Results 21 to 30 of about 23,165 (115)
Conservation Biology, EarlyView.Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta +24 more
wiley +1 more source
Research of diagnostic biomarkers in Breast cancer and Gastric cancer [PDF]
, 2013 自生物标志物（biomarker）这一概念提出以来，肿瘤生物标志物（tumorbiomarker，TBM）在基础医学领域的研究已成为热点。本文基于大量的临床病理样本，利用免疫组织化学、甲基化芯片分析、实时荧光定量PCR等技术，研究乳腺癌、胃癌预后诊断的生物标志物，为疾病的治疗提供新的思路和靶点。 我们利用免疫组织化学，调查了酪氨酸磷酸酶Shp2和它的伴侣蛋白Gab2在141例乳腺浸润性导管癌中的表达，并分析了他们与临床病理学特征的相关性，发现Gab2蛋白表达与病人的年龄存在显著相关性 ...
陈宝珍
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Conservation Biology, EarlyView.Abstract Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species.
Louise Mair +17 more
wiley +1 more source
Clinical significance of Twist, Bmi-1 and E-cadherin expression in Cervical Intraepithelial Neoplasia and Early Stage Cervical Cancer [PDF]
, 2015 目的：研究Twist/Bmi-1/E-cadherin蛋白在早期宫颈癌组织、宫颈上皮内瘤变（CIN）组织与正常宫颈组织中的表达水平，探讨Twist/Bmi-1/E-cadherin在早期宫颈癌不同病变组织中表达的生物学意义，对宫颈癌患者预后的影响以及这三者之间的相关性。 方法：收集2009年7月—2013年10月在厦门大学附属中山医院手术切除的64例宫颈癌，41例CIN组织，12例正常宫颈组织石蜡标本，运用Elivision免疫组化法检测Twist/Bmi-1/E-cadherin在宫颈癌组织 ...
丁娅妮
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Overreliance on Orthographic Similarity in L2‐Japanese Conceptual Processing by L1‐Chinese Learners
International Journal of Applied Linguistics, EarlyView.ABSTRACT Orthographic and phonological similarities between first (L1) and second (L2) languages can facilitate L2 processing. Particularly, L1‐Chinese learners of L2‐Japanese can benefit from the shared morphosyllabic Chinese characters (Japanese kanji/Chinese hanzi) because of their similar orthographies.
Xuehan Zhao, Kexin Xiong, Sachiko Kiyama
wiley +1 more source
Potential Diagnosis and Prognosis Value of Plasma MicroRNA-19a in Esophageal Cancer [PDF]
, 2015 背景：食管癌是发生于食管上皮组织的恶性肿瘤，具有高死亡率、高复发率和高转移率的特点。然而目前针对食管癌敏感的肿瘤标志物不多，且诊断效率较低，远远不能满足临床需求。MicroRNA是一类非编码RNA，可以稳定存在于人体血浆中并且易于检测。据报道，microRNA在诸多疾病状态下会出现表达异常，如食管癌、结直肠癌、肝癌等，这一发现极大地增加了血浆microRNA作为食管癌标志物的可能。在前期实验中，我们观察到microRNA-19a（miR-19a）在食管癌血浆标本中高表达，本文将重点探讨miR ...
白永颖
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International Journal of Applied Linguistics, EarlyView.ABSTRACT Although the use of AI technologies (e.g., chatbots and automated writing evaluations (AWE)) has gained considerable attention in language learning fields in recent years, how AI technologies have been designed and implemented in language learning education, as well as their effectiveness, is understudied.
Shen Qiao +2 more
wiley +1 more source
The study for schizophrenia patients of multi-disciplinary team in community rehabilitation services—take assertive community treatment in S.N, as an example [PDF]
, 2016 精神卫生既是公共卫生问题，也是重大的社会问题。中国内地共有严重精神障碍患者1600万人，精神分裂症患者780万人，其中90%的精神分裂症患者生活在社区，我国精神卫生服务模式正从单纯的医学模式向生理—心理—社会综合模式转变，建立多学科服务团队回应患者及家属的多元需求正在被越来越多的人推崇和认可。主动式社区治疗模式是一种应用于精神分裂症患者的社区照顾模式，该模式通过组建包括社工、精神卫生科医生、心理咨询师和护士等在内的多学科团队，帮助精神障碍患者逐渐恢复独立生活的能力，降低患者住院率，促进患者融入社区和社会。
赵艳军
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Genomic responses to increased temperature and pollinator selection in Brassica rapa L.
New Phytologist, EarlyView.Summary Rapid environmental change reshapes both abiotic stress and biotic interactions, yet it remains unclear how these combined forces structure plants' genomic adaptation. In particular, the joint influence of temperature and pollinator identity, two ecological axes undergoing simultaneous global shifts, has rarely been quantified at genomic ...
Yanqian Ding, Florian P. Schiestl
wiley +1 more source
The Analysis of Erlotinib on Brain Metastases in Patients with Non-small-cell Lung Cancer [PDF]
, 2009 Background and objective Brain metastases are common in non-small-cell lung cancer (NSCLC) and the prognosis is poor. Erlotinib is a specific inhibitor of the epidermal growth factor receptor-associated tyrosine kinase (EGFRTKI), which has been gradually
Baohui HAN, Hao BAI
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