Results 111 to 120 of about 43,142 (242)

Azide–alkyne cycloaddition (click) reaction in biomass-derived solvent CyreneTM under one-pot conditions

Beilstein Journal of Organic Chemistry
It was demonstrated that CyreneTM, as a biomass-originated polar aprotic solvent, could be utilized as an alternative reaction medium for one-pot copper(I)-catalyzed azide–alkyne cycloaddition (click or CuAAC) reactions, for the synthesis of various 1,2 ...
Zoltán Medgyesi, László T. Mika
doaj   +1 more source

Combined XRD-paramagnetic 13C NMR spectroscopy of 1,2,3-triazoles for revealing copper traces in a Huisgen click-chemistry cycloaddition. A model case

Heterocyclic Communications, 2019
Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) click chemistry robustness has been demonstrated over recent years to produce 1,2,3-triazoles with excellent yields at mild conditions with simple purification methods.
Canseco-González Daniel, O José Luis Rodríguez de la, Herbert-Pucheta José Enrique   +2 more
doaj   +1 more source

A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações

Química Nova, 2011
The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily ...
Luiza Baptista de Oliveira Freitas, Fernando Armini Ruela, Guilherme Rocha Pereira, Rosemeire Brondi Alves, Rossimiriam Pereira de Freitas, Leandro José dos Santos   +5 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor, João de Sousa‐Lourenço, Ivana Nikić‐Spiegel   +2 more
wiley   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Limiting Trial‐and‐Error: Linker‐Based 2D Descriptor Analysis to Support Very Early Proteolysis‐Targeting Chimeras Design

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Can simple linker descriptors guide PROTAC design? Analysis of matched CRBN‐ and VHL‐recruiting degraders shows that basic 2D linker properties may capture trends linked to degradation efficiency, in vitro ADME and physicochemical properties. A practical approach to reduce trial‐and‐error in early targeted protein degradation programs. Targeted protein
Giulia Apprato, Serena Traversa, Giulia Caron, Giuseppe Ermondi   +3 more
wiley   +1 more source

13.13.6 1,2,3-Triazoles (Update 2015)

, 2016
This chapter is an update to the earlier Science of Synthesis contribution (Section 13.13) describing methods for the synthesis of 1,2,3-triazoles. Recent interest in this area has mainly been generated by the discovery that copper(I)-catalyzed azide ...
A. C. Tomé
core   +1 more source

Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou, Jinbiao Jiao, Mathieu Lordez, Jean‐Yves Salpin, Juan Xie   +4 more
wiley   +1 more source

Synthesis of 6-Amino-5-cyano-1,4-disubstituted-2(1H)-Pyrimidinones via Copper-(I)-catalyzed Alkyne-azide ‘Click Chemistry’ and Their Reactivity

Molecules, 2010
In this paper we present the room temperature synthesis of a novel serie of 1,4-disubstituted-1,2,3-triazoles 4a-l by employing the (3 + 2) cycloaddition reaction of pyrimidinones containing alkyne functions with different model azides in the presence of
Fethi Zribi, Romain Duval, Fakher Chabchoub, Françoise Nepveu, Ennaji Najahi, Jan Sudor   +5 more
doaj   +1 more source