Further considerations to improve the druggability of biaryl hydroxy-triazole and fluorene-triazole hybrids [PDF]
Exploration of Drug ScienceBuarque et al. (Explor Drug Sci. 2025;3:1008107. DOI: 10.37349/eds.2025.1008107) reported the synthesis of 13 biaryl hydroxy-1,2,3-triazoles and 11 fluorene-1,2,3-triazole hybrids via optimized Suzuki and telescopic one-pot reactions.
Zhiqi Liu, Meihong Zhang, Zhengwei Huang
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Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces [PDF]
, 2014 Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them ...
Albuquerque, Hélio +3 more
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Derivatives of grindelic acid: from a non-active natural diterpene to synthetic antitumor derivatives [PDF]
, 2013 Using several reactions that include homologations and asymmetric epoxidations as well as Ugi and Huisgen couplings, we generated a small focused library of new derivatives from the labdane-type diterpene grindelic acid. These compounds were evaluated as
Chiaramello, Alejandra Ilda +7 more
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Síntesis de hidrotalcitas calcinadas Cu/Al y su evaluación catalítica en la obtención de Triazol- Dihidropirimidinonas (T-DHPM) [PDF]
, 2017 85 páginas. Maestría en Ciencias e Ingeniería de Materiales.Se sintetizaron materiales tipo hidrotalcita de cobre y aluminio con relaciones molares Cu:Al 1:1 y 3:1, las hidrotalcitas fueron sometidas a tratamiento térmico para obtener la hidrotalcita ...
LOPEZ ALVAREZ, ITZEL GUADALUPE
core
Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules [PDF]
, 2012 Acknowledgements We thank the European Commission for financial support (Industry Academia Partnerships and Pathways project “PET BRAIN”, Contract No 251482). S.A.
Altomonte, Stefano, Zanda, Matteo
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Synthèse, dérivation et évaluation de pharmacophores hybrides Alcynyl-TriAzolyCarbinols N-glycosylés [PDF]
, 2014 La fonction alcényl-alcynylcarbinol (AAC) est un pharmacophore clé rencontré dans des produits naturels extraits d'éponges marines, les pétrosiacétylènes, aux propriétés biologiques multiples, en particulier une cytotoxicité remarquable sur les cellules ...
Oukessou, Mohamed
core
Insulin-like Growth Factor 1 Analogs Clicked in the C Domain : Chemical Synthesis and Biological Activities [PDF]
, 2017 Human insulin-like growth factor 1 (IGF-1) is a 70 amino acid protein hormone, with key impact on growth, development, and lifespan. The physiological and clinical importance of IGF-1 prompted challenging chemical and biological trials toward the ...
Andrzej M. Brzozowski +11 more
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, 2015 International audienceDFT calculations at the PBE0/LANL2DZ level have been performed on model compounds to investigate the reaction mechanism of two recently reported metal-catalyzed alkyne azide cycloaddition (MAAC).
Astruc, Didier +5 more
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Acta Pharmaceutica, 2017 The present study describes an efficient and ecofriendly, ultrasound, one-pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3-triazoles tethered with fluorinated 1,2,4-triazole-benzothiazole molecular ...
Rezki Nadjet, Aouad Mohamed Reda
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NH-1,2,3-triazoles as versatile building blocks in denitrogenative transformations. [PDF]
RSC Adv, 2023 Motornov V, Beier P.
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