Results 1 to 10 of about 41,138 (191)

Synthesis of Substituted 1,2,4-Triazole-3-Thione Nucleosides Using E. coli Purine Nucleoside Phosphorylase [PDF]

Biomolecules
1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole
Ilya V. Fateev, Sobirdjan A. Sasmakov, Jaloliddin M. Abdurakhmanov, Abdukhakim A. Ziyaev, Shukhrat Sh. Khasanov, Farkhod B. Eshboev, Oybek N. Ashirov, Valeriya D. Frolova, Barbara Z. Eletskaya, Olga S. Smirnova, Maria Ya. Berzina, Alexandra O. Arnautova, Yulia A. Abramchik, Maria A. Kostromina, Alexey L. Kayushin, Konstantin V. Antonov, Alexander S. Paramonov, Valeria L. Andronova, Georgiy A. Galegov, Roman S. Esipov, Shakhnoz S. Azimova, Anatoly I. Miroshnikov, Irina D. Konstantinova   +22 more
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1,2,4-Triazoles as Important Antibacterial Agents [PDF]

Pharmaceuticals, 2021
The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity. A large volume of research on triazole and their derivatives has been carried out, proving significant antibacterial activity of ...
Małgorzata Strzelecka, Piotr Świątek
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Modern approaches to studying the antimicrobial and antifungal activities of new 1,2,4-triazole derivatives

Фармацевтичний журнал, 2022
1,2,4-Triazole and its derivatives are a promising class of organic compounds. For a long time, they remain in the spotlight due to a number of unique properties: high ability to chemical transformations, the presence of various types of biological ...
M. V. Ogloblina, I. V. Bushueva, V. V. Parchenko   +2 more
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Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative

Journal of International Medical Research, 2020
Objectives The purpose of this paper was to synthesize 4-amino-1,2,4-triazole Schiff base derivative and to evaluate its antitumor activity. Methods 2,4,6-Tris (4-formylphenoxy)-1,3,5-triazine was synthesized by nucleophilic substitution with reaction of
Guo-wei Jiang, Qing Chang, Dong-yu Liang, Yu-ting Zhang, Yong-jun Meng, Qing-qing Yi   +5 more
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Review of the research on the influence of different functional substituents of new 1,2,4-triazole derivatives on the compounds biological properties

Фармацевтичний журнал, 2022
Today, 1,2,4-triazole derivatives are a promising class of organic compounds. This is caused, first of all, by the possibility of various chemical modifications of the 1,2,4-triazole fragment due to the addition of typical pharmacophores, which ...
M. V. Ogloblina, I. V. Bushueva, V. V. Parchenko   +2 more
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Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The resistance of such strains as Staphylococcus aureus, Escherichia coli extends to many antimicrobial drugs. This problem can be solved by searching for new drugs with high bactericidal and antifungal action.
Ye. O. Karpun, N. M. Polishchuk
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Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]

, 2015
We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth, Aleksandra Strzelczyk, Anna Malm, Barbara Kaproń, Barbara Rajtar, Dalhoff, Małgorzata Polz-Dacewicz, Oliphant, Paweł Stączek, Sharma, Tomasz Plech, Urszula Kosikowska, Łukasz Świątek   +12 more
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1,2,4-Triazoles. VII. Methylation of 1,2,4-triazoles.

Chemical and Pharmaceutical Bulletin, 1976
The methylations of twenty-five 1, 2, 4-triazoles with methyl iodide and diazomethane were studied and substituent effects on the product ratios are discussed. Methylation of 1, 2, 4-triazole and its symmetrically 3, 5-disubstituted derivatives occurred almost exclusively at the 1-position.
MASAYUKI UDA, YUKINORI HISAZUMI, KOJI SATO, SEIJU KUBOTA   +3 more
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Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The aim of study was to investigate diuretic activity of 1,2,4-triazole derivatives which contain С5 atom 5-bromfuran-2-yl substituent in the 1,2,4-triazole nucleus, and to establish interrelation between chemical structure and diuretic action of 1,2,4 ...
Ye. S. Pruglo, A. S. Gotsulya, O. I. Panasenko, Ye. G. Knysh   +3 more
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Potential energetic salts of 5,5′-methylenedi(4H-1,2,4-triazole-3,4-diamine) cation: Synthesis, characterization and detonation performance

Energetic Materials Frontiers, 2022
1,2,3-Triazole and 1,2,4-triazole have been vigorously used in energetic materials research. Among these two, 1,2,4-triazole has been a widely used backbone in designing new energetic materials with improved performance.
Ramling S Mathpati, Abhishek Kumar Yadav, Vikas D Ghule, Srinivas Dharavath   +3 more
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