Results 31 to 40 of about 28,418 (220)

Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation

Biomolecules, 2020
Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized ...
Kelvin K. Tsao, Ann C. Lee, Karl É. Racine, Jeffrey W. Keillor   +3 more
doaj   +1 more source

N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]quinoline]-acetamide

Molbank, 2021
The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3 ...
Paolo Coghi, Jerome P. L. Ng, Ali Adnan Nasim, Vincent Kam Wai Wong   +3 more
doaj   +1 more source

Incorporation of Spin Labels and Paramagnetic Tags for Magnetic Resonance Studies Using Cycloaddition Reactions as a Tool

Reactions
The cycloaddition reaction is one of the most common reactions in organic chemistry. It has been applied in various fields. Herein, we focus on the application of cycloaddition reactions in investigating biological molecules and materials using magnetic ...
Amarendra Nath Maity, Amiya Kumar Medda, Shyue-Chu Ke   +2 more
doaj   +1 more source

Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions

Molecules, 2016
This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
Xiaoguang Zhang, Peiye Liu, Lei Zhu
doaj   +1 more source

Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles

Beilstein Journal of Organic Chemistry, 2013
A microwave-assisted three-component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide, and an intramolecular Huisgen azide–internal alkyne 1,3-dipolar cycloaddition domino sequence ...
Rajesh K. Arigela, Sudhir K. Sharma, Brijesh Kumar, Bijoy Kundu   +3 more
doaj   +1 more source

Covalent Attachment of Aggregation-Induced Emission Molecules to the Surface of Ultrasmall Gold Nanoparticles to Enhance Cell Penetration

Molecules, 2022
Three different alkyne-terminated aggregation-induced emission molecules based on a para-substituted di-thioether were attached to the surface of ultrasmall gold nanoparticles (2 nm) by copper-catalyzed azide–alkyne cycloaddition (click chemistry).
Kai Klein, Matthias Hayduk, Sebastian Kollenda, Marco Schmiedtchen, Jens Voskuhl, Matthias Epple   +5 more
doaj   +1 more source

Click Chemistry in Materials Science [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106803/1/adfm201302847 ...
Bowman, Christopher N., Kloxin, Christopher J., Scott, Timothy F., Xi, Weixian   +3 more
core   +1 more source

Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging

Molecules
Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy.
Patryk Kasza, Przemysław W. Szafrański, Joanna Fedorowicz, Faustyna Krzysztofiak, Krzysztof Pociecha, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Mariusz Kępczynski, Jarosław Sączewski, Paweł Zajdel, Marek Cegła   +10 more
doaj   +1 more source

Azetidinylideneketenimines as a Multimodal Synthetic Platform: Coordination Chemistry and Cycloaddition‐Triggered Transformations

Angewandte Chemie, EarlyView.
Cross‐coupling/homologation sequence between a stable three‐membered‐ring carbene and isocyanides enables facile and rapid access to novel methyleneketenimines and the first bis(methyleneketenimine). Reactivity studies gave rise to the first methyleneketenimine‐transition metal complexes, unique multimodal reactivity ranging from CO2, isocyanate ...
Taichi Koike, Keisuke Ito, Shintaro Ishida, Takeaki Iwamoto   +3 more
wiley   +2 more sources

Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey [PDF]

, 2009
With the goal of identifying alkyne-like reagents for use in click chemistry, but without Cu catalysts, we used B3LYP density function theory (DFT) to investigate the trends in activation barriers for the 1,3-dipolar cycloadditions of azides with various
Chenoweth, David, Chenoweth, Kimberly, Goddard, William A. III   +2 more
core   +1 more source