Results 1 to 10 of about 12,849 (199)

Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized via Click Chemistry

Molecules, 2012
There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several ...
Wei Gong, Tim Efthymiou, Jean-Paul Desaulniers   +2 more
doaj   +1 more source

Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology

Molecules, 2013
The alkyne-azide cycloaddition, popularly known as the “click” reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of ...
Pramod K. Avti, Dusica Maysinger, Ashok Kakkar   +2 more
doaj   +1 more source

Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

eLife, 2019
The functional mechanisms of membrane proteins are extensively investigated with cysteine mutagenesis. To complement cysteine-based approaches, we engineered a membrane protein with thiol-independent crosslinkable groups using azidohomoalanine (AHA), a ...
Kanchan Gupta, Gilman ES Toombes, Kenton J Swartz   +2 more
doaj   +1 more source

Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment

EngMedicine
With their high drug-loading capacity and enhanced permeability and retention (EPR) effects, nanoparticles possess significant potential for the diagnosis and treatment of tumors.
Yun Yin, Xiaoyang Liu, Xuemei Li, Gaolin Liang   +3 more
doaj   +1 more source

Quarternization of 3-azido-1-propyne oligomers obtained by copper(I)-catalyzed azide–alkyne cycloaddition polymerization

Beilstein Journal of Organic Chemistry, 2015
3-Azido-1-propyne oligomer (oligoAP) samples, prepared by copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) polymerization, were quarternized quantitatively with methyl iodide in sulfolane at 60 °C to obtain soluble oligomers.
Shun Nakano, Akihito Hashidzume, Takahiro Sato   +2 more
doaj   +1 more source

Modification of a single-molecule AFM probe with highly defined surface functionality

Beilstein Journal of Nanotechnology, 2014
Single-molecule force spectroscopy with an atomic force microscope has been widely used to study inter- and intramolecular interactions. To obtain data consistent with single molecular events, a well-defined method is critical to limit the number of ...
Fei Long, Bin Cao, Ashok Khanal, Shiyue Fang, Reza Shahbazian-Yassar   +4 more
doaj   +1 more source

Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides

Communications Chemistry
Bicyclic peptides exhibit improved metabolic stabilities and target specificities when compared to their linear or mono-cyclic counterparts; however, efficient and straightforward synthesis remains challenging due to their intricate architectures.
Masakazu Kobayashi, Naho Onozawa, Kenichi Matsuda, Toshiyuki Wakimoto   +3 more
doaj   +1 more source

An eco-compatible strategy for the diversity-oriented synthesis of macrocycles exploiting carbohydrate-derived building blocks

Beilstein Journal of Organic Chemistry, 2017
An efficient, eco-compatible diversity-oriented synthesis (DOS) approach for the generation of library of sugar embedded macrocyclic compounds with various ring size containing 1,2,3-triazole has been developed.
Sushil K. Maurya, Rohit Rana
doaj   +1 more source

Hierarchical single-crystal-to-single-crystal transformations of a monomer to a 1D-polymer and then to a 2D-polymer

Nature Communications
Designing and synthesizing flawless two-dimensional polymers (2D-Ps) via meticulous molecular preorganization presents an intriguing yet challenging frontier in research.
Haripriya Balan, Kana M. Sureshan
doaj   +1 more source

Copper-Catalyzed Azide-Alkyne Cycloaddition-Oriented Multifunctional Bio-Orthogonal Linker BPPA: Design, Synthesis and Evaluation. [PDF]

Molecules, 2023
Wang S, He X, Li J, Shi E.
europepmc   +1 more source