单体在通过调控氧化应激治疗VD有显著效果。本文综述相关研究进展，探讨了氧化应激在VD中的作用机制，其通过Nrf2、LRP3、NF-κB等因子调控炎症反应 ...
陈信朝, 董新刚
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Platycoside G1 Inhibits Hepatocyte Senescence by Regulating Autophagy [PDF]
To investigate the effects of platycoside G1 (PG1) on senescent cells, it was determined that PG1 exerts a specific inhibitory effect on the senescent phenotype of hepatocytes by employing β-galactosidase staining and the cell counting kit-8 (CCK-8 ...
LI Yiquan, LI Yaru, LIU Yunyun, ZHAO Renshuang, ZHAO Zhehao, WU Changzheng, ZHANG Biao
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浙江大学学报. 医学版神经退行性变性疾病是一类由大脑和脊髓神经元退化并死亡所引发的疾病，至今缺乏有效的治疗方法。过氧亚硝酸盐是一种神经毒性物质，研究表明体内活性氧的过度积累与神经退行性变性疾病紧密相关。有效清除过氧亚硝酸盐的策略可能成为治疗神经退行性变性疾病的一种潜在途径。一些水溶性金属卟啉因其高效的过氧亚硝酸盐清除能力备受关注，常见金属卟啉如铁卟啉和锰卟啉通过抑制淀粉样斑块聚集、减轻氧化应激和神经炎症损伤、改善线粒体功能以及减少神经细胞凋亡等发挥神经保护作用。部分金属卟啉的血脑屏障穿透性不佳，除采用传统的合成工艺外 ...
陈 洁 +5 more
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Protective effect of dihydromyricetin against hippocampal neuronal injury caused by iron overload and its mechanism [PDF]
Objective To investigate the protective effect of dihydromyricetin (DMY) against injury of primary hip-pocampal neurons caused by ferric ammonium citrate (FAC) and its mechanism.
SUI Yunjie, MA Zegang
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Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness [PDF]
Tenderness is one of the most important indicators to judge meat quality, and it is also the most important sensory index for consumers to choose meat.
DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong
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Research Progress on Mechanism of NAD+ Metabolic Remodeling in Occurrence and Development of Glioblastoma Multiforme [PDF]
Gliomas, especially high-grade gliomas such as glioblastoma multiforme (GBM), are primary malignant tumors of the central nervous system, characterized by high proliferative capacity, invasiveness, and therapeutic resistance.
Chengwen WANG +6 more
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“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer [PDF]
Breast cancer is the most common malignant tumor among women worldwide, with incidence rates rising annually. The treatment of breast cancer has undergone significant transformations, evolving from an initial reliance on a single surgical approach to the
ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin
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Zhongshan Daxue xuebao. Yixue kexue ban随着全球人口老龄化进程的加快，肌少症作为一种以骨骼肌质量、力量与躯体功能持续性下降为特征的老年综合征，已成为严重威胁老年人健康和生活质量的重要公共卫生问题。其发生发展过程涉及多层次、跨系统的细胞与分子机制。近年来研究发现，程序性细胞死亡（PCD）在骨骼肌稳态维持、代谢调节与组织修复中发挥核心作用。凋亡、自噬、焦亡与铁死亡等典型PCD形式通过活性氧（ROS）积聚、线粒体功能障碍与铁稳态破坏等关键节点相互串扰，驱动肌纤维丢失、肌肉功能减退及慢性炎症反应，是肌少症发生发展的重要病理基础 ...
史雪珂, 冯晓东
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Shuitu Baochi Xuebao, 2011 为确定土壤铜、硫污染对苹果幼树生长发育的影响,以硫铁矿尾矿砂河滩垫地上栽植的苹果幼树为试材,研究土壤中的不同铜硫含量对苹果幼树生长发育的影响。结果表明:土壤中的铜含量≥46.8mg/kg,土壤有效硫含量≥368.7mg/kg时,苹果幼树的生长发育就会受到抑制;土壤中的铜含量≥53.9mg/kg,土壤有效硫含量≥538.0mg/kg时,苹果幼树受毒害甚至死亡。苹果幼树各器官铜含量的分布规律为:根系>叶片>新梢>1年生枝>2年生枝>主干,硫含量分布规律为:叶片>根系>新梢>1年生枝>2年生枝>主干 ...
董丽欣 +6 more
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