Results 11 to 20 of about 12,849 (199)

Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach [PDF]

Molecules, 2022
The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)—intramolecular azide-alkyne cycloaddition (IAAC) approach.
Rahul P, Joice Thomas, Wim Dehaen, Jubi John   +3 more
doaj   +2 more sources

Assembly drives regioselective azide-alkyne cycloaddition reaction [PDF]

Nature Communications, 2023
Azide-alkyne cycloaddition reaction is a very common organic reaction to synthesize nitrogen-containing heterocycles. Once catalyzed by Cu(I) or Ru(II), it turns out to be a click reaction and thus is widely applied in chemical biology for labeling ...
Qiaochu Jiang, Wenjun Zhan, Xiaoyang Liu, Lin Bai, Manli Wang, Ying Xu, Gaolin Liang   +6 more
doaj   +2 more sources

Synthesis of Bioconjugation Reagents for Use in Covalent Cross-Linking of Proteins by Azide-Alkyne Cycloaddition [PDF]

Molecules
A series of azide- and cyclooctyne-functionalized N-hydroxysuccinimidyl esters (NHS esters) and benzotriazolides were prepared and used as N-acylation reagents to obtain azide-(BSA-1) and cyclooctyne-functionalized bovine serum albumin proteins (BSA-2 ...
Nadja Suhorepec, Luka Ciber, Uroš Grošelj, Nejc Petek, Bogdan Štefane, Marko Novinec, Jurij Svete   +6 more
doaj   +2 more sources

Copper-catalysed azide–alkyne cycloaddition on live M13 bacteriophage for expanding the molecular diversity of phage-displayed peptide libraries [PDF]

RSC Chemical Biology
Phage display is a powerful platform for ligand evolution, but conventional phage display libraries are confined to the twenty canonical amino acids, greatly limiting the chemical space that these libraries can be used to explore.
Olabode Dawodu, Cody A. White, Caitlin Specht, Alejandro Tapia, Jeffery M. Tharp   +4 more
doaj   +2 more sources

The fate of heterogeneous catalysis & click chemistry for 1,2,3-triazoles: Nobel prize in chemistry 2022

Catalysis Communications, 2023
The demand for environmental friendly methodologies had shifted the the approach of scientific community for using easy and green reaction conditions instead of using hazardous and harsh reaction conditions.
Vijay Kumar, Kashmiri Lal, Naveen, Ram Kumar Tittal   +3 more
doaj   +1 more source

Direct Light-up of cAMP Derivatives in Living Cells by Click Reactions

Molecules, 2013
8-Azidoadenosine 3′,5′-cyclic monophosphate (8-azido cAMP) was directly detected in living cells, by applying Cu-free azide-alkyne cycloaddition to probe cAMP derivatives by fluorescence light-up.
Yan Xu, Hongshan Liu, Tetsuya Hayashi, Makoto Komiyama, Kenichiro Ito   +4 more
doaj   +1 more source

Deposition of Ni(II)Porphyrin Monolayer on the Gold Electrode via Azide-Alkyne Click - Coupling and its Electrochemical Characterization

International Journal of Electrochemical Science, 2014
In this work, a Ni(II)porphyrin containing two azide groups ((N3)2-Ni(II)porphyrin) was applied for gold electrode modification via azide-alkyne click reaction.
Iwona Grabowska, Magdalena Zborowska, Nguyen Tran Nguyen, Wim Dehaen, Eugen Stulz, James W. Wood, Hanna Radecka, Jerzy Radecki   +7 more
doaj   +1 more source

Copper-catalyzed Z-selective synthesis of acrylamides and polyacrylamides via alkylidene ketenimines

Nature Communications, 2022
Alkylidene ketenimines are rarely reported, but synthetically useful, reactive intermediates. Here, the authors disclose a three-component reaction of alkyne, azide and water by cycloaddition, nitrogen extrusion, and carbene-assisted rearrangement, via ...
Xuelun Duan, Nan Zheng, Ming Li, Gongbo Liu, Xinhao Sun, Qiming Wu, Wangze Song   +6 more
doaj   +1 more source

Pullulan-Graft-Polyoxazoline: Approaches from Chemistry and Physics

Molecules, 2023
An approach to the preparation of pullulan-graft-poly(2-methyl-2-oxazoline)s based on Cu-catalyzed azide–alkyne cycloaddition with polyoxazoline-azide was applied.
Ivan M. Zorin, Petr A. Fetin, Nina G. Mikusheva, Alexey A. Lezov, Igor Perevyazko, Alexander S. Gubarev, Anna N. Podsevalnikova, Sergey G. Polushin, Nikolai V. Tsvetkov   +8 more
doaj   +1 more source

Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates

Molecules, 2018
Novel BODIPY–estrone conjugates were synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). Estrone-alkynes or an estrone-azide as starting compounds were synthesized via Michael addition or Sonogashira reaction as key steps ...
Ildikó Bacsa, Csilla Konc, Anna Boglárka Orosz, Gábor Kecskeméti, Réka Rigó, Csilla Özvegy-Laczka, Erzsébet Mernyák   +6 more
doaj   +1 more source