Results 71 to 80 of about 300,590 (210)

Effects of Vitamin D and Dexamethasone on Lymphocyte Proportions and Their Associations With Serum Concentrations of 25-Hydroxyvitamin D3In Vitro in Patients With Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
BackgroundClear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate.Objective and ...
Eun Bin Cho, Eun Bin Cho, Jong Hwa Shin, Jong Hwa Shin, Soonwook Kwon, Juhyeon Kim, Juhyeon Kim, Jin Myoung Seok, Byoung Joon Kim, Byoung Joon Kim, Ju-Hong Min, Ju-Hong Min, Ju-Hong Min   +12 more
doaj   +1 more source

Exploring Vitamin D Metabolism in Gynaecological Malignancies: Redox‐Dependent and Redox‐Independent Anticancer Mechanisms From Preclinical Models to Clinical Evidence

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Gynaecological malignancies account for over 1.4 million new diagnoses, with outcomes constrained by late‐stage presentation and chemoresistance. Dysregulated redox homeostasis is a hallmark of tumourigenesis. Tumour cells maintain elevated basal reactive oxygen species (ROS), which support proliferative signalling but may also increase ...
Hoi Ching Cherry Chan, Sachin Bhoora, Esther Zhou, Sumari Marais, Rivak Punchoo   +4 more
wiley   +1 more source

Enterohepatic physiology of 1,25-dihydroxyvitamin D3. [PDF]

Journal of Clinical Investigation, 1980
After intravenous administration of radiolabeled 1,25-dihydroxyvitamin D3 to rats, approximately 25% of the administered radioactivity appeared in the bile within 24 h. Instillation of the biliary radioactivity into the duodena of other rats was followed by recovery of 15% of the radioactivity in newly secreted bile within 24 h.
R, Kumar, S, Nagubandi, V R, Mattox, J M, Londowski   +3 more
openaire   +2 more sources

Neuropathic Pain Comorbid Cognitive Impairment and Vitamin D: A Narrative Review From Mechanisms to Clinical Management

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Vitamin D is an essential fat‐soluble nutrient primarily obtained through cutaneous synthesis triggered by ultraviolet exposure and dietary intake. After systemic metabolism and activation, it binds to vitamin D receptors widely distributed in the central and peripheral nervous systems, exerting pleiotropic neuroprotective and regulatory biological ...
Nan Zhao, Yang Yang, Wanqiu Yu, Yuhang Zhu, Zhaoqiong Zhu   +4 more
wiley   +1 more source

1,25-Dihydroxyvitamin D3 Attenuates Angiotensin II-Induced Renal Injury by Inhibiting Mitochondrial Dysfunction and Autophagy

Cellular Physiology and Biochemistry, 2018
Background/Aims: A recent study has shown that 1,25-dihydroxyvitamin D3 (1,25-D3), the active form of vitamin D, can ameliorate renal dysfunction. In this study, we aimed to determine the role of 1,25-D3 in angiotensin (Ang II)-induced renal injury and ...
Qiqi Shen, Xiao Bi, Lilu Ling, Wei Ding
doaj   +1 more source

Ciliary Ift20 and Wwtr1 Coordinate Transforming Growth Factor‐β Receptor II Signaling to Maintain Bone–Fat Balance in Skeletal Homeostasis

MedComm, Volume 7, Issue 10, October 2026.
Deletion of Ift20 and Wwtr1 in osteoprecursors promoted adipogenic differentiation while suppressing osteogenesis and bone remodeling through dysregulation of TGF‐β signaling. Mechanistically, Ift20 stabilized TβRII by inhibiting c‐Cbl‐mediated ubiquitination and proteasomal degradation. In parallel, Wwtr1 functioned as a transcriptional regulator that
Yang Li, Yang Yang, Shuting Yang, Huijuan Chang, Yi‐Ping Li, Shuying Yang   +5 more
wiley   +1 more source

Synergistic Effect of Honey Bee Venom and 1,25-Dihydroxyvitamin D3 on the Induction of HL-60 Promyelocytic Leukemia Cell Line Differentiation

پزشکی بالینی ابن سینا, 2010
Introduction & Objective: Acute promyelocytic leukemia (APL) is a kind of acute leukemia characterized by a balanced t (15, 17) translocation which fails to develop into mature cells and proliferate in an unregulated fashion.
Homa Mohseni Kouchesfehani, Kazem Parivar, Mohammad Nabiyouni, Maryam Rahimi   +3 more
doaj  

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Maternal Vitamin D Deficiency is Associated With Sex‐Dependent Alterations in Neurodevelopment‐Related Gene Expression, Particularly in the Hypothalamus

Molecular Nutrition &Food Research, Volume 70, Issue 20, 28 October 2026.
Maternal vitamin D deficiency (VDD) affects early brain development in a sex‐dependent manner. VDD accelerates neuronal differentiation and synaptogenesis. Male offspring exhibit broader transcriptomic alterations, including dysregulation of melanocortin‐pathway and synaptic signaling genes, indicating greater vulnerability of hypothalamic circuits ...
Lidia Saidi, Emmanuel Snacel‐Fazy, Eva Seipelt, Nicole Haroun, Julien Astier, Charlène Couturier, Mohamed El Soltani, Eric Sérée, Flavie Sicard, Habib Hammou, Michel Puceat, Jean‐François Landrier, Lourdes Mounien   +12 more
wiley   +1 more source

Role of vitamin D receptor in the regulation of CYP3A gene expression

Acta Pharmaceutica Sinica B, 2019
Vitamin D3 (VD3) is a multifunctional nutrient which can be either synthesized or absorbed from the diet. It plays a pivotal role in systemic calcium and phosphate homeostasis, as well as in various physiological and pathological processes.
Xuan Qin, Xin Wang
doaj   +1 more source