Results 1 to 10 of about 97,080 (283)
Assembly drives regioselective azide-alkyne cycloaddition reaction. [PDF]
Nat Commun, 2023 Azide-alkyne cycloaddition reaction is a very common organic reaction to synthesize nitrogen-containing heterocycles. Once catalyzed by Cu(I) or Ru(II), it turns out to be a click reaction and thus is widely applied in chemical biology for labeling ...
Jiang Q +6 more
europepmc +3 more sources
Kinetic Resolution of Cyclic Secondary Azides, Using an Enantioselective Copper-Catalyzed Azide-Alkyne Cycloaddition. [PDF]
Org Lett, 2019 An enantioselective copper-catalyzed azide− alkyne cycloaddition (E-CuAAC) is reported by kinetic resolution. Chiral triazoles were isolated in high yield with limiting alkyne (up to 97:3 enantiomeric ratio (er)).
Alexander JR +3 more
europepmc +4 more sources
Recent Advances in Copper-Based Solid Heterogeneous Catalysts for Azide-Alkyne Cycloaddition Reactions. [PDF]
Int J Mol Sci, 2022 The copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC) reaction is considered to be the most representative ligation process within the context of the “click chemistry” concept.
Aflak N +5 more
europepmc +2 more sources
Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) by Functionalized NHC-Based Polynuclear Catalysts: Scope and Mechanistic Insights. [PDF]
Organometallics, 2022 Copper(I) [Cu2(μ-Br)2(tBuImCH2pyCH2L)]n (L = OMe, NEt2, NHtBu) compounds supported by flexible functionalized NHC-based polydentate ligands have been prepared in a one-pot procedure by reacting the corresponding imidazolium salt with an excess of copper ...
González-Lainez M +6 more
europepmc +2 more sources
Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide-alkyne cycloaddition. [PDF]
Beilstein J Org Chem, 2021 A novel catalyst-free synthetic approach to 1,2,3-triazolobenzodiazepinones has been developed and optimized. The Ugi reaction of 2-azidobenzaldehyde, various amines, isocyanides, and acids followed by microwave-assisted intramolecular azide–alkyne ...
Mazur MO +8 more
europepmc +2 more sources
Molecules, 2020 This mini-review presents a general overview of the progress achieved during the last decade on the amalgamation of CuAAC processes (copper-catalyzed azide-alkyne cycloaddition) with the employment of sustainable solvents as reaction media.
N. Nebra, Joaquín García‐Álvarez
semanticscholar +1 more source
Chemical Society Reviews, 2010 Copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a widely utilized, reliable, and straightforward way for making covalent connections between building blocks containing various functional groups.
J. Hein, V. Fokin
semanticscholar +1 more source
Bioconjugate chemistry, 2017 Interrogating biological systems is often limited by access to biological probes. The emergence of “click chemistry” has revolutionized bioconjugate chemistry by providing facile reaction conditions amenable to both biologic molecules and small molecule ...
Chad J. Pickens +4 more
semanticscholar +1 more source
Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications.
Chemical Reviews, 2016 The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer.
Johan R Johansson +3 more
semanticscholar +1 more source
RSC Advances, 2018 Functionalized reverse phase silica gel and thermoresponsive hydrogels were synthesized as heterogeneous catalysts supports. Cu(i) and Cu(ii) catalysts immobilized onto two types of supports were prepared and characterized.
M. Lim +4 more
semanticscholar +1 more source