Results 121 to 130 of about 43,142 (242)
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann +10 more
wiley +1 more source
, 2018 A novel relay Rh (II)/cobaloxime (III) dual catalysis strategy has been developed for the stereoselective synthesis of indolyl spiroindanones from readily accessible N-sulfonyl-1,2,3-triazoles.
Hongbin Zhai (1457509) +7 more
core +1 more source
Advanced Materials, Volume 38, Issue 57, 13 October 2026.The transition from cryogenic distillation to polymeric sorbents for light hydrocarbon purification is crucial for energy and environmental sustainability. The polymeric sorbents are engineered to separate gas mixtures based on their specific properties.
Kelechi Festus +9 more
wiley +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, Volume 13, Issue 56, 9 October 2026.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source
Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma
Advanced Science, Volume 13, Issue 58, 19 October 2026.Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul +4 more
wiley +1 more source
, 2016 A series of 1,4-disubstituted 1,2,3-triazoles having thioether as well as amide linkage were synthesized from aryl(prop-2-yn-1-yl)sulfanes and 2-azido-N-substituted acetamides through Cu(I) catalyzed click reaction.
C. P. Kaushik (748698) +3 more
core +1 more source
Design and Synthesis of Novel Biginelli Adducts: Anticancer Activity and In Silico Study
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Compound 8n emerged as the most potent agent against MCF‐7 cells, inducing apoptosis and cell cycle arrest. Molecular docking identified Eg5 kinesin as a potential target, highlighting these derivatives as promising leads for cancer therapeutics.
Aida Iraji +6 more
wiley +1 more source
“Click” Synthesis of Nonsymmetrical Bis(1,2,3-triazoles)
, 2016 Unsymmetrically 1,1′-disubstituted 4,4′-bis-1H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a “double-click” strategy, two complementary approaches were implemented for the preparation of the key 4 ...
Itxaso Azcune (2086078) +5 more
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.New 1,2,3‐disubstituted derivatives were synthesized from N,N‐dimethyltryptamine isolated from Mimosa tenuiflora and evaluated in vitro against chloroquine‐resistant P. falciparum W2. Compound 4 shows the best activity (IC50 = 4.8 ± µM) and selectivity index (> 10), while compound 7 shows the best binding energy (−9.8 kcal/mol) against PfPK7.
Renato Pinto de Sousa +13 more
wiley +1 more source
Utilization of N-fluoroalkyl-1,2,3-triazoles in organic synthesis
, 2021 Athanasios Markos Abstract This Thesis deals with denitrogenative transformations of N-fluoroalkyl-1,2,3-triazoles, easily available heterocycles via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) of safe and stable N-fluoroalkyl azides and ...
Markos, Athanasios
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