Results 31 to 40 of about 97,080 (283)

Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition

, 2011
A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Krim, Jamal, Taourirte, Mohamed, Engels, Joachim W., Moha Taourirte, Jamal Krim, Joachim W. Engels   +5 more
core   +1 more source

Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation

Biomolecules, 2020
Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized ...
Kelvin K. Tsao, Ann C. Lee, Karl É. Racine, Jeffrey W. Keillor   +3 more
doaj   +1 more source

Incorporation of Spin Labels and Paramagnetic Tags for Magnetic Resonance Studies Using Cycloaddition Reactions as a Tool

Reactions
The cycloaddition reaction is one of the most common reactions in organic chemistry. It has been applied in various fields. Herein, we focus on the application of cycloaddition reactions in investigating biological molecules and materials using magnetic ...
Amarendra Nath Maity, Amiya Kumar Medda, Shyue-Chu Ke   +2 more
doaj   +1 more source

N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide

Molbank, 2021
The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3 ...
Paolo Coghi, Jerome P. L. Ng, Ali Adnan Nasim, Vincent Kam Wai Wong   +3 more
doaj   +1 more source

Synthesis of precursors and studies of "click" azide-alkyne cycloaddition [PDF]

, 2010
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Jana Ivincová Supervisor: PharmDr. Petr Zimčík, Ph.D.
Ivincová, Jana
core   +1 more source

Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles

Beilstein Journal of Organic Chemistry, 2013
A microwave-assisted three-component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide, and an intramolecular Huisgen azide–internal alkyne 1,3-dipolar cycloaddition domino sequence ...
Rajesh K. Arigela, Sudhir K. Sharma, Brijesh Kumar, Bijoy Kundu   +3 more
doaj   +1 more source

Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions

Molecules, 2016
This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
Xiaoguang Zhang, Peiye Liu, Lei Zhu
doaj   +1 more source

Dinuclear Copper(I) Thiodiacetate Complex-Mediated Expeditious Synthesis of the Chlorine-Containing Cyclen-Cored 36-Glucose-Coated Glycodendrimer

Journal of Chemistry, 2021
High-sugar-tethered glycodendrimers are a remarkable tool in glycobiology for the investigation of carbohydrate-protein interaction using its multivalency property.
Anand K. Agrahari, Sunil Kumar, Anindra Sharma, Vinod K. Tiwari   +3 more
doaj   +1 more source

Ruthenium-Catalyzed Azide Alkyne Cycloaddition (RuAAC)

, 2021
Under ruthenium catalysis, 1,5-disubstituted 1,2,3-triazoles can be accessed with high selectivity from terminal alkynes and organic azides via a ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) reaction. In addition, these conditions allow the use
Kann, Nina,, Kann, Nina, Paterson, Andrew, Paterson, Andrew,, Beke-Somfai, Tamas, Beke-Somfai, Tamas,   +5 more
core   +1 more source

Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging

Molecules
Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza, Przemysław W. Szafrański, Joanna Fedorowicz, Faustyna Krzysztofiak, Krzysztof Pociecha, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Mariusz Kępczynski, Jarosław Sączewski, Paweł Zajdel, Marek Cegła   +10 more
doaj   +1 more source